Marina Wagner

Author Correction: FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis

Gina Picchiarelli, Maria Demestre, Amila Zuko, Marije Been et autres

fr, de, nl, us (code pays fourni par la source)

FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis

Gina Picchiarelli, Maria Demestre, Amila Zuko, Marije Been et autres

fr, de, nl, us (code pays fourni par la source)

Modification of the 4-phenylbutyl side chain of potent 3-benzazepine-based GluN2B receptor antagonists

Marina Wagner, Dirk Schepmann, Simon Mensah Ametamey, Bernhard Wünsch

de, ch (code pays fourni par la source)

Xrp1 genetically interacts with the ALS-associated FUS orthologue caz and mediates its toxicity

Moushami Mallik, Marica Catinozzi, Clemens B. Hug, Li Zhang et autres

Cabeza (caz) is the single Drosophila melanogaster orthologue of the human FET proteins FUS, TAF15, and EWSR1, which have been implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. In this study, we identified Xrp1, a nuclear chromatin-binding protein, as a key …

nl, de (code pays fourni par la source)

Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila

Sandra Rode, Henrike Ohm, Lea Anhäuser, Marina Wagner et autres

Dendrite pruning of Drosophila sensory neurons during metamorphosis is induced by the steroid hormone ecdysone through a transcriptional program. In addition, ecdysone activates the eukaryotic initiation factor 4E-binding protein (4E-BP) to inhibit cap-dependent translation initiation. To uncover how efficient translation of ecdysone …

de, us (code pays fourni par la source)

Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis

Jelena Scekic‐Zahirovic, Hajer El Oussini, Sina Mersmann, Kevin Drenner et autres

Motor neuron-extrinsic mechanisms have been shown to participate in the pathogenesis of ALS-SOD1, one familial form of amyotrophic lateral sclerosis (ALS). It remains unclear whether such mechanisms contribute to other familial forms, such as TDP-43 and FUS-associated ALS. Here, we characterize a …

fr, de, us (code pays fourni par la source)

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss

Jelena Scekic‐Zahirovic, Oliver Sendscheid, Hajer El Oussini, Mélanie Jambeau et autres

FUS is an RNA-binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS-containing aggregates are often associated with concomitant loss of nuclear FUS Whether loss of nuclear FUS function, gain of a cytoplasmic function, or a combination of …

fr, de, us, gb (code pays fourni par la source)

Correction: Corrigendum: Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases

Sven Niehues, Julia Bussmann, Georg Steffes, Ines Erdmann et autres

Nature Communications 6: Article number: 7520 (2015); Published: 3 July 2015; Updated: 21 January 2016. The authors inadvertently omitted Sumit Jaiswal, who was originally included in the Acknowledgements section of this Article and contributed to the cloning of transgenic constructs and the …

Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases

Sven Niehues, Julia Bussmann, Georg Steffes, Ines Erdmann et autres

Dominant mutations in five tRNA synthetases cause Charcot-Marie-Tooth (CMT) neuropathy, suggesting that altered aminoacylation function underlies the disease. However, previous studies showed that loss of aminoacylation activity is not required to cause CMT. Here we present a Drosophila model for CMT with …

de, us (code pays fourni par la source)

Highly efficient cell-type-specific gene inactivation reveals a key function for the Drosophila FUS homolog cabeza in neurons

Marie Frickenhaus, Marina Wagner, Moushami Mallik, Marica Catinozzi et autres

To expand the rich genetic toolkit of Drosophila melanogaster, we evaluated whether introducing FRT or LoxP sites in endogenous genes could allow for cell-type-specific gene inactivation in both dividing and postmitotic cells by GAL4-driven expression of FLP or Cre recombinase. For proof …

de (code pays fourni par la source)

IgG2a immune complexes enhance C5a-mediated inflammation

Marina Wagner, Christian Marcel Karsten, Jörg Köhl

us (code pays fourni par la source)

Engel & Maschinen:: Die Kultur der Apolypse

Marina Wagner