Inflammasome Inhibitor MCC950 Attenuates Methamphetamine-Induced Hippocampal Neurotoxicity and Aberrant Neurogenesis in a Sex-Dependent Manner
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Le résumé fourni par la source
Methamphetamine (METH) is a known proinflammatory agent; however, the impacts of inflammasomes on its neurotoxic effects are not fully understood. In the present study, we assessed the impact of prolonged METH administration on the hippocampal inflammasome profile in male and female mice and determined alterations of the inflammasome profile in response to METH. In addition to inflammasome activation, METH induced both systemic and hippocampal-specific inflammatory responses, leading to cognitive impairment, reduced hippocampal cell proliferation, and altered proteomic profiles. Importantly, the responses to METH exposure exhibited important sexual dimorphism. Treatment with inflammasome inhibitor MCC950 attenuated METH-induced inflammatory events; however, we also observed several off-target effects of this inhibitor affecting mouse anxiety-like behavior and cognitive function. Overall, our results indicate the preventive potential of MCC950 in METH-related neurotoxicity, while underscoring its limitations due to distinct sex-dependent differences in response to both METH and MCC950 and highlighting significant sexual dimorphism.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Inflammasome Inhibitor MCC950 Attenuates Methamphetamine-Induced Hippocampal Neurotoxicity and Aberrant Neurogenesis in a Sex-Dependent Manner
- Date Crossref
- 11/08/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The Maria Sklodowska-Curie National Research Institute of Oncology pays non établi dans la noticeÉtablissement de santé
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University of Miami Department of Biochemistry and Molecular Biology pays non établi dans la noticeUniversité ou école supérieure
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Institute of Physiotherapy and Health Sciences pays non établi dans la noticeStructure de recherche
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Maria Skłodowska-Curie National Research Institute of Oncology Department of Biostatistics and Bioinformatics pays non établi dans la noticeStructure de recherche
The Maria Sklodowska-Curie National Research Institute of Oncology, Department of Biochemistry and Molecular Biology — University of Miami et Institute of Physiotherapy and Health Sciences, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.