Marta Gawin

DeisoLAB - isotopic envelope identification by analysis of the spatial distribution of peptides in MALDI-MSI data

Anna Glodek, Marta Gawin, Monika Pietrowska, Joanna Polańska

A new approach (DeisoLAB) is introduced to handle extensive peptide data obtained in mass spectrometry imaging experiments and detect potential isotopic envelopes. It is based on a combination of a fuzzy-inference system and analysis of spatial distribution of peptides. Potential isotopic envelope …

pl (code pays fourni par la source)

Functional and Proteomic Profiles of CD3(+) Plasma‐Derived Small Extracellular Vesicles Differentiate Cancer Patients From Healthy Donors

Piotr Widłak, Jie Han, Alicja Głuszko, Justyna Mika et autres

Small extracellular vesicles (sEV) released by T cells play a key role in immune regulation. Immune capture with anti-CD3 antibodies was used to isolate and study T cell-derived CD3(+)sEV from the plasma of patients with melanoma (MPs) or healthy donors (HDs). Functional …

pl, us, hu (code pays fourni par la source)

Inflammasome Inhibitor MCC950 Attenuates Methamphetamine-Induced Hippocampal Neurotoxicity and Aberrant Neurogenesis in a Sex-Dependent Manner

Mateusz Smolarz, Natalia Pondel, Gracjana Zając, Agata Kurczyk et autres

Methamphetamine (METH) is a known proinflammatory agent; however, the impacts of inflammasomes on its neurotoxic effects are not fully understood. In the present study, we assessed the impact of prolonged METH administration on the hippocampal inflammasome profile in male and female mice …

pl, us (code pays fourni par la source)

DeisoLAB: Application and MALDI-MSI datasets (Part 2/2)

Anna Glodek, Joanna Polańska, Monika Pietrowska, Marta Gawin

DeisoLAB: Application and MALDI-MSI datasets (Part 2/2) Raw MALDI-MSI datasets (HNC-FFPE Dataset 3 and HNC-FFPE Dataset 4)

pl, hu (code pays fourni par la source)

DeisoLAB: Application and MALDI-MSI datasets (Part 2/2)

Anna Glodek, Joanna Polańska, Monika Pietrowska, Marta Gawin

DeisoLAB: Application and MALDI-MSI datasets (Part 2/2) Raw MALDI-MSI datasets (HNC-FFPE Dataset 3 and HNC-FFPE Dataset 4)

pl, hu (code pays fourni par la source)

DeisoLAB

Anna Glodek, Joanna Polańska, Marta Gawin, Monika Pietrowska

DeisoLAB: Application and MALDI-MSI datasets (Part 1/2) This repository contains the DeisoLAB application together with the datasets required to reproduce the workflow presented in the associated publication. The repository includes: DeisoLAB application – the MATLAB implementation of the proposed method. Example dataset …

pl, hu (code pays fourni par la source)

DeisoLAB

Anna Glodek, Joanna Polańska, Marta Gawin, Monika Pietrowska

DeisoLAB: Application and MALDI-MSI datasets (Part 1/2) This repository contains the DeisoLAB application together with the datasets required to reproduce the workflow presented in the associated publication. The repository includes: DeisoLAB application – the MATLAB implementation of the proposed method. Example dataset …

pl, hu (code pays fourni par la source)

DeisoLAB

Anna Glodek, Joanna Polańska, Marta Gawin, Monika Pietrowska

This repository contains the DeisoLAB application together with the files required to reproduce the workflow presented in the associated publication. The repository includes: DeisoLAB application – the MATLAB implementation of the proposed method with exemplary dataset – a prepared example dataset included …

pl, hu (code pays fourni par la source)

Supplementary proteomic datasets (Tables S3-S7) supporting: "Neutrophil-derived EVs drive NF-κB-dependent endothelial activation and tumor angiogenesis"

Mateusz Smolarz, Weronika Jurczyk, Agata Kurczyk, Daniel Fochtmann et autres

This dataset contains supplementary proteomic data presented in Tables S3-S7 of the associated manuscript. The data were obtained from proteomic analyses of ER-HoxB8-derived neutrophils and neutrophil-derived small extracellular vesicles (NEX) isolated from WT and Ifnar1−/− mice, as well as NEX isolated from …

Supplementary proteomic datasets (Tables S3-S7) supporting: "Neutrophil-derived EVs drive NF-κB-dependent endothelial activation and tumor angiogenesis"

Mateusz Smolarz, Weronika Jurczyk, Agata Kurczyk, Daniel Fochtmann et autres

This dataset contains supplementary proteomic data presented in Tables S3-S7 of the associated manuscript. The data were obtained from proteomic analyses of ER-HoxB8-derived neutrophils and neutrophil-derived small extracellular vesicles (NEX) isolated from WT and Ifnar1−/− mice, as well as NEX isolated from …

Inflammasome Inhibitor MCC950 Attenuates Methamphetamine‐Induced Hippocampal Neurotoxicity and Aberrant Neurogenesis

Mateusz Smolarz, Natalia Pondel, Gracjana Zając, Agata Kurczyk et autres

Methamphetamine (METH) is a known proinflammatory agent; however, the impact of inflammasomes on its neurotoxic effects is not fully understood. In the present study, we assessed the impact of a prolonged METH administration on the hippocampal inflammasome profile in male and female …

Plasma-Derived sEVs from HNSCC Patients Differentially Regulate NF-κB Signaling in Macrophages Depending on the HPV Status

Diana Huber, Florian von Strachwitz, Linda Hofmann, Monika Pietrowska et autres

BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) are highly immunosuppressive, and tumor-associated macrophages constitute a major component of HNSCC tumor microenvironments. Here, we investigate the effects of circulating small extracellular vesicles (sEVs) from HNSCC patients on primary macrophages, to elucidate systemic …

de, pl, hu, jp (code pays fourni par la source)