Wenxuan Zhen

Rationally designed peptides relieve ischemic stroke by targeting TRPM2 intramolecular interactions

Jing Yao, Qing You, Xingyu Liu, Wenxuan Zhen et autres

TRPM2 is a calcium-permeable cation channel that functions as an oxidative stress sensor and plays a key role in various pathologies, particularly ischemic stroke. The activation of hsTRPM2 requires cooperative engagement of its N‑ and C‑terminal domains, a mechanism distinct among TRP …

cn (code pays fourni par la source)

Rational tuning of temperature sensitivity of the TRPM8 channel

Lizhen Xu, Xiao Liang, Yunfei Wang, Han Wen et autres

Detecting temperature is crucial for the survival of living organisms. Although the temperature sensitive Transient Receptor Potential Melastatin 8 (TRPM8) channel has been identified as the prototypical cold sensor, the mechanisms by which it detects temperature remain elusive. In this study, we …

cn (code pays fourni par la source)

Discovery and structural basis of endogenous and exogenous inhibitors of the proton-activated-chloride channel

Heng Zhang, Zhijun Zhao, Xiaoying Chen, Qingxia Ma et autres

The proton-activated chloride (PAC) channel is a broadly expressed chloride channel that senses extracellular acidification, regulates endosomal acidification, and participates in many processes, including acid-induced cell death and cancer cell migration. However, the lack of specific modulators has limited our understanding of …

cn (code pays fourni par la source)

Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger

Yangzhuoqun Wan, Shuangshuang Guo, Wenxuan Zhen, Lizhen Xu et autres

The ClC-3 chloride/proton exchanger is both physiologically and pathologically critical, as it is potentiated by ATP to detect metabolic energy level and point mutations in ClC-3 lead to severe neurodegenerative diseases in human. However, why this exchanger is differentially modulated by ATP, …

cn (code pays fourni par la source)

Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel

Wenxuan Zhen, Zhijun Zhao, Shenghai Chang, Xiaoying Chen et autres

The transient receptor potential vanilloid 4 (TRPV4) channel is a polymodal receptor that is activated by warm temperature, osmolarity changes, and many ligands 1 . Like other members in the TRPV family, TRPV4 is critically involved in a plethora of physiological processes …

cn (code pays fourni par la source)

Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption

Mobai Li, Dehang Yang, Huige Yan, Zhibin Tang et autres

cn (code pays fourni par la source)

Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands

Nannan Su, Wenxuan Zhen, Heng Zhang, Lingyi Xu et autres

cn (code pays fourni par la source)

A common mechanism of temperature-sensing in thermoTRP channels

Lizhen Xu, Xiao Liang, Wenxuan Zhen, Zhangzhi Xue et autres

SUMMARY Detecting temperature is crucial for the survival of living organisms. Though the thermo transient receptor potential (thermoTRP) channels, such as TRPV1 or TRPM8, have been identified as prototypic heat or cold sensors, respectively, how they detect temperature remains elusive. Here we …

cn (code pays fourni par la source)

Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel

Xiafei Yu, Yuan Xie, Xiaokang Zhang, Cheng Ma et autres

, warm temperature, and oxidative stress. It is critically involved in physiological and pathological processes ranging from inflammation to stroke to neurodegeneration. At present, the channel's gating and ion permeation mechanisms, such as the location and identity of the selectivity filter, remain …

cn, gb (code pays fourni par la source)

Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2

Ying Huang, Shanhe Yu, Wenxuan Zhen, Tao Cheng et autres

as two potential therapeutic targets for myeloid malignant diseases.

cn, us (code pays fourni par la source)

Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation

Zhexu Chi, Sheng Chen, Ting Xu, Wenxuan Zhen et autres

cn (code pays fourni par la source)