Julia Kaiser

Developmental molecular signatures define de novo cortico-brainstem circuit for skilled forelimb movement

Julia Kaiser, Payal Patel, Sam Fedde, Alexander Lammers et autres

Skilled movement relies on descending cortical projections to the brainstem and spinal cord. The brainstem integrates cortical inputs from subcerebral projection neurons (SCPN). Here, we identify a previously unrecognized direct cortico-brainstem circuit that emerges early in development and persists into adulthood. A …

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Selective Targeting of a Defined Subpopulation of Corticospinal Neurons Using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity

Julia Kaiser, Payal Patel, Aidan Raghu, James Conner et autres

The corticospinal tract (CST) facilitates skilled, precise movements, which necessitates that subcerebral projection neurons (SCPNs) establish segmentally specific connectivity with brainstem and spinal circuits. Developmental molecular delineation enables prospective identification of corticospinal neurons (CSNs) projecting to thoraco-lumbar spinal segments; however, it remains …

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Developmental molecular signatures define de novo cortico-brainstem circuit for skilled forelimb movement

Vibhu Sahni, Julia Kaiser, Payal Patel, Svenja Fedde et autres

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Selective Targeting of a Defined Subpopulation of Corticospinal Neurons using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity

Julia Kaiser, Payal Patel, Aidan Raghu, James Conner et autres

The corticospinal tract (CST) facilitates skilled, precise movements, which necessitates that subcerebral projection neurons (SCPN) establish segmentally specific connectivity with brainstem and spinal circuits. Developmental molecular delineation enables prospective identification of corticospinal neurons (CSN) projecting to thoraco-lumbar spinal segments; however, it remains …

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STARQ: Domain-Invariant Brainstem Nuclei Segmentation and Signal Quantification

Julia Kaiser, Dana Luong, Eunseo Sung, Asim Iqbal et autres

A bstract Brainstem nuclei are hard to distinguish due to very few distinctive features which makes detecting them with high accuracy extremely difficult. We introduce StARQ that builds on SeBRe, a deep learning-based framework to segment regions of interest. StARQ provides new …

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Deep learning-based behavioral profiling of rodent stroke recovery

R. Weber, Geertje Mulders, Julia Kaiser, Christian Tackenberg et autres

BACKGROUND: Stroke research heavily relies on rodent behavior when assessing underlying disease mechanisms and treatment efficacy. Although functional motor recovery is considered the primary targeted outcome, tests in rodents are still poorly reproducible and often unsuitable for unraveling the complex behavior after …

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Molecular specification of cortico-brainstem versus corticospinal projection neurons in development

Julia Kaiser, Payal Patel, Friederike Dündar, Jimena Perez-Tetuan et autres

Abstract Skilled motor control requires precise connections between subcerebral projection neurons (SCPN) in the cerebral cortex and their appropriate subcerebral targets in the brainstem or spinal cord. The brainstem is an important motor control center and cortical projections to the brainstem serve …

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Revisiting Long-Distance Axon Growth Ability in the Developing Spinal Cord using a Novel Lesion Paradigm

Carolin Ruven, Julia Kaiser, Payal Patel, Francesca Serraino et autres

Established experimental lesions in the developing central nervous system (CNS) disrupt microenvironments critical for long-distance axon growth and guidance. Therefore, the precise developmental time at which the CNS ceases its capacity to support long-distance axon growth remains unknown. Accordingly, we established a …

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Intention Ascriptions as a Means to Coordinate Own Actions with Others’ Actions

Arnulf Deppermann, Julia Kaiser

While the role of intentions in the constitution of actions gives rise to complex and heavily controversial questions, it appears to be indisputable that action ascription in interaction mostly does without any overt ascription of intention. Yet, sometimes participants explicitly ascribe intentions …

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ZuMult: Neue Zugangswege zu Korpora gesprochener Sprache

Christian Fandrych, Elena Frick, Julia Kaiser, Cordula Meißner et autres

ZuMult ("Zugänge zu multimodalen Korpora gesprochener Sprache -Vernetzung und zielgruppenspezifische Ausdifferenzierung") ist ein Kooperationsprojekt zwischen drei Partnern mit großen Sammlungen mündlicher Korpora der deutschen Sprache: dem Archiv für gesprochenes Deutsch (AGD) am IDS Mannheim, dem Hamburger Zentrum für Sprachkorpora (HZSK) an der …

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Alltags|Mathe|real – Digitale Entdeckerfelder für die Förderung mathematisch begabter vier- bis zehnjähriger Kinder

Julia Kaiser, Franziska Strübbe, Alena Witte

The development of alternative sustainable concepts for the support of mathematically gifted children at a distance is currently frequently discussed. Educational professionals in kindergartens and schools are faced with the challenge of always reacting adaptively to the respective situation resulting from global …

Deep learning based behavioral profiling of rodent stroke recovery

R. Weber, Geertje Mulders, Julia Kaiser, Christian Tackenberg et autres

Abstract Stroke research heavily relies on rodent behavior when assessing underlying disease mechanisms and treatment efficacy. Although functional motor recovery is considered the primary targeted outcome, tests in rodents are still poorly reproducible, and often unsuitable for unraveling the complex behavior after …

ch, us (code pays fourni par la source)