Accès ouvert
2026
article
OpenAlex
Taisei AOKI, Yohei Nounaka, Fumihiro Matano, K Isayama et autres
Chordoid glioma (CG) is an extremely rare low-grade tumor arising from the suprasellar region. Here, we report a case of CG complicated by an anterior communicating artery aneurysm in a 51-year-old man. The patient underwent a single-stage surgery combining endoscopic transsphenoidal surgery …
us, jp
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Accès ouvert
2026
conference-abstract
OpenAlex
Fumio Otsuka, Hidenori Fukuoka, Shigeyuki Tahara, Shingo Fujio et autres
Abstract Introduction Somapacitan is approved for the treatment of adult growth hormone (GH) deficiency (AGHD) yet real-world reports in this population remain limited. We report interim results from a post-marketing study of Japanese patients (pts) with AGHD treated with somapacitan. Methods Eligible …
jp, it, dk, us, se
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Accès ouvert
2026
article
OpenAlex
Tadashi Higuchi, Shinsuke Abe, Satsuki Imaoka, Taisei AOKI et autres
当施設で外視鏡導入後の髄内腫瘍30例（神経膠腫10例，転移性脳腫瘍17例，脳悪性リンパ腫3例）で5ALA・NBI・ICGの有用性を術者の目視で定性評価した．5ALAは悪性神経膠腫で強い蛍光を示し顕微鏡と同等，ICGは血流評価に有用．NBIはあまり有用性が得られなかったが，低悪性度神経膠腫の脳表観察において，正常脳実質との境界を診断するのに有用となる可能性が示唆された．転移性脳腫瘍において，白色光に比べNBIは腫瘍本体と周囲白質との識別に有用である可能性が示唆された．なお易出血性腫瘍ではNBIは出血により黒色となってしまい，識別は非常に困難であった．しかしながら脳腫瘍摘出術における新たな蛍光診断の方法として，NBIは新規の蛍光診断の方法になりうる可能性を秘めている．
jp, us
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Accès ouvert
2025
article
OpenAlex
Yukako Nakayama, Mayumi Ishikawa, Asako Watanabe, Yoshio Shima et autres
Osilodrostat is a novel treatment for adrenocorticotropin-dependent Cushing syndrome; however, its safety during pregnancy has not been reported. This case involves a patient with Cushing disease who became pregnant while on osilodrostat. She was diagnosed at 31 years of age and underwent …
jp
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Accès ouvert
2025
article
OpenAlex
Keiko Tomiyama, Izumi Fukuda, Mikiko Okazaki‐Hada, Shunsuke Kobayashi et autres
Abstract Disclosure: K. Tomiyama: None. I. Fukuda: None. M. Okazaki-Hada: None. S. Kobayashi: None. T. Nagamine: None. K. Inagaki: None. M. Nagao: None. S. Tahara: None. M. Iwabu: None. Background: Acromegaly is characterized by renal hypertrophy and glomerular hyperfiltration due to excess …
jp
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Accès ouvert
2025
article
OpenAlex
Yohei Nounaka, Fumihiro Matano, K Isayama, K. Tomiyama et autres
Acromegaly most commonly results from excess growth hormone (GH) produced by pituitary neuroendocrine tumors (PitNETs). Craniopharyngioma (CP) is an uncommon suprasellar tumor characterized by cystic change and calcification. The true coexistence of PitNET and CP is rare and poses diagnostic and operative …
jp
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Accès ouvert
2025
article
OpenAlex
Fumio Otsuka, Michael Højby Rasmussen, Takaaki Endo, Claus Sværke et autres
Introduction: Somapacitan is a long-acting growth hormone (GH) derivative approved for once-weekly treatment of adult GH deficiency (AGHD). This study aimed to evaluate the efficacy and safety of somapacitan and daily GH in Japanese individuals with AGHD. Methods: ), both administered subcutaneously. …
jp, dk, se
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2024
article
OpenAlex
Shinichiro Teramoto, Shigeyuki Tahara, Hiromasa Goto, Takuma Kodama et autres
OBJECTIVE: Patients with sellar lesions compressing the optic nerve sometimes perceive visual improvement after lesion resection, despite the absence of visual impairment on preoperative ophthalmological examination. This study investigated the indicators of latent visual impairment in patients with sellar lesions. METHODS: Forty-five …
jp
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Accès ouvert
2024
article
OpenAlex
Fumihiro Matano, Shigeyuki Tahara, Yujiro Hattori, Yohei Nounaka et autres
Background: Fat is commonly used for preventing cerebrospinal fluid (CSF) leakage during endoscopic transsphenoidal surgery (ETSS). However, fat is soft, slippery, and sometimes not easy to handle. The present study aimed to examine the efficacy of our Surgicel® wrapping method, which allows …
jp
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2024
article
OpenAlex
Yujiro Hattori, Shigeyuki Tahara, Hitoshi Ozawa, Akio Morita et autres
INTRODUCTION: Lactotroph pituitary neuroendocrine tumors (PitNETs) are common pituitary tumors, but their underlying molecular mechanisms remain unclear. This study aimed to investigate the transcriptomic landscape of lactotroph PitNETs and identify potential molecular mechanisms and therapeutic targets through RNA sequencing and ingenuity pathway …
jp
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Accès ouvert
2023
article
OpenAlex
Koji Suzuki, Shigeyuki Tahara, Yujiro Hattori, Shinichiro Teramoto et autres
Collision tumors involving the metastasis of malignant neoplasms to pituitary neuroendocrine tumors (PitNETs) are extremely rare. We herein report a case involving a patient with lung adenocarcinoma metastasis within a PitNET who exhibited relatively rapid progression of neurological symptoms. A 75-year-old man …
jp
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Accès ouvert
2023
article
OpenAlex
Yu Hirokawa, Chie Inomoto, Kenichi Oyama, Shigeyuki Tahara et autres
Insulinoma-associated protein 1 (INSM1) is a representative diagnostic marker of neuroendocrine neoplasms (NENs); however, it has not yet been used to diagnose pituitary neuroendocrine tumors (PitNETs), according to the 2022 World Health Organization (WHO) classification of pituitary tumors. This study aimed to …
jp, us
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