Natalia Pondel

Inflammasome Inhibitor MCC950 Attenuates Methamphetamine-Induced Hippocampal Neurotoxicity and Aberrant Neurogenesis in a Sex-Dependent Manner

Mateusz Smolarz, Natalia Pondel, Gracjana Zając, Agata Kurczyk et autres

Methamphetamine (METH) is a known proinflammatory agent; however, the impacts of inflammasomes on its neurotoxic effects are not fully understood. In the present study, we assessed the impact of prolonged METH administration on the hippocampal inflammasome profile in male and female mice …

pl, us (code pays fourni par la source)

Inflammasome Inhibitor MCC950 Attenuates Methamphetamine‐Induced Hippocampal Neurotoxicity and Aberrant Neurogenesis

Mateusz Smolarz, Natalia Pondel, Gracjana Zając, Agata Kurczyk et autres

Methamphetamine (METH) is a known proinflammatory agent; however, the impact of inflammasomes on its neurotoxic effects is not fully understood. In the present study, we assessed the impact of a prolonged METH administration on the hippocampal inflammasome profile in male and female …

Effect of a Nutraceutical Combination on Oxidative Stress Biomarkers in Healthy Subjects and Patients with Alzheimer’s Disease

Rafał Jastrząb, Andrzej Małecki, Elżbieta Kmiecik-Małecka, Agnieszka Gorzkowska et autres

Background/Objectives: Advanced glycation end products (AGEs) and oxidative stress increase with aging and are implicated in Alzheimer’s disease (AD). We developed an anti-glycation blend using LC-MS-based screening and assessed its effects on oxidative and glycation-related biomarkers in humans. Methods: Twelve candidate compounds …

pl (code pays fourni par la source)

Probiotic Lactiplantibacillus plantarum OL3246 supports healthy aging by enhancing quality of life, reducing inflammation, and modulating gut microbiota: a pilot study

Rafał Jastrząb, Andrzej Małecki, Elżbieta Kmiecik-Małecka, Agnieszka Gorzkowska et autres

Aging is accompanied by low-grade intestinal inflammation, shifts in gut microbiota, and impaired oxidative balance. Probiotic supplementation has been proposed to mitigate these processes, yet evidence in elderly populations remains limited. In this pilot trial, older adults received oral Lactiplantibacillus plantarum OL3246 …

pl (code pays fourni par la source)

Effects of voluntary wheel running on appetite-regulating peptides and neuroinflammation in the hypothalamus of ovariectomized middle-aged mice

Mateusz Grabowski, Konstancja Grabowska, Magdalena Kostka, Natalia Pondel et autres

The postmenopausal period is associated with an increased tendency to gain weight. This may be due to disturbances in appetite regulation, mainly in the hypothalamus and nutritional behaviors, as well as persistent neuroinflammation resulting from estrogen deficiency. Research indicates that physical activity …

pl (code pays fourni par la source)

Protective impact of physical exercise on methamphetamine-induced neuroinflammation and neurogenesis impairment depends on the activity level

Mateusz Smolarz, Magdalena Dębiec, Gracjana Zając, Natalia Pondel et autres

One of the outcomes of methamphetamine (METH) misuse is impaired hippocampal function. In addition, regular physical exercise has been proposed as an effective behavioral intervention with numerous health benefits, particularly in the treatment of drug misuse. In this study, we evaluated the …

pl, us (code pays fourni par la source)

Ketogenic diet and behavior: insights from experimental studies

Konstancja Grabowska, Mateusz Grabowski, Marta Przybyła, Natalia Pondel et autres

As a journal page for full details. The ketogenic diet (KD) has been established as a treatment for epilepsy, but more recently it has been explored as an alternative or add-on therapy for many other diseases ranging from weight loss to neurological …

pl, de (code pays fourni par la source)

Effects of Simultaneous Exposure to a Western Diet and Wheel-Running Training on Brain Energy Metabolism in Female Rats

Marta Maria Nowacka-Chmielewska, Daniela Liśkiewicz, Konstancja Grabowska, Arkadiusz Damian Liśkiewicz et autres

BACKGROUND: In the pathogenesis of central nervous system disorders (e.g., neurodegenerative), an important role is attributed to an unhealthy lifestyle affecting brain energy metabolism. Physical activity in the prevention and treatment of lifestyle-related diseases is getting increasing attention. METHODS: We performed a …

pl (code pays fourni par la source)

Differential Response of Hippocampal and Cerebrocortical Autophagy and Ketone Body Metabolism to the Ketogenic Diet

Daniela Liśkiewicz, Arkadiusz Damian Liśkiewicz, Marta Maria Nowacka-Chmielewska, Mateusz Grabowski et autres

Experimental and clinical data support the neuroprotective properties of the ketogenic diet and ketone bodies, but there is still a lot to discover to comprehensively understand the underlying mechanisms. Autophagy is a key mechanism for maintaining cell homeostasis, and therefore its proper …

pl (code pays fourni par la source)

Dieta ketogeniczna - mechanizm działania i perspektywy zastosowania w terapii: dane z badań klinicznych

Natalia Pondel, Daniela Liśkiewicz, Arkadiusz Damian Liśkiewicz

Ketogenic diet is a high fat and very low-carbohydrate nutritional approach that induces increased production of ketone bodies, which serve as an alternative to glucose energetic substrates. Since almost a century ketogenic diet has been used in the therapy of refractory epilepsy, …

pl (code pays fourni par la source)