Lizhen Xu

TRPC4/TRPC5 are critical for neuronal modulation by transcranial focused ultrasound in retrosplenial cortex in male mice

Cheng Wu, Jie You, Tao Sheng, Guo-Feng Li et autres

Transcranial focused ultrasound (tFUS) enables non-invasive neuromodulation, yet its underlying molecular mechanisms remain largely elusive. Here, we show that transient receptor potential canonical 4 (TRPC4) and transient receptor potential canonical 5 (TRPC5) channels are critical mediators of tFUS-induced neuronal modulation in the …

cn, us (code pays fourni par la source)

Redundant Queries in DETR-Based 3D Detection Methods: Unnecessary and Prunable

Lizhen Xu, Zehao Wu, W. QIU, Shanmin Pang et autres

Query-based models are extensively used in 3D object detection tasks, with a wide range of pre-trained checkpoints readily available online. However, despite their popularity, these models often require an excessive number of object queries, far surpassing the actual number of objects to …

cn (code pays fourni par la source)

BPS2026 – Rational tuning of temperature sensitivity in the TRPM8 channel

Lizhen Xu, Xiao Liang, Yunfei Wang, Han Wen et autres

cn, us (code pays fourni par la source)

Abstract DP007: Individual Participant Data Meta-Analysis of Randomized Trials of Direct Oral Anticoagulants compared with Aspirin in Patients with Embolic Strokes of Undetermined Source

Aristeidis H. Katsanos, Mukul Sharma, Hans Christoph Diener, Hooman Kamel et autres

Background: Anticoagulation did not reduce the risk of stroke recurrence compared with antiplatelet therapy in randomized controlled trial (RCT) participants with embolic stroke of undetermined source (ESUS). Subsequent analyses of individual RCTs suggested a benefit of anticoagulation in particular subgroups, but these …

ca, de, us, au, jp (code pays fourni par la source)

Abstract DP282: CTA Spot Sign and Response to Andexanet in FXai-associated Intracerebral Hemorrhage: a Secondary Analysis of ANNEXa-I

Mohamed M. Alshamrani, Umberto Pensato, Koji Tanaka, Aristeidis H. Katsanos et autres

Introduction: The spot sign identified on CT angiography (CTA), is a well-established predictor of hematoma expansion (HE), but its role in FXai-related intracerebral hemorrhage (ICH) remains poorly explored. We investigated the association between spot sign and HE in patients with acute FXai-associated …

ca, it, us, gb, pl, se, es, hu, ch, il, no, dk, nl, be, fr, fi, cz, pt, at (code pays fourni par la source)

Rationale, design and baseline characteristics of participants in the OCEANIC-STROKE trial of FXIa inhibition for secondary stroke prevention

Mukul Sharma, Qiang Dong, Teruyuki Hirano, Scott Eric Kasner et autres

INTRODUCTION: Genetic deficiency of factor XI is associated with a reduced risk of ischemic stroke. Asundexian is a direct inhibitor of activated factor XIa (FXIa) with a low risk of bleeding in early trials. We seek to determine its efficacy and safety …

ca, cn, jp, us, es, fr, hu, gr, de, bg, kr, au, it, tw, ar, cz, be, pt, gb, dk, tr, il, sk, pl, co, my, ch, at, in, fi, nl, lv, lt, se, br, no, kz (code pays fourni par la source)

TRPC4/TRPC5 are critical for neuronal modulation of transcranial focused ultrasound in mouse retrosplenial cortex

Chao Wu, Jie You, Tao Sheng, Guofeng Li et autres

Transcranial focused ultrasound (tFUS) non-invasively regulates neuronal activity, yet its underlying molecular mechanisms remain largely unknown. This study identifies TRPC4 and TRPC5 as critical mediators of tFUS-induced neuronal modulation. Applying tFUS to the retrosplenial cortex (RSC) in male mice desensitizes mechanical and …

cn (code pays fourni par la source)

Rational tuning of temperature sensitivity of the TRPM8 channel

Lizhen Xu, Xiao Liang, Yunfei Wang, Han Wen et autres

Detecting temperature is crucial for the survival of living organisms. Although the temperature sensitive Transient Receptor Potential Melastatin 8 (TRPM8) channel has been identified as the prototypical cold sensor, the mechanisms by which it detects temperature remain elusive. In this study, we …

cn (code pays fourni par la source)

Beyond body mass index: the role of fat distribution in male sperm quality

Dongsheng Ma, Mengru Zhang, Lizhen Xu

Objective To explore the dual role of obesity and fat distribution on sperm dynamics and morphological parameters and to further assess the impact on male fertility. Methods A population of 823 male semen examinations from the Male Reproductive Health Database (FAST-Date, 2022-2025), …

cn (code pays fourni par la source)

Accelerate 3D Object Detection Models via Zero-Shot Attention Key Pruning

Lizhen Xu, Xiuxiu Bai, Xiaojun Jia, Jianwu Fang et autres

Query-based methods with dense features have demonstrated remarkable success in 3D object detection tasks. However, the computational demands of these models, particularly with large image sizes and multiple transformer layers, pose significant challenges for efficient running on edge devices. Existing pruning and …

cn, sg (code pays fourni par la source)

Andexanet alfa for the reversal of the low-molecular-weight heparin enoxaparin

Thijs F. van Haaps, Alexander Philipp Benz, Lizhen Xu, Saskia Middeldorp et autres

Background: Andexanet alfa (andexanet) is the only approved reversal agent for patients with acute major bleeding during apixaban or rivaroxaban treatment. Its mechanism suggests it may also reverse the effects of low-molecular-weight heparin. Aim: To evaluate the effects of andexanet in healthy …

nl, de, ca, us, se, ch, au (code pays fourni par la source)

Decreased RYR2 Cluster Size and Abnormal SR Ca 2+ Release Contribute to Arrhythmogenesis in TMEM43 ‐Related ARVC

Jiaxi Shen, Xiaochen Wang, Hangping Fan, Yaxun Sun et autres

Abstract Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare inherited cardiomyopathy featured by life‐threatening arrhythmias. While TMEM43 has been identified as an ARVC‐associated gene, molecular links between TMEM43 mutations and electrophysiological abnormalities in ARVC remain largely elusive. Here, using induced‐pluripotent‐stem‐cell‐derived cardiomyocytes (iPSC‐CMs) …

cn, Madagascar (code pays fourni par la source)