Accès ouvert
2026
article
OpenAlex
Kaleigh A. Connors, Maris R. Pedlow, Zachary D. Frey, Marjorie Cornejo Pontelli et autres
Oropouche fever is a re-emerging global viral threat caused by infection with Oropouche virus (OROV). While disease is generally self-limiting, historical and recent reports of neurologic involvement highlight the importance of understanding the neuropathogenesis of OROV. In this study, we characterize viral …
us
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Accès ouvert
2026
article
OpenAlex
Kaleigh A. Connors, Zachary D. Frey, Matthew J. Demers, Morgan Midgett et autres
ABSTRACT Neuronal injury and death contribute to long-term impairments and lethality during viral encephalitis. Rift Valley fever virus (RVFV), an arbovirus with epidemic potential, can manifest as late-onset encephalitis in humans, yet this disease outcome remains understudied. A lethal rodent model of …
us
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Accès ouvert
2025
article
OpenAlex
Zachary D. Frey, David Anthony Price, Kaleigh A. Connors, Rachael E. Rush et autres
Jamestown Canyon virus (JCV) is a bunyavirus and arbovirus that causes viral neuroinvasive disease in North America. JCV neuropathogenesis is understudied, and no pro-viral host factors for cellular infection have been identified. Here, we assessed the role of low-density lipoprotein receptor-related protein …
us
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Accès ouvert
2024
preprint
OpenAlex
Zachary D. Frey, David Anthony Price, Kaleigh A. Connors, Rachael E. Rush et autres
Jamestown Canyon virus (JCV) is a bunyavirus and arbovirus responsible for neuroinvasive disease in the United States. Little is known about JCV pathogenesis, and no host factors required for cellular infection have been identified. Recently, we identified low-density lipoprotein receptor related protein …
us
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Accès ouvert
2024
preprint
OpenAlex
Kaleigh A. Connors, Maris R. Pedlow, Zachary D. Frey, Jackson J. McGaughey et autres
Oropouche fever is a re-emerging global viral threat caused by infection with Oropouche orthobunyavirus (OROV). While disease is generally self-limiting, historical and recent reports of neurologic involvement highlight the importance of understanding the neuropathogenesis of OROV. In this study, we characterize viral …
us
(code pays fourni par la source)
2024
article
OpenAlex
Kamwing Jair, Stephen E. Abbott, Annette M. Aldous, Karina I. Rivas et autres
OBJECTIVE: The aim of the study is to determine the prevalence of high-risk human papillomavirus (hrHPV) genotypes in men who have sex with other men and are living with HIV and the factors associated with anal high-grade squamous intraepithelial lesions (HSIL). METHODS: …
us
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Accès ouvert
2024
article
OpenAlex
Kaleigh A. Connors, Nathaniel S. Chapman, Cynthia M. McMillen, Ryan M. Hoehl et autres
Rift Valley fever (RVF) is an emerging arboviral disease affecting both humans and livestock. In humans, RVF displays a spectrum of clinical manifestations, including encephalitis. To date, there are no FDA-approved vaccines or therapeutics for human use, although several are in preclinical …
us, fr
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Accès ouvert
2024
article
OpenAlex
Kaleigh A. Connors, Zachary D. Frey, Zachary P. Wills, Amy L. Hartman
Rift Valley fever virus (RVFV) is an emerging arboviral disease with pandemic potential. While infection is often self-limiting, a subset of individuals may develop late-onset encephalitis, accounting for up to 20 % of severe cases. Importantly, individuals displaying neurologic disease have up …
us
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Accès ouvert
2023
article
OpenAlex
Madeline M. Schwarz, Safder S. Ganaie, Annie Feng, G. Schuyler Brown et autres
Rift Valley fever virus (RVFV) is an emerging arbovirus found in Africa. While RVFV is pantropic and infects many cells and tissues, viral replication and necrosis within the liver play a critical role in mediating severe disease. The low-density lipoprotein receptor-related protein …
us
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Accès ouvert
2023
article
OpenAlex
Jeanne A. Jordan, Karina I. Rivas, Annette M. Aldous, Kaleigh A. Connors et autres
OBJECTIVES: The aim of the study is to determine whether a positive OncoE6 Anal Test result has statistically significant higher odds of being associated with high-grade squamous intraepithelial lesion (HSIL) and to calculate sensitivity and specificity of this test for predicting HSIL …
us
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Accès ouvert
2022
article
OpenAlex
Madeline M. Schwarz, Kaleigh A. Connors, Katherine Anne Davoli, Cynthia M. McMillen et autres
Rift Valley fever virus (RVFV) infection leads to eye damage in humans in up to 10% of reported cases. Permanent blindness occurs in 50% of individuals with significant retinal scarring. Despite the prevalence and severity of this outcome, very little is known …
us
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Accès ouvert
2022
review
OpenAlex
Kaleigh A. Connors, Amy L. Hartman
Rift Valley fever virus (RVFV) is an emerging arboviral pathogen that causes disease in both livestock and humans. Severe disease manifestations of Rift Valley fever (RVF) in humans include hemorrhagic fever, ocular disease, and encephalitis. This review describes the current understanding of …
us
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