Nina Frederike Jeppesen Edin

Cell survival and DNA damage along the distal edge of the proton Bragg peak

Anne Marit Rykkelid, Hilde Solesvik Skeie, Vera Helene Tormodsrud, S. Siem et autres

PURPOSE: Proton therapy employs a spread‑out Bragg peak (SOBP) to cover the tumor. Individual protons can reach high linear energy transfer (LET) near the end of their tracks across the SOBP, while the dose‑averaged LET remains low to moderate. Mean LET or …

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Cell survival and DNA damage along the distal edge of the proton Bragg peak

Anne Marit Rykkelid, Hilde Solesvik Skeie, Vera Helene Tormodsrud, S. Siem et autres

Proton therapy employs a spread‑out Bragg peak (SOBP) to cover the tumor. Individual protons can reach high linear energy transfer (LET) near the end of their tracks across the SOBP, while the dose‑averaged LET remains low to moderate. Mean LET or a …

Cell survival and DNA damage along the distal edge of the proton Bragg peak

Anne Marit Rykkelid, Hilde Solesvik Skeie, Vera Helene Tormodsrud, S. Siem et autres

Proton therapy employs a spread‑out Bragg peak (SOBP) to cover the tumor. Individual protons can reach high linear energy transfer (LET) near the end of their tracks across the SOBP, while the dose‑averaged LET remains low to moderate. Mean LET or a …

DIFFERENTIAL INFLAMMATORY RESPONSE AND TISSUE DAMAGE IN MOUSE HEAD AND NECK FOLLOWING PROTON VERSUS X-RAY RADIOTHERAPY

Nina Frederike Jeppesen Edin, Olga Zlygosteva, Inga Solgård Juvkam, Hilde Kanli Galtung et autres

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ENHANCING IMMUNOTHERAPY WITH PROTON- VS X-IRRADIATION IN MOUSE TUMOR MODELS

Anne Marit Rykkelid, Michael R. Horsman, Brita Singers Sørensen, Nina Frederike Jeppesen Edin et autres

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Integrating 2D dosimetry and cell survival analysis for predicting local effect in spatially fractionated radiotherapy

Delmon Arous, Jacob Larsen Lie, Nina Frederike Jeppesen Edin, Eirik Malinen

BACKGROUND AND PURPOSE: Robust methods for analysis and prediction of local cell survival after spatially fractionated radiotherapy (SFRT) in vitro remain limited. We present a methodology integrating spatial dosimetry with colony formation assessment and modelling to improve prediction of SFRT-induced responses. Patient/material …

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CNN-based prediction using early post-radiotherapy MRI as a proxy for toxicity in the murine head and neck

Bao Ngoc Huynh, Manish Kakar, Olga Zlygosteva, Inga Solgård Juvkam et autres

BACKGROUND AND PURPOSE: Radiotherapy (RT) of head and neck cancer can cause severe toxicities. Early identification of individuals at risk could enable personalized treatment. This study evaluated whether convolutional neural networks (CNNs) applied to Magnetic Resonance (MR) images acquired early after irradiation …

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Regional atrophy, cellular plasticity, and regenerative potential in irradiated murine salivary glands

Inga Solgård Juvkam, Olga Zlygosteva, Olav Schreurs, Nina Frederike Jeppesen Edin et autres

BACKGROUND AND PURPOSE: Radiotherapy of head and neck cancer may cause detrimental late side effects such as fibrosis and hyposalivation. We investigated mouse salivary glands after fractionated irradiation, with the aim to elucidate cellular plasticity and potential regeneration. METHODS: 12-week-old female C57BL/6JRj …

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2348 DNA damage response inhibitors enhance interferon signaling in an LET-dependent manner after irradiation of glioblastoma cells

Gro Elise Rødland, Mihaela Temelie, Adrian Eek Mariampillai, Ana Maria Serban et autres

2917 Cellular responses in murine salivary glands to fractionated irradiation: implications for fibrosis and hyposalivation

Inga Solgård Juvkam, Olga Zlygosteva, Eirik Malinen, Nina Frederike Jeppesen Edin et autres

1242 Attention-based vision classifier to predict late radiation toxicity from MR images acquired early after radiotherapy of a murine model

Manish Kakar, Bao Ngoc Huynh, Olga Zlygosteva, Inga Solgård Juvkam et autres

Attention-based Vision Transformer Enables Early Detection of Radiotherapy-Induced Toxicity in Magnetic Resonance Images of a Preclinical Model

Manish Kakar, Bao Ngoc Huynh, Olga Zlygosteva, Inga Solgård Juvkam et autres

IntroductionEarly identification of patients at risk for toxicity induced by radiotherapy (RT) is essential for developing personalized treatments and mitigation plans. Preclinical models with relevant endpoints are critical for systematic evaluation of normal tissue responses. This study aims to determine whether attention-based …

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