Julia Zinngrebe

Adipocytes: Hidden forces of the immune system?

Julia Zinngrebe, Konstantin M. J. Sparrer, Pamela Fischer‐Posovszky

While adipocytes are majorly recognized for their role in energy homeostasis, they recently emerged as regulators of immune functions and defenders against pathogens. This poses the question of whether these lipid-laden cells constitute a currently underappreciated but integral component of our immune …

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Excess body weight at diagnosis is associated with inferior ALL outcome in male adolescents in the ALL-BFM 2000 study

Martin Zimmermann, Christian Denzer, Anja Möricke, Julia Alten et autres

Upregulation of miR-146a-5p and miR-146b-5p limits IL-1β-mediated signaling in adipose tissue during polytrauma by downregulating IRAK1

Antonia Mortsch, Julian Roos, Rebecca Halbgebauer, Ludmila Lupu et autres

MicroRNAs (miRNAs) are small non-coding RNAs and play a crucial role in the regulation of inflammation. White adipose tissue (WAT) covers the body and internal organs in subcutaneous and visceral fat depots, respectively, and represents an important source of circulating miRNAs. The …

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Response to “Co-Culture Shock” by Behan & Mittelman: Co-culture shock? Let’s integrate!

Julia Zinngrebe, Pamela Fischer‐Posovszky

We thank Drs. Behan and Mittelman for their interest in our recent publication “Bridging the marrow: a co-culture-platform of leukemia cells and MS5-derived stromal cells or adipocytes” [ 1 ]. We greatly appreciate their opinion and the extensive body of work they …

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Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome

Ximena Hildebrandt, Önay Veli, Armel Hyoubi, Julia Zinngrebe et autres

Adipocyte hypertrophy during obesity triggers chronic inflammation, leading to metabolic disorders. However, the role of adipocyte-specific inflammatory signaling in metabolic syndrome remains unclear. The linear ubiquitin chain assembly complex, LUBAC, is an E3-ligase that generates nondegradative linear ubiquitination (Lin-Ub). LUBAC regulates NF-κB/MAPK-driven …

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Bridging the marrow: a co-culture-platform of leukemia cells and MS5-derived stromal cells or adipocytes

Julia Zinngrebe, Elena Dorothea Brenner, Ferdinand Schlichtig, Ulrich Stifel et autres

In the context of acute lymphoblastic leukemia (ALL), the bone marrow microenvironment (BMM) plays a crucial role in providing pro-survival signals, as evident from the rapid spontaneous cell death observed in ex-vivo cultures of primary ALL cells. Among the diverse cell types …

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GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration

Dan Pascal Jean Albers, Julio Vieyto‐Nuñez, Yasser Almeida‐Hernández, Chiara Pastorio et autres

BACKGROUND: GPR15LG, a chemokine-like ligand for the G-protein coupled receptor 15 (GPR15), is abundantly expressed in the gastrointestinal mucosa and inflamed skin. Emerging evidence suggests its involvement in inflammatory disorders and cancers. C-X-C chemokine receptor type 4 (CXCR4) plays a critical role …

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Distinct pathogenic mutations in ARF1 allow dissection of its dual role in cGAS-STING signalling

Johannes Lang, Tim Bergner, Julia Zinngrebe, Alice Lepelley et autres

Tight control of cGAS-STING-mediated DNA sensing is crucial to avoid auto-inflammation. The GTPase ADP-ribosylation factor 1 (ARF1) is crucial to maintain cGAS-STING homeostasis and various pathogenic ARF1 variants are associated with type I interferonopathies. Functional ARF1 inhibits STING activity by maintaining mitochondrial …

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Homozygous OTULIN Variant Linked to OTULIN-Related Autoinflammatory Syndrome with Abscess Formation

Salma Alkhammash, Thomas Monecke, Barbara Moepps, Doaa Bajaber et autres

Abstract Homozygous OTU deubiquitinase with linear linkage specificity (OTULIN) variants cause OTULIN-Related Autoinflammatory Syndrome (ORAS). This disease is characterized by early-onset autoinflammation, fever, panniculitis, diarrhea, and arthritis. In contrast, heterozygous and compound-heterozygous OTULIN variants have been associated with a phenotype defined by …

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SEVI Fibrils are Induced by Bacterial Surface Molecules and Exert Antimicrobial Activity Against ESKAPE Pathogens

Verena Vogel, Lia-Raluca Olari, Richard H. Bauer, Sandra Burczyk et autres

Abstract The semen-derived enhancer of viral infection (SEVI) is an amyloid fibril formed by the self-assembly of the PAP248-286 peptide, a cleavage product of prostatic acid phosphatase, which is naturally present in human seminal plasma. Beyond its previously described role in HIV …

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GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration

Dan Pascal Jean Albers, Julio Vieyto‐Nuñez, Yasser Almeida‐Hernández, Chiara Pastorio et autres

Abstract GPR15LG, a chemokine-like ligand for the G-protein coupled receptor 15 (GPR15), is abundantly expressed in the gastrointestinal mucosa and inflamed skin. Emerging evidence suggests its involvement in inflammatory disorders and cancers. This study investigates the effects of GPR15LG on the signaling …

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Brown adipose tissue fights the battle against leukaemia

Pamela Fischer‐Posovszky, Julia Zinngrebe

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