M. Elizabeth Hammond

Paxbp1 restrains cytotoxic and innate cell programs in CD4+ T cells to promote Th2 differentiation

Danielle A. Chisolm, Yuki Morimoto, Hiroyuki Nagashima, Stephen R. Brooks et autres

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Zebrafish Kelch-like family member 4 is required for vasculogenesis and hematopoiesis

Kaitlin Ferrari, Suman Gurung, Luiza N. Loges, Surya Prakash Rao Batta et autres

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Global Study on the Accuracy of Human Epidermal Growth Factor Receptor 2-Low Diagnosis in Breast Cancer

Josef Rüschoff, Alexander Penner, Ian O. Ellis, M. Elizabeth Hammond et autres

CONTEXT.—: Recently, a new type of antibody-drug conjugate, trastuzumab-deruxtecan (T-DXd), has been approved for the treatment of metastatic breast cancer with low level of human epidermal growth factor receptor 2 (HER2) gene expression. Thereby, eligibility relies on an accurate diagnosis of HER2-low …

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Data from The Importance of Protein Kinase A in Prostate Cancer: Relationship to Patient Outcome in Radiation Therapy Oncology Group Trial 92-02

Alan Pollack, Kyounghwa Bae, Li-Yan Khor, Tahseen Al‐Saleem et autres

Abstract Purpose: We previously reported that protein kinase A type I (PKARIα) overexpression was predictive of outcome in prostate cancer patients treated with radiotherapy (RT) ± short-term androgen deprivation (STAD) on Radiation Therapy Oncology Group (RTOG) protocol 86-10. Here, we attempt to …

Data from The Importance of Protein Kinase A in Prostate Cancer: Relationship to Patient Outcome in Radiation Therapy Oncology Group Trial 92-02

Alan Pollack, Kyounghwa Bae, Li-Yan Khor, Tahseen Al‐Saleem et autres

Abstract Purpose: We previously reported that protein kinase A type I (PKARIα) overexpression was predictive of outcome in prostate cancer patients treated with radiotherapy (RT) ± short-term androgen deprivation (STAD) on Radiation Therapy Oncology Group (RTOG) protocol 86-10. Here, we attempt to …

Supplementary Data from The Importance of Protein Kinase A in Prostate Cancer: Relationship to Patient Outcome in Radiation Therapy Oncology Group Trial 92-02

Alan Pollack, Kyounghwa Bae, Li-Yan Khor, Tahseen Al‐Saleem et autres

Supplementary Data from The Importance of Protein Kinase A in Prostate Cancer: Relationship to Patient Outcome in Radiation Therapy Oncology Group Trial 92-02

An Overview of Clinical Development of Agents for Metastatic or Advanced Breast Cancer Without ERBB2 Amplification (HER2-Low)

Aleix Prat, Aditya Bardia, Giuseppe Curigliano, M. Elizabeth Hammond et autres

Importance: Erb-b2 receptor tyrosine kinase 2 (ERBB2; formerly HER2 [human epidermal growth factor receptor 2]) is an important prognostic and predictive factor in breast cancer. Anti-ERBB2 therapies have improved outcomes in ERBB2-positive breast cancer. However, based on current definitions, tumors with low …

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Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: ASCO Clinical Practice Guideline Update—Integration of Results From TAILORx

Fabrice André, Nofisat Ismaila, N. Lynn Henry, Mark R. Somerfield et autres

PURPOSE This focused update addresses the use of Onco type DX in guiding decisions on the use of adjuvant systemic therapy. METHODS ASCO uses a signals approach to facilitate guideline updating. For this focused update, the publication of the Trial Assigning Individualized …

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In Reply

Antonio C. Wolff, M. Elizabeth Hammond, Kimberly H. Allison, Brittany Harvey et autres

In Reply.—Murray et al1 and Martin et al2 shared their experiences with the 2018 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) human epidermal growth factor receptor 2 (HER2) testing in breast cancer focused update3,4 and compared the new recommendations …

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Reply to C. Murray et al and V. Martin et al

Antonio C. Wolff, M. Elizabeth Hammond, Kimberly H. Allison, Brittany Harvey et autres

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HER2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update Summary

Antonio C. Wolff, M. Elizabeth Hammond, Kimberly H. Allison, Brittany Harvey et autres

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Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update

Antonio C. Wolff, M. Elizabeth Hammond, Kimberly H. Allison, Brittany Harvey et autres

PURPOSE.—: To update key recommendations of the American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) human epidermal growth factor receptor 2 (HER2) testing in breast cancer guideline. METHODS.—: Based on the signals approach, an Expert Panel reviewed published literature and …

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