Anne Marie McLaughlin

False positive fluoroquinolone resistance in Mycobacterium tuberculosis complex detected by the Cepheid Xpert® MTB/XDR assay

Simone Mok, Emma Roycroft, Anne Marie McLaughlin, Lorraine Dolan et autres

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A call to action on antimicrobial stewardship in tuberculosis: safeguarding effective tuberculosis treatment for future generations

Thomas Theo Brehm, Askar Yedilbayev, Ihor Perehinets, Diane Ashiru-Oredope et autres

On 8 and 9 June 2026, the 1st Conference on Antimicrobial Stewardship in Tuberculosis convened in Chişinău, Republic of Moldova, bringing together more than 60 experts from across the WHO European Region. The conference adopted the following call for action.

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Comorbid diabetes disease severity and microbial changes in patients with bronchiectasis: a combined analysis of data from the EMBARC, EMBARC-India, Australian, and BE-China registries

Rebecca C Hull, Yang Liu, Zu Cao, Kathryna Tan Li Xuan et autres

BACKGROUND: Bronchiectasis and diabetes commonly coexist and are associated with immune dysfunction and increased susceptibility to infection. Although diabetes is associated with worse prognosis in cystic fibrosis-related bronchiectasis, data are scarce for its impact on non-cystic fibrosis bronchiectasis. This study aimed to …

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Monocyte metabolic plasticity and cytokine production differentiate latent TB infection from active disease

Gráinne Jameson, Isabella Batten, Adam H. Dyer, C. Geoghegan et autres

RATIONALE: Monocytes are central to host defence against Mycobacterium tuberculosis (Mtb), yet their functional and metabolic profiles during latent TB infection (TBI) and active TB disease (TBD) remain poorly defined. Immunometabolic dysfunction may underlie ineffective responses in TB, but cell-specific mechanisms are …

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Latent tuberculosis infection screening and treatment outcomes in healthcare workers in Irish hospitals: a multi-centre cohort study

Melva Tan, Zainab Albaggal, Ciara Anderson, Daragh McGee et autres

Abstract Objective: To evaluate factors associated with positive LTBI screening among HCWs and predictors of treatment initiation and completion across hospital sites in Ireland. Design: Multicentre retrospective cohort study. Setting: Five hospital sites in Ireland. Participants: N = 755 healthcare workers (HCWs). …

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First episode of psychosis in a patient undergoing tuberculosis treatment

John M. Murray, Lorraine Dolan, Ciara MacKenna, John Cooney et autres

Shareable abstract Psychosis is a potential side-effect of isoniazid therapy that clinicians involved in the care of patients with tuberculosis should be aware of. https://bit.ly/4n2gXrX

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Characterising systemic inflammation in patients with bronchiectasis: data from the EMBARC BRIDGE study

Chloe Hughes, B Long Merete, Kateryna Viligorska, Jamie Stobo et autres

Introduction: Bronchiectasis is a systemic inflammatory disease with a proposed role for neutrophils in disease pathogenesis. The mechanisms leading to systemic inflammation are not well understood. Methods: Multi-centre, international observational study of patients with stable bronchiectasis (BRIDGE study; NCT03791086 ). Patients were …

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Characterising adult Primary ciliary dyskinesia (PCD) in the EMBARC-BRIDGE cohort

Amelia Shoemark, Holly Lind, Kateryna Viligorska, Pieter Goeminne et autres

PCD is an inherited cause of bronchiectasis. EMBARC-BRIDGE is a translational research substudy embedded within the European Bronchiectasis Registry. We compare patients with PCD in EMBARC BRIDGE to bronchiectasis of other causes. Adults with bronchiectasis were recruited to an observational cohort study …

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Pan-European validation of the Bronchiectasis Health Questionnaire: data from the EMBARC-BRIDGE study

Arietta Spinou, Holly Lind, Pieter Goeminne, Michal Shteinberg et autres

Introduction: The Bronchiectasis Health Questionnaire (BHQ) is a simple, easy to use patient-reported outcome measure in patients with bronchiectasis, with a total score. This study examined the BHQ and its relationship with clinical measures in a multicentre European cohort. Methods: The EMBARC-BRIDGE …

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Profiling peripheral blood neutrophils in patients with bronchiectasis: an EMBARC study

Chloe Hughes, B Long Merete, Morven Shuttleworth, Holly Lind et autres

Introduction: Neutrophilic inflammation is implicated in the pathogenesis of bronchiectasis. Whether peripheral blood neutrophil function is altered in bronchiectasis patients is controversial. Methods: Single-centre observational study of patients with stable bronchiectasis enrolled in Dundee, UK. Peripheral blood was collected from bronchiectasis patients …

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EMBARC-BRIDGE: a representative biorepository to support translational research in bronchiectasis

Morven Shuttleworth, Holly Lind, Pieter Goeminne, Michal Shteinberg et autres

The Bronchiectasis Research Involving Databases, Genomics and Endotyping (BRIDGE) study is a translational research subcohort of the EMBARC registry collecting extensive biosamples. We report characteristics of patients in the BRIDGE study compared to the EMBARC registry. Patients with bronchiectasis on HRCT ≥18yrs …

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A prospective UK study to evaluate the bronchiectasis impact measure in patients with bronchiectasis: data from the EMBARC-BRIDGE study

Holly Lind, Pieter Goeminne, Michal Shteinberg, Anthony De Soyza et autres

Introduction: Various patient-reported outcome (PRO) measures are available for use in bronchiectasis clinical research. The bronchiectasis impact measure (BIM) is a visual analogue scale-based PRO that assesses the impact of multiple individual symptoms. Aim: To determine the relationship of the BIM with …

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