Hathairat Thananchai

VEGF-A Gene Expression Profiling in Northern Thai Gastric Cancer Patients and Potential for Anti-VEGF Therapy

Amonnat Sukhamwang, Hathairat Thananchai, Peticha Tanprasert, Pornngarm Limtrakul et autres

Background/Objectives: Gastric cancer (GC) remains a major burden in Northern Thailand. Elevated interleukin-8 (IL-8) and vascular endothelial growth factor A (VEGF-A) expression are linked with poor prognosis and tumor progression in gastric cancer. However, the concordance of VEGF-A and IL-8 gene expression …

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VEGF-A Gene Expression Profiling in Northern Thai Gastric Cancer Patients and Potential for Anti-VEGF Therapy

Amonnat Sukhamwang, Hathairat Thananchai, Peticha Tanprasert, Pornngarm Limtrakul et autres

Background/Objectives: Gastric cancer (GC) remains a major health burden in Northern Thailand. Elevated expression of interleukin-8 (IL-8) and vascular endothelial growth factor A (VEGF-A) is often associated with poor prognosis and tumor progression in gastric cancer. However, the concurrent expression of VEGF-A …

Phytochemical Characterization and Immunometabolic Modulation by Mangifera indica (Mahajanaka) Pulp Extract in Diabetic and Hypertensive Rat Models

Wachiraporn Tipsuwan, Hathairat Thananchai, Anusara Pongjanta, Suphatta Yubo et autres

Mango (Mangifera indica L.) pulp contains bioactive compounds with potential therapeutic effects against metabolic and immune-related disorders. However, the integrated effects of mango pulp extract on metabolic, cardiovascular, and immunomodulatory functions remain insufficiently characterized. Therefore, this study aimed to characterize the phytochemical …

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Abstract 5918: Vascular endothelial growth factor A (VEGF-A) gene expression profiling in Northern Thai gastric cancer patients and potential biomarker for anti-VEGF therapy selection

Amonnat Sukhamwang, Hathairat Thananchai, Supachai Yodkeeree, Sirikan Limpakan

Abstract Background: Vascular endothelial growth factor (Anti-VEGF) drugs are used to treat advanced-stage gastric cancer to inhibit angiogenesis, which is the process of new blood vessel formation that tumors need to grow. These drugs have improved progression-free survival and overall survival when …

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A molecular epidemiological analysis of Burkholderia pseudomallei in southern Thailand

Jedsada Kaewrakmuk, Sarunyou Chusri, Pacharapong Khrongsee, Soontara Kawila et autres

Melioidosis, a severe bacterial illness caused by Burkholderia pseudomallei, is prevalent in most parts of Thailand, including its southern region situated within the Malay Peninsula. Despite a lower reported incidence rate of melioidosis in the South compared to the Northeast, the mortality …

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Antibacterial activities of Miang extracts against selected pathogens and the potential of the tannin-free extracts in the growth inhibition of Streptococcus mutans

Aliyu Dantani Abdullahi, Kridsada Unban, Chalermpong Saenjum, Pratthana Kodchasee et autres

Bacterial pathogens have remained a major public health concern for several decades. This study investigated the antibacterial activities of Miang extracts (at non-neutral and neutral pH) against Bacillus cereus TISTR 747, Escherichia coli ATCC 22595, Salmonella enterica serovar Typhimurium TISTR 292 and …

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Benchmarking CRISPR-BP34 for point-of-care melioidosis detection in low-income and middle-income countries: a molecular diagnostics study

Sukripong Pakdeerat, Phumrapee Boonklang, Kesorn Angchagun, Chalita Chomkatekaew et autres

BACKGROUND: Melioidosis is a neglected but often fatal tropical disease. The disease has broad clinical manifestations, which makes diagnosis challenging and time consuming. To improve diagnosis, we aimed to evaluate the performance of the CRISPR-Cas12a system (CRISPR-BP34) to detect Burkholderia pseudomallei DNA …

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Under-Reporting Cases and Deaths from Melioidosis: A Retrospective Finding in Songkhla and Phatthalung Province of Southern Thailand, 2014–2020

Jedsada Kaewrakmuk, Sarunyou Chusri, Thanaporn Hortiwakul, Soontara Kawila et autres

, is a notifiable disease associated with a high mortality rate in Thailand. The disease is highly endemic in northeast Thailand, while its prevalence in other parts of the country is poorly documented. This study aimed at improving the surveillance system for …

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Benchmarking CRISPR-BP34 for point-of-care melioidosis detection in LMIC: a molecular diagnostics study

Sukripong Pakdeerat, Phumrapee Boonklang, Kesorn Angchagun, Chalita Chomkatekaew et autres

Summary Background Melioidosis is a grossly neglected but often-fatal tropical disease. The disease is named “a great mimicker” after its broad clinical manifestations, which makes disease diagnosis challenging and time-consuming. To improve diagnosis, we developed and evaluated the performance of the CRISPR-Cas12a …

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Alteration of monocyte subsets and their functions in thalassemia patients

Thanakrit Piyajaroenkij, Adisak Tantiworawit, Jeeraphong Khikhuntod, Pokpong Piriyakhuntorn et autres

Infection is one of the leading causes of mortality in thalassemia patients. This study aimed to examine qualitative and quantitative changes in monocytes in thalassemia patients. Monocytes were isolated from peripheral blood mononuclear cells and separated into subpopulations by flow cytometry. Cytokine …

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Highly specific and sensitive detection of Burkholderia pseudomallei genomic DNA by CRISPR-Cas12a

Somsakul Pop Wongpalee, Hathairat Thananchai, Claire Chewapreecha, Henrik B. Roslund et autres

Detection of Burkholderia pseudomallei, a causative bacterium for melioidosis, remains a challenging undertaking due to long assay time, laboratory requirements, and the lack of specificity and sensitivity of many current assays. In this study, we are presenting a novel method that circumvents …

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Attempt to Isolate Elephant Endotheliotropic Herpesvirus (EEHV) Using a Continuous Cell Culture System

Kornravee Photichai, Thunyamas Guntawang, Tidaratt Sittisak, Varankpicha Kochagul et autres

). Until recently, in vitro isolation and propagation of the virus have not been successful. This study aimed to isolate and propagate EEHV using continuous cell lines derived from human and/or animal origins. Human cell lines, including EA. hy926, A549, U937, RKO, …

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