Mercedes González Moreno

Phage-liposome nanoconjugates for orthopedic biofilm eradication

Lei Wang, Tamta Tkhilaishvili, Zheng Jiang, Rima Fanaei Pirlar et autres

Infection by multidrug-resistant (MDR) bacteria has become one of the biggest threats to public health worldwide. One reason for the difficulty in treatment is the lack of proper delivery strategies into MDR bacterial biofilms, where the thick extracellular polymeric substance (EPS) layer …

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Targeting Pseudomonas aeruginosa biofilm with an evolutionary trained bacteriophage cocktail exploiting phage resistance trade-offs

Fabian Kunisch, Claudia Campobasso, Jeroen Wagemans, Selma Yıldırım et autres

Spread of multidrug-resistant Pseudomonas aeruginosa strains threatens to render currently available antibiotics obsolete, with limited prospects for the development of new antibiotics. Lytic bacteriophages, the viruses of bacteria, represent a path to combat this threat. In vitro-directed evolution is traditionally applied to …

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Combination of bacteriophages and vancomycin in a co-delivery hydrogel for localized treatment of fracture-related infections

Baixing Chen, Luis Ponce Benavente, Marco Chittò, Virginia Post et autres

Fracture-related infections (FRIs), particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA), are challenging to treat. This study designed and evaluated a hydrogel loaded with a cocktail of bacteriophages and vancomycin (1.2 mg/mL). The co-delivery hydrogel showed 99.72% reduction in MRSA biofilm in …

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In vitro evaluation of microbial D- and L-lactate production as biomarkers of infection

Paula Morovic, Mercedes González Moreno, Andrej Trampuž, Svetlana Karbysheva

Mammalian cells produce and metabolize almost exclusively L-lactate, bacterial species have the capacity to produce both D-lactate and L-lactate. The aim of this study was to evaluate the intrinsic production of D- and L-lactate in the most common pathogenic microorganisms causing septic …

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Targeted enhancement of bacteriophage activity against antibiotic-resistant Staphylococcus aureus biofilms through an evolutionary assay

Luis Ponce Benavente, Jeroen Wagemans, Dennis Hinkel, Alba Aguerri Lajusticia et autres

Staphylococcus aureus ´ biofilm-forming ability and rapid resistance development pose a significant challenge to successful treatment, particularly in postoperative complications, emphasizing the need for enhanced therapeutic strategies. Bacteriophage (phage) therapy has reemerged as a promising and safe option to combat multidrug-resistant bacteria. …

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Efficacy of different bioactive glass S53P4 formulations in biofilm eradication and the impact of pH and osmotic pressure

Nele Müller, Matthias R. Kollert, Andrej Trampuž, Mercedes González Moreno

AIM: The challenging properties of biofilm-associated infections and the rise of multidrug-resistant bacteria are prompting the exploration of alternative treatment options. This study investigates the efficacy of different bioactive glass (BAG) formulations - alone or combined with vancomycin - to eradicate biofilm. …

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Addressing the Research and Development Gaps in Modern Phage Therapy

Paul E. Turner, Joana Azeredo, Ed T. Buurman, Sabrina I. Green et autres

Antimicrobial resistance is on the rise globally, prompting increased research and development (R&D) of phage therapy as a strategy to address difficult-to-treat bacterial infections. We review the current state of phage therapy research, including major operational, epistemic, and biological challenges for phage …

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SYNERGISTIC ACTION OF BACTERIOPHAGE AND VANCOMYCIN IN A CO-DELIVERY HYDROGEL FOR LOCALIZED TREATMENT OF FRACTURE-RELATED INFECTION CAUSED BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS

Baixing Chen, Marco Chittò, Luis Ponce Benavente, Virginia Post et autres

Aim Bacteriophages are remerging as alternative and adjunctive therapy for fracture-related infection (FRI). However, current administration protocols involve prolonged retention of a percutaneous draining tube with potential risk of developing superinfection. In this study, we applied a cocktail of in vitro evolved …

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Alginate microbeads and hydrogels delivering meropenem and bacteriophages to treat Pseudomonas aeruginosa fracture-related infections

Baixing Chen, Luis Ponce Benavente, Marco Chittò, Jacek K. Wychowaniec et autres

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Targeting MDR Pseudomonas aeruginosa biofilm with an evolutionary trained bacteriophage cocktail exploiting phage resistance trade-offs

Fabian Kunisch, Jeroen Wagemans, Selma Yıldırım, Benjamin K. Chan et autres

Abstract Spread of multidrug-resistant Pseudomonas aeruginosa strains threatens to render currently available antibiotics obsolete, with limited prospects for the development of new antibiotics. Lytic bacteriophages (phages), the natural predators of bacteria, represent a path to combat this threat. In vitro directed evolution …

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Bacteriophage Liquid Propagation in Pseudomonas aeruginosa

Fabian Kunisch, Mercedes González Moreno

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Bacteriophage DNA Organic Extraction

Fabian Kunisch, Jeroen Wagemans, Mercedes González Moreno

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