Lisa Schnell

Low serum testosterone levels in male psoriasis patients correlate with disease severity

Jean‐Pierre Allam, Chris Bunzek, Lisa Schnell, Max Heltzel et autres

Psoriasis is a chronic inflammatory skin disease with a genetic and autoimmune background. The involvement of sex hormones as a trigger factor for psoriasis has been suspected. Recently, low serum testosterone has been associated with autoimmune diseases in males, and the role …

de (code pays fourni par la source)

Where Does It Come From

Lisa Schnell

What is a Season

Lisa Schnell

Successful treatment with interleukin‐17A antagonists of generalized pustular psoriasis in patients without IL36RN mutations

Dagmar Wilsmann‐Theis, Lisa Schnell, Veronika Ralser‐Isselstein, Thomas R.M. Bieber et autres

Generalized pustular psoriasis (GPP) is a potentially life-threatening disease that can be attributed to mutations in IL36RN in a subgroup of patients. In small trials, interleukin (IL)-17A and IL-17RA antagonists have been shown to be effective in patients with generalized pustular psoriasis …

de (code pays fourni par la source)

Direct, long-term intrathecal application of therapeutics to the rodent CNS

Benjamin Victor Ineichen, Lisa Schnell, Miriam Gullo, Julia Kaiser et autres

ch, de (code pays fourni par la source)

Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury

Thomas Broggini, Lisa Schnell, Ali Ghoochani, José Marı́a Mateos et autres

The Plasticity Related Gene family covers five, brain-specific, transmembrane proteins (PRG1-5, also termed LPPR1-5) that operate in neuronal plasticity during development, aging and brain trauma. Here we investigated the role of the PRG family on axonal and filopodia outgrowth. Comparative analysis revealed …

us, de, ch (code pays fourni par la source)

The Schnell Swim Test (SST) to measure motor function and recovery in spinal cord injured rats

Mirjam Gullo, Eva Hochreutener, Dina Schnell, Jeannette Scholl et autres

Impaired functions in spinal cord lesioned rodents can be measured by a variety of different behavioral tests which range from elementary locomotor analysis to more demanding assays to analyze motor as well as sensory functions [1, 2, 3, 4, 5, 6]. Some …

ch (code pays fourni par la source)

Combination treatment with anti‐Nogo‐A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury

Rongrong Zhao, Melissa R. Andrews, Difei Wang, Philippa Mary Warren et autres

Anti-Nogo-A antibody and chondroitinase ABC (ChABC) enzyme are two promising treatments that promote functional recovery after spinal cord injury (SCI). Treatment with them has encouraged axon regeneration, sprouting and functional recovery in a variety of spinal cord and central nervous system injury …

gb, ch (code pays fourni par la source)

Neutralization of Inhibitory Molecule NG2 Improves Synaptic Transmission, Retrograde Transport, and Locomotor Function after Spinal Cord Injury in Adult Rats

Hayk A. Petrosyan, Arsen S. Hunanyan, Valentina Alessi, Lisa Schnell et autres

NG2 belongs to the family of chondroitin sulfate proteoglycans that are upregulated after spinal cord injury (SCI) and are major inhibitory factors restricting the growth of fibers after SCI. Neutralization of NG2's inhibitory effect on axon growth by anti-NG2 monoclonal antibodies (NG2-Ab) …

us (code pays fourni par la source)

Chondroitinase ABC Combined with Neurotrophin NT-3 Secretion and NR2D Expression Promotes Axonal Plasticity and Functional Recovery in Rats with Lateral Hemisection of the Spinal Cord

Guillermo García‐Alías, Hayk A. Petrosyan, Lisa Schnell, Philip J. Horner et autres

Elevating spinal levels of neurotrophin NT-3 (NT3) while increasing expression of the NR2D subunit of the NMDA receptor using a HSV viral construct promotes formation of novel multisynaptic projections from lateral white matter (LWM) axons to motoneurons in neonates. However, this treatment …

gb, us, ch, pt (code pays fourni par la source)

Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional ‘detour’ in the hemisected spinal cord

Lisa Schnell, Arsen S. Hunanyan, William J. Bowers, Philip J. Horner et autres

To encourage re-establishment of functional innervation of ipsilateral lumbar motoneurons by descending fibers after an intervening lateral thoracic (T10) hemisection (Hx), we treated adult rats with the following agents: (i) anti-Nogo-A antibodies to neutralize the growth-inhibitor Nogo-A; (ii) neurotrophin-3 (NT-3) via engineered …

us (code pays fourni par la source)

Delayed Anti-Nogo-A Antibody Application after Spinal Cord Injury Shows Progressive Loss of Responsiveness

Roman Rudolf Gonzenbach, Bjoern Zoerner, Lisa Schnell, Oliver Weinmann et autres

Blocking the function of the myelin protein Nogo-A or its signaling pathway is a promising method to overcome an important neurite growth inhibitory factor of the adult central nervous system (CNS), and to enhance axonal regeneration and plasticity after brain or spinal …

ch, nl (code pays fourni par la source)