Philippa Mary Warren

Recovery of Forearm and Fine Digit Function After Chronic Spinal Cord Injury by Simultaneous Blockade of Inhibitory Matrix Chondroitin Sulfate Proteoglycan Production and the Receptor PTPσ

Adrianna J. Milton, Jessica C. F. Kwok, Jacob McClellan, Sabre Randall et autres

Spinal cord injuries (SCI), for which there are limited effective treatments, result in enduring paralysis and hypoesthesia, in part because of the inhibitory microenvironment that develops and limits regeneration/sprouting, especially during chronic stages. Recently, we discovered that targeted enzymatic removal of the …

us, gb, cz (code pays fourni par la source)

Editorial: Fighting for recovery on multiple fronts in spinal cord injury

Jacob Kjell, Jennifer N. Dulin, Philippa Mary Warren

EDITORIAL article Front. Cell. Neurosci., 14 March 2023Sec. Cellular Neuropathology Volume 17 - 2023 | https://doi.org/10.3389/fncel.2023.1178192

se, us, gb (code pays fourni par la source)

Delayed viral vector mediated delivery of neurotrophin-3 improves skilled hindlimb function and stability after thoracic contusion

Jared D. Sydney-Smith, Alice M. Koltchev, Lawrence David Falcon Moon, Philippa Mary Warren

Intramuscular injection of an Adeno-associated viral vector serotype 1 (AAV1) encoding Neurotrophin-3 (NT3) into hindlimb muscles 24 h after a severe T9 spinal level contusion in rats has been shown to induce lumbar spinal neuroplasticity, partially restore locomotive function and reduce spasms …

gb (code pays fourni par la source)

Recovery of forearm and fine digit function after chronic spinal cord injury by simultaneous blockade of inhibitory matrix CSPG production and the receptor PTPσ

Adrianna J. Milton, Daniel J. Silver, Jessica C. F. Kwok, Jacob McClellan et autres

Abstract Spinal cord injuries, for which there are limited effective clinical treatments, result in enduring paralysis and hypoesthesia due, in part, to the inhibitory microenvironment that develops and limits regeneration/sprouting, especially during chronic stages. Recently, we discovered that targeted enzymatic modulation of …

us, gb (code pays fourni par la source)

Delayed viral vector mediated delivery of neurotrophin-3 improves skilled hindlimb function and stability after thoracic contusion in rats

Jared D. Sydney-Smith, Alice M. Koltchev, Lawrence David Falcon Moon, Philippa Mary Warren

Abstract It has been reported that intramuscular injection of an Adeno-associated viral vector serotype 1 (AAV1) encoding Neurotrophin-3 (NT3) into hindlimb muscles 24 hours after a severe T9 contusion in rats induced lumbar spinal neuroplasticity, partially restored locomotive function and reduced spasms …

gb, us (code pays fourni par la source)

Peripherally delivered Adeno-associated viral vectors for spinal cord injury repair

Jared D. Sydney-Smith, Aline Barroso Spejo, Philippa Mary Warren, Lawrence David Falcon Moon

gb (code pays fourni par la source)

New insights into glial scar formation after spinal cord injury

Amanda Phuong Tran, Philippa Mary Warren, Jerry Silver

Severe spinal cord injury causes permanent loss of function and sensation throughout the body. The trauma causes a multifaceted torrent of pathophysiological processes which ultimately act to form a complex structure, permanently remodeling the cellular architecture and extracellular matrix. This structure is …

us, gb (code pays fourni par la source)

Substrate Specificity and Biochemical Characteristics of an Engineered Mammalian Chondroitinase ABC.

Philippa Mary Warren, James W. Fawcett, Jessica C. F. Kwok

Chondroitin sulfate proteoglycans inhibit regeneration, neuroprotection, and plasticity following spinal cord injury. The development of a second-generation chondroitinase ABC enzyme, capable of being secreted from mammalian cells (mChABC), has facilitated the functional recovery of animals following severe spinal trauma. The genetically modified …

Substrate Specificity and Biochemical Characteristics of an Engineered Mammalian Chondroitinase ABC

Philippa Mary Warren, James W. Fawcett, Jessica C. F. Kwok

Chondroitin sulfate proteoglycans inhibit regeneration, neuroprotection, and plasticity following spinal cord injury. The development of a second-generation chondroitinase ABC enzyme, capable of being secreted from mammalian cells (mChABC), has facilitated the functional recovery of animals following severe spinal trauma. The genetically modified …

gb, cz (code pays fourni par la source)

Oxygen transport kinetics underpin rapid and robust diaphragm recovery following chronic spinal cord injury

Philippa Mary Warren, Roger W. P. Kissane, Stuart Egginton, Jessica C. F. Kwok et autres

KEY POINTS: Spinal treatment can restore diaphragm function in all animals 1 month following C2 hemisection induced paralysis. Greater recovery occurs the longer after injury the treatment is applied. Through advanced assessment of muscle mechanics, innovative histology and oxygen tension modelling, we …

gb, cz (code pays fourni par la source)

Secretion of a mammalian chondroitinase ABC aids glial integration at PNS/CNS boundaries

Philippa Mary Warren, Melissa R. Andrews, M.E. Smith, Katalin Bartus et autres

Schwann cell grafts support axonal growth following spinal cord injury, but a boundary forms between the implanted cells and host astrocytes. Axons are reluctant to exit the graft tissue in large part due to the surrounding inhibitory environment containing chondroitin sulphate proteoglycans …

gb, nl, cz (code pays fourni par la source)

Regulation of autophagy by inhibitory CSPG interactions with receptor PTPσ and its impact on plasticity and regeneration after spinal cord injury

Amanda Phuong Tran, Philippa Mary Warren, Jerry Silver

us, gb (code pays fourni par la source)