Accès ouvert
2026
article
OpenAlex
Keiko Tomiyama, Izumi Fukuda, Shigeyuki Tahara, Chie Inomoto et autres
Summary: A 29-year-old male presented with central scotoma and was suspected of having acromegaly based on enlargement of facial features and extremities. Serum growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were elevated to 10.14 ng/mL and 571 ng/mL (74.8 …
jp
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Accès ouvert
2026
article
OpenAlex
R. Yoshiyuki Osamura, Chie Inomoto, Shigeyuki Tahara, Kenichi Oyama et autres
This review is aimed at clarifying the background and the meaning of new terminology "pituitary neuroendocrine tumours" (PitNETs) in WHO Classification 2022. The PitNETs share the unique structures of secretory granules (SG) with other neuroendocrine tumors, the good example of which is …
jp
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Accès ouvert
2025
article
OpenAlex
Yohei Nounaka, Fumihiro Matano, K Isayama, K. Tomiyama et autres
Acromegaly most commonly results from excess growth hormone (GH) produced by pituitary neuroendocrine tumors (PitNETs). Craniopharyngioma (CP) is an uncommon suprasellar tumor characterized by cystic change and calcification. The true coexistence of PitNET and CP is rare and poses diagnostic and operative …
jp
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2025
preprint
OpenAlex
Nao Nitta, Yuko Sugiyama, Takeaki Sugimura, Takahiko Ito et autres
ABSTRACT Cytopathology plays a central role in the early detection of cancers such as cervical, lung, and bladder cancer due to its speed, simplicity, and minimally invasive nature. However, its effectiveness is limited by variability in diagnostic accuracy stemming from subjective visual …
jp, pt
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Accès ouvert
2024
article
OpenAlex
S. Onish, Aki Takada‐Watanabe, R. Yoshiyuki Osamura, Takayuki Shiomi et autres
Key Clinical Message This case highlights the possibility of an insulinoma expressing an aberrant form of SSTRs resulting in a discrepancy between the preoperative octreotide assessment and postoperative SSTR expression. Abstract Insulinoma is a pancreatic disease that causes hyperinsulinemic hypoglycemia. The first‐line …
jp
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Accès ouvert
2024
article
OpenAlex
Josef Rüschoff, Alexander Penner, Ian O. Ellis, M. Elizabeth Hammond et autres
CONTEXT.—: Recently, a new type of antibody-drug conjugate, trastuzumab-deruxtecan (T-DXd), has been approved for the treatment of metastatic breast cancer with low level of human epidermal growth factor receptor 2 (HER2) gene expression. Thereby, eligibility relies on an accurate diagnosis of HER2-low …
gb, us, de, fr, es, it
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Accès ouvert
2024
article
OpenAlex
R. Yoshiyuki Osamura
It was a great honor for
jp
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Accès ouvert
2023
article
OpenAlex
Koji Suzuki, Shigeyuki Tahara, Yujiro Hattori, Shinichiro Teramoto et autres
Collision tumors involving the metastasis of malignant neoplasms to pituitary neuroendocrine tumors (PitNETs) are extremely rare. We herein report a case involving a patient with lung adenocarcinoma metastasis within a PitNET who exhibited relatively rapid progression of neurological symptoms. A 75-year-old man …
jp
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Accès ouvert
2023
article
OpenAlex
Ichiro Nakazato, Takayuki Shiomi, Kenichi Oyama, Akira Matsuno et autres
Current therapeutic modalities for pituitary neuroendocrine tumors (PitNETs) include medication, surgery, and radiotherapy. Some patients have tumors that are refractory to current modalities. Therefore, novel treatment options are needed for patients with intractable diseases. Consequently, we examined the pathological data of PitNETs …
jp
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Accès ouvert
2023
article
OpenAlex
Yu Hirokawa, Chie Inomoto, Kenichi Oyama, Shigeyuki Tahara et autres
Insulinoma-associated protein 1 (INSM1) is a representative diagnostic marker of neuroendocrine neoplasms (NENs); however, it has not yet been used to diagnose pituitary neuroendocrine tumors (PitNETs), according to the 2022 World Health Organization (WHO) classification of pituitary tumors. This study aimed to …
jp, us
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Accès ouvert
2023
conference-abstract
OpenAlex
R. Yoshiyuki Osamura
Abstract It has been well known that the terminology has been changed from pituitary adenoma(4th WHO) which means benign epithelial tumors to pituitary neuroendocrine tumor(5th WHO 2022). It is apparent that the anterior pituitary cells and derived tumors contain intracytoplasmic neurosecretory granules …
jp
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Accès ouvert
2023
article
OpenAlex
Shigeyuki Tahara, R. Yoshiyuki Osamura, Yujiro Hattori, Eitaro Ishisaka et autres
BACKGROUND: Some patients develop immunoglobulin G4 (IgG4)-related hypophysitis associated with systemic diseases. More than 30 cases of IgG4-related hypophysitis have been reported. However, biopsy has rarely been performed in these patients, and none have had an associated pituitary neuroendocrine tumor (PitNET). We …
jp
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