Somsakul Pop Wongpalee

Corrigendum to “Targeting PD-L1 and disrupting Siglec-9 cooperatively potentiate macrophage phagocytosis of breast cancer via a trispecific macrophage engager (TriME)” [Biomed. Pharmacother. 200 (2026), 119609]

Saitong Muneekaew, Aussara Panya, Kritayaporn Saiprayong, Koollawat Chupradit et autres

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Targeting PD-L1 and disrupting Siglec-9 cooperatively potentiate macrophage phagocytosis of breast cancer via a trispecific macrophage engager (TriME)

Saitong Muneekaew, Aussara Panya, Kritayaporn Saiprayong, Koollawat Chupradit et autres

Breast cancer (BC) remains a leading cause of mortality, highlighting the need for novel immunotherapies capable of overcoming treatment resistance. Programmed death-ligand 1 (PD-L1) is recognized as a therapeutic target, particularly within aggressive subtypes like triple-negative breast cancer (TNBC). To effectively leverage …

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CRISPR-based environmental detection of Burkholderia pseudomallei identifies sanitation gaps and melioidosis risk in northeast Thailand

Sukritpong Pakdeerat, Chalita Chomkatekaew, Phumrapee Boonklang, Raiwin Mothong et autres

Environmental exposure to Burkholderia pseudomallei, the causative agent of melioidosis, remains poorly characterised due to the low sensitivity of conventional detection methods. Here, we develop CRISPR-BEEPs, a sensitive and resource-efficient CRISPR-based assay, and evaluate its performance against conventional culture-based plate inspection using …

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CRISPR-based environmental detection of Burkholderia pseudomallei identifies sanitation gaps and melioidosis risk in northeast Thailand.

Sukritpong Pakdeerat, Chalita Chomkatekaew, Phumrapee Boonklang, Raiwin Mothong et autres

Environmental exposure to Burkholderia pseudomallei, the causative agent of melioidosis, remains poorly characterised due to the low sensitivity of conventional detection methods. Here, we develop CRISPR-BEEPs, a sensitive and resource-efficient CRISPR-based assay, and evaluate its performance against conventional culture-based plate inspection using …

Genetic variation in olfactory pathways associated with host-seeking behavior in natural populations of Anopheles minimus, a primary malaria vector in western Thailand

Kanchon Pusawang, Daibin Zhong, Patchara Sriwichai, Yudthana Samung et autres

BACKGROUND: ), host odor, and body heat acting as key attractants. Along the Thai-Myanmar border, Anopheles minimus (the Funestus Group), a primary malaria vector, exhibits a stronger preference for human hosts than species of the Maculatus Group. Elucidating the genetic basis of …

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Anti-CD47 tri-specific killer engager enhances NK cell cytotoxicity against lung cancer

Chutipa Chiawpanit, Yupanun Wutti-In, Somsakul Pop Wongpalee, Ratchaneewan Sumankan et autres

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CRISPR-based environmental detection of Burkholderia pseudomallei identifies sanitation gaps and melioidosis risk in northeast Thailand

Sukritpong Pakdeerat, Chalita Chomkatekaew, Phumrapee Boonklang, Arin Wongprommoon et autres

Abstract Environmental exposure to Burkholderia pseudomallei , the causative agent of melioidosis, remains poorly characterised due to the limited sensitivity of conventional detection methods. This hinders accurate risk mapping and delays public health responses. Here, we developed CRISPR-BEEPs – a sensitive, equipment-light …

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Erythropoiesis and Gene Expression Analysis in Erythroid Progenitor Cells Derived from Patients with Hemoglobin H/Constant Spring Disease

Narawich Wongkhammul, Pinyaphat Khamphikham, Siripong Tongjai, Adisak Tantiworawit et autres

Hemoglobin H/Constant Spring (Hb H/CS) disease represents a form of non-deletional Hb H disease characterized by chronic hemolytic anemia that ranges from moderate to severe and may lead to transfusion-dependent thalassemia. To study the underlying mechanisms of this disease, we conducted an …

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Genetic modifications of EGLN1 reactivate HbF production in β0-thalassemia/HbE

Varit Jan‐ngam, Siriraj Boontha, Alisa Tubsuwan, Somsakul Pop Wongpalee et autres

Reactivation of fetal hemoglobin (HbF, α 2 γ 2 ) potentially alleviates clinical presentation in β-thalassemia. Prolyl hydroxylase domain enzymes (PHDs) play roles in the canonical oxygen-sensing pathway and maintain the stability of cellular hypoxia-inducible factor α (HIF-α) in response to low …

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Probiotic Limosilactobacillus reuteri KUB-AC5 decreases urothelial cell invasion and enhances macrophage killing of uropathogenic Escherichia coli in vitro study

Arishabhas Tantibhadrasapa, Songbo Li, Songphon Buddhasiri, Chutikarn Sukjoi et autres

Introduction Bacterial urinary tract infections (UTI) are among the most common infectious diseases worldwide. The rise of multidrug-resistant (MDR) uropathogenic Escherichia coli (UPEC) UTI cases is a significant threat to healthcare systems. Several probiotic bacteria have been proposed as an alternative to …

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Benchmarking CRISPR-BP34 for point-of-care melioidosis detection in low-income and middle-income countries: a molecular diagnostics study

Sukripong Pakdeerat, Phumrapee Boonklang, Kesorn Angchagun, Chalita Chomkatekaew et autres

BACKGROUND: Melioidosis is a neglected but often fatal tropical disease. The disease has broad clinical manifestations, which makes diagnosis challenging and time consuming. To improve diagnosis, we aimed to evaluate the performance of the CRISPR-Cas12a system (CRISPR-BP34) to detect Burkholderia pseudomallei DNA …

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Antennal morphology and sensilla ultrastructure of the malaria vectors, Anopheles maculatus and An. sawadwongporni (Diptera: Culicidae)

Kanchon Pusawang, Patchara Sriwichai, Kittipat Aupalee, Thippawan Yasanga et autres

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