Lisa Warsinger Martin

Trimethylamine-N-Oxide (TMAO)-Dietary Pattern Associated With Increased Risk of Atherosclerotic Cardiovascular Disease (ASCVD) in Postmenopausal Women

Kaelyn F Burns, Wenjia Zhu, Michael J. LaMonte, Rachael J Hageman Blair et autres

that fatty acid balance may play an important role in cognitive and school-related functioning.Differences by HIV status indicate that biological vulnerability may modify these relationships.Overall, these results highlight the importance of fatty acid composition when evaluating possible nutritional interventions to support neurodevelopment …

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cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

Eric Van Buren, Yi Zhang, Xihao Li, Margaret Sunitha Selvaraj et autres

us, cn, tw, it, dk, as, ws, ca, br (code pays fourni par la source)

Immediate physical therapy is beneficial for adolescent athletes with active lumbar spondylolysis: a multicentre randomised trial

Mitchell Selhorst, Emily A. Sweeney, Lisa Warsinger Martin, Jingzhen Ginger Yang et autres

OBJECTIVES: To compare the effects of initiating physical therapy (PT) immediately versus resting before starting PT on pain and dysfunction over 12 months in adolescent athletes (10-19 years) with active lumbar spondylolysis. METHODS: This prospective multicentre trial randomised participants to immediate PT …

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Baseline use of aspirin or statins with oral estrogen and progestogens to prevent incident arterial or venous thrombotic events: a secondary analysis of the Women’s Health Initiative trial

John W. Davis, Aaron K. Aragaki, Laura B. Harrington, Jacques E. Rossouw et autres

OBJECTIVE: To evaluate whether effects of oral hormone therapy (HT) on risks of venous and arterial vascular events differ by baseline statin or aspirin use. METHODS: We performed time-to-event analysis using data from the Women's Health Initiative menopausal HT randomized trials to …

us, Afrique du Sud (code pays fourni par la source)

Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies

Brian E. Cade, Paul S. de Vries, Gina Marie Peloso, Jeffrey R. O’Connell et autres

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Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals

Margaret Sunitha Selvaraj, Xihao Li, Zilin Li, Eric Van Buren et autres

BACKGROUND: Rare genetic variation provided by whole genome sequence datasets has been relatively less explored for its contributions to human traits. Meta-analysis of sequencing data offers advantages by integrating larger sample sizes from diverse cohorts, thereby increasing the likelihood of discovering novel …

us, it, tw, ch, ws, dk (code pays fourni par la source)

Long-Term Effect of Cocoa Extract Supplementation on Incident Hypertension

Rikuta Hamaya, Sidong Li, Jessica Lau, Matthew Allison et autres

BACKGROUND: Cocoa flavanols have potential blood pressure (BP)-lowering effects in shorter-term, smaller-scale randomized clinical trials, but their effect on incident hypertension has not been examined in a large-scale and long-term randomized clinical trial. METHODS: The COSMOS (Cocoa Supplement and Multivitamin Outcomes Study) …

us, cn, mm (code pays fourni par la source)

cellSTAAR: Incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of non-coding regions

Eric Van Buren, Yi Zhang, Xihao Li, Margaret Sunitha Selvaraj et autres

Abstract Whole genome sequencing (WGS) studies have identified hundreds of millions of rare variants (RVs) and have enabled RV association tests (RVATs) of these variants with complex traits and diseases. Analysis of non-coding variants is challenged by the considerable variability in regulatory …

us, cn, tw, it, dk, np, ws (code pays fourni par la source)

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Seung Hoan Choi, Sean J. Jurgens, Ling Xiao, Matthew C. Hill et autres

us, nl, is, de, no, se, ch, li, ca, au, jp, dk, gb (code pays fourni par la source)

Long-Term Changes to Cardiovascular Biomarkers After Hormone Therapy in the Women's Health Initiative Hormone Therapy Clinical Trials

Matthew S. Nudy, Aaron K. Aragaki, Xuezhi Jiang, JoAnn E. Manson et autres

OBJECTIVE: To assess the long-term changes in cardiovascular biomarkers during the WHI (Women's Health Initiative) hormone therapy (HT) clinical trials of conjugated equine estrogens (CEE) alone and CEE plus medroxyprogesterone acetate (MPA). METHODS: HT trial participants from the CEE alone (n=1,188, 0.625 …

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A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations

Songmi Lee, Clint L. Miller, Amy R. Bentley, Michael R. Brown et autres

kr, us, nl, fr, is, gb, jp, au, fi, br, it, at, sg, ca, de, cn, li, ch (code pays fourni par la source)

A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

Xihao Li, Han Chen, Margaret Sunitha Selvaraj, Eric Van Buren et autres

us, tw, dk, ws, ca (code pays fourni par la source)