Praneeth Reddy Kuninty

Mechanosensing-inspired targeted nanosystem rewires heterogenous cancer-associated fibroblasts via CHIP activation in pancreatic ductal adenocarcinoma

Jai Prakash, Ahmed M. R. H. Mostafa, Ahmed Monem Hemdan, Praneeth Reddy Kuninty et autres

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Engineered cyclic peptide targeting ITGA5 disrupts tumor–stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma

Deby Fajar Mardhian, Kunal P. Pednekar, Ahmed Monem Hemdan, Praneeth Reddy Kuninty et autres

The tumor-stroma interaction contributes to the aggressive and resistance nature of pancreatic ductal adenocarcinoma (PDAC), leading to treatment failure. Cancer-associated fibroblasts (CAFs), a key cell type in the stroma, produce abundant extracellular matrix (ECM) and exhibit crosstalk with cancer cells inducing chemoresistance. …

id, nl, Égypte, gb, de (code pays fourni par la source)

Microarchitectural mimicking of stroma-induced vasculature compression in pancreatic tumors using a 3D engineered model

Marcel Alexander Heinrich, Irene Uboldi, Praneeth Reddy Kuninty, Marc J. K. Ankoné et autres

Fibrotic tumors, such as pancreatic ductal adenocarcinoma (PDAC), are characterized for high desmoplastic reaction, which results in high intra-tumoral solid stress leading to the compression of blood vessels. These microarchitectural alterations cause loss of blood flow and poor intra-tumoral delivery of therapeutics. …

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Cancer immune therapy using engineered ‛tail-flipping’ nanoliposomes targeting alternatively activated macrophages

Praneeth Reddy Kuninty, Karin Binnemars‐Postma, Ahmed Jarray, Kunal P. Pednekar et autres

Alternatively-activated, M2-like tumor-associated macrophages (TAM) strongly contribute to tumor growth, invasiveness and metastasis. Technologies to disable the pro-tumorigenic function of these TAMs are of high interest to immunotherapy research. Here we show that by designing engineered nanoliposomes bio-mimicking peroxidated phospholipids that are …

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ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer

Praneeth Reddy Kuninty, Ruchi Bansal, Susanna W.L. de Geus, Deby Fajar Mardhian et autres

Abundant desmoplastic stroma is the hallmark for pancreatic ductal adenocarcinoma (PDAC), which not only aggravates the tumor growth but also prevents tumor penetration of chemotherapy, leading to treatment failure. There is an unmet clinical need to develop therapeutic solutions to the tumor …

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Targeting integrin alpha5 receptor in pancreatic stellate cells to diminish tumor-promoting effects in pancreatic cancer

Praneeth Reddy Kuninty, Ruchi Bansal, Sanne W.L. De Geus, Jonas Schnittert et autres

Abstract Pancreatic stellate cells (PSCs) are the main precursors of cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma (PDAC), known to induce cancer aggressiveness. Integrin alpha5 (ITGA5), a fibronectin receptor, was found to be overexpressed by CAFs in stroma and linked to poor …

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Reprogramming tumor stroma using an endogenous lipid lipoxin A4 to treat pancreatic cancer

Jonas Schnittert, Marcel Alexander Heinrich, Praneeth Reddy Kuninty, Gert Storm et autres

Pancreatic stellate cells (PSCs) are the precursors of cancer-associated fibroblasts (CAFs), which potentiate pancreatic tumor growth and progression. In this study, we investigated whether Lipoxin A4 (LXA4), an endogenous bioactive lipid, can inhibit the differentiation of human PSCs (hPSCs) into CAF-like myofibroblasts …

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Abstract B208: Targeting ITGA5 in pancreatic stellate cells as a novel strategy to restrain pancreatic tumor growth

Praneeth Reddy Kuninty, Sanne de Geus, Ruchi Bansal, Jonas Schnittert et autres

Abstract Pancreatic ductal adenocarcinoma (PDAC) is the deadliest tumor type with a 5-year survival rate of less than 5%. PDAC is characterized by abundant desmoplastic stroma, driving tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) are the key pro-tumorigenic stromal cells in pancreatic …

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Novel targeting strategies against pancreatic stellate cells to treat pancreatic cancer

Praneeth Reddy Kuninty

Pancreatic cancer is the most aggressive tumor type with a 5-year overall survival of only 8% and the median survival time is about 6 months. Chemotherapy is the only option for patients with advanced pancreatic cancer, as only less than 20% tumors …

Anti-MicroRNA Targeting Using Peptide-Based Nanocomplexes to Inhibit Differentiation of Human Pancreatic Stellate Cells

Jonas Schnittert, Praneeth Reddy Kuninty, Tomasz F Bystry, Roland E. Brock et autres

AIM: To develop novel peptide-based nanocomplexes (NCs) for delivery of anti-miRNA oligonucleotides to human-derived pancreatic stellate cells (hPSCs), precursors of cancer-associated fibroblasts. MATERIALS & METHODS: NCs of anti-miRNA oligonucleotides and cell-penetrating peptides (different variants) were formed and characterized. The effects of anti-miR-199a …

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Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC

Carina Strell, K. Jessica Norberg, Artur Mezheyeuski, Jonas Schnittert et autres

BACKGROUND: The HMGA2 protein has experimentally been linked to EMT and cancer stemness. Recent studies imply that tumour-stroma interactions regulate these features and thereby contribute to tumour aggressiveness. METHODS: We analysed 253 cases of pancreatic ductal adenocarcinoma (PDAC) and 155 cases of …

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MicroRNA-199a and -214 as potential therapeutic targets in pancreatic stellate cells in pancreatic tumor

Praneeth Reddy Kuninty, Linda Bojmar, Vegard Tjomsland, Marie Larsson et autres

// Praneeth R. Kuninty 1 , Linda Bojmar 2, 3 , Vegard Tjomsland 2, 4 , Marie Larsson 2 , Gert Storm 1, 5 , Arne Östman 6 , Per Sandström 2 , Jai Prakash 1, 6 1 Department of Biomaterials, Science …

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