Christopher Dravis

Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development

Roger S. Lasken, Richard E. Heinz, Rajshekhar R. Giraddi, Katherine Elena Varley et autres

us (code pays fourni par la source)

The molecular chronology of mammary epithelial cell fate switching

Queralt Vallmajó-Martín, Zhibo Ma, Sumana Srinivasan, Divya Murali et autres

Summary The adult mammary gland is maintained by lineage-restricted progenitor cells through pregnancy, lactation, involution, and menopause. Injury resolution, transplantation-associated mammary gland reconstitution, and tumorigenesis are unique exceptions, wherein mammary basal cells gain the ability to reprogram to a luminal state. Here, …

us (code pays fourni par la source)

Abstract LB223: The molecular landscape of injury-induced mammary epithelial cell fate switching

Queralt Vallmajó Martín, Nikki K. Lytle, Divya Murali, Sumana Srinivasan et autres

Abstract The most aggressive cancers, such as triple negative basal-like breast cancer (TNBC), have high intratumoral heterogeneity that is often attributed to cell state reprogramming and contributes to cancer progression, treatment resistance, and ultimately cancer death. Tissue injury and microenvironmental changes can …

us (code pays fourni par la source)

Abstract A069: The molecular landscape of injury-induced mammary epithelial cell fate switching

Queralt Vallmajó-Martín, Nikki K. Lytle, Divya Murali, Sumana Srinivasan et autres

Abstract The most aggressive cancers, such as triple negative basal-like breast cancer (TNBC), have high intratumoral heterogeneity that is often attributed to cell state reprogramming and contributes to cancer progression, treatment resistance, and ultimately cancer death. Tissue injury and microenvironmental changes can …

us (code pays fourni par la source)

Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells

Benjamin T. Spike, Christopher Dravis, Geoffrey M. Wahl, Joshua Chuck Harrell et autres

SummaryTo discover mechanisms that mediate plasticity in mammary cells, we characterized signaling networks that are present in the mammary stem cells responsible for fetal and adult mammary development. These analyses identified a signaling axis between FGF signaling and the transcription factor Sox10. …

us (code pays fourni par la source)

Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer

John R. Christin, Chunhui Wang, Chi-Yeh Chung, Yu Liu et autres

LSPC determinant SOX9 acts as a lineage plasticity driver for BLBC progression.

us, cn (code pays fourni par la source)

Abstract ES10-2: Understanding breast cancer using a developmental perspective

GM Wahl, Zhibo Ma, Chi‐Yeh Chung, Christopher Dravis et autres

Abstract Parallels among embryonic development, stem cells, and cancer have long been recognized. We identified, isolated, and characterized stem cells that first become committed to a mammary fate during embryogenesis; we refer to these cells as fetal mammary stem cells (fMaSCs). Lineage …

us (code pays fourni par la source)

Single-Cell Chromatin Analysis of Mammary Gland Development Reveals Cell-State Transcriptional Regulators and Lineage Relationships

Chi‐Yeh Chung, Zhibo Ma, Christopher Dravis, Sebastian Preißl et autres

Technological improvements enable single-cell epigenetic analyses of organ development. We reasoned that high-resolution single-cell chromatin accessibility mapping would provide needed insight into the epigenetic reprogramming and transcriptional regulators involved in normal mammary gland development. Here, we provide a single-cell resource of chromatin …

us (code pays fourni par la source)

Single-cell chromatin accessibility analysis of mammary gland development reveals cell state transcriptional regulators and cellular lineage relationships

Chi‐Yeh Chung, Zhibo Ma, Christopher Dravis, Sebastian Preißl et autres

Summary It has only recently become possible to obtain single-cell level resolution of the epigenetic changes that occur during organ development. We reasoned that precision single-cell chromatin accessibility mapping of mammary gland development could provide needed insight into the epigenetic reprogramming and …

us (code pays fourni par la source)

Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity

Christopher Dravis, Chi‐Yeh Chung, Nikki K. Lytle, Jaslem Herrera-Valdez et autres

us (code pays fourni par la source)

Abstract B64: Sox10 drives tumor progression in breast cancer by reprogramming mammary tumor cells into a state of plasticity resembling primitive neural crest cells

Christopher Dravis, Geoffrey M. Wahl

Abstract Many foundational features of tumor malignancy such as tumor initiation, tumor heterogeneity, therapeutic resistance, and metastasis are driven through dysregulated cell plasticity. Thus, the development of strategies to counter mechanisms of reprogramming in cancer cells is a critical area of need …

us (code pays fourni par la source)

Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development

Rajshekhar R. Giraddi, Chi-Yeh Chung, Richard E. Heinz, Ozlen Balcioglu et autres

The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge of developmental kinetics and mechanisms of lineage specification is lacking. We address this significant knowledge gap by generating a single-cell transcriptome atlas …

us (code pays fourni par la source)