Subo Yuan

Illuminating ongoing pain in mice with novel bioluminescent imaging

Subo Yuan, Jia Yi Liew, Ajay Pal, Jigong Wang et autres

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Identification of a reactive astrocyte subpopulation during HIV-associated pain pathogenesis in mouse models

Junying Zheng, Michael S. Spurgat, Zachary L. Watson, Sakib Hossain et autres

Pain is a common complication in individuals with HIV, yet the underlying pathogenic mechanisms remain poorly understood. Reactive astrocytes are selectively activated in the spinal dorsal horn of HIV patients experiencing pathological pain, implicating their potential role in pain pathogenesis. However, the …

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HIV-associated sensory neuropathy: current progress and future challenges

Isaac J. Gamez, Ajay Kumar Pal, Subo Yuan

Currently, no US Food and Drug Administration-approved treatments exist to manage HIV-associated sensory neuropathy (HIV-SN) and management is largely confined to adjusting antiretroviral therapy (ART) doses and medications. Thus, this urgent health crisis requires strong research commitment to identify a cure or …

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Differential selectivity of microglia and astrocytes in HIV-1 gp120-induced synaptic pruning

Silvana Valdebenito-Silva, Michael S. Spurgat, Wenjuan Ru, Junying Zheng et autres

Synapse loss is a common neuropathology in the CNS of HIV patients, likely contributing to neurological complications such as neurocognitive disorders and pain. However, the underlying mechanism remains poorly understood. Here, we show microglia- and astrocyte-mediated synaptic pruning of excitatory and inhibitory …

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Sensory Deficits in Mice with Lateral Spinal Cord Hemisection Mimic the Brown–Séquard Syndrome

Melissa K. Henwood, Junkui Shang, Qiang Li, John Moth et autres

Spinal cord injury (SCI) often results in permanent sensory deficits, significantly impairing the quality of life. These deficits are poorly addressed due to a lack of valid animal models with translational relevance. Here, we utilized a thoracic Level 8 lateral hemisection SCI …

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Huntingtin preserves mitochondrial genome integrity in neurons, which is impaired in Huntington’s disease

Subrata Pradhan, Sagar Gaikwad, Chi-Lin Tsai, Charlene Smith et autres

SUMMARY Huntingtin (HTT) function is enigmatic, as the native protein plays critical roles in neuronal health, while mutant HTT (mHTT), carrying an expanded polyglutamine stretch, triggers neurotoxicity and contributes to the pathogenesis of Huntington’s disease (HD). We recently found that HTT is …

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Sensory neuron–expressed FGF13 controls nociceptive signaling in diabetic neuropathy models

Aditya Kumar Singh, Matteo Bernabucci, Nolan Michael Dvorak, Zahra Haghighijoo et autres

Nociception involves complex signaling, yet intrinsic mechanisms bidirectionally regulating this process remain unexplored. Here, we show that the fibroblast growth factor 13 (FGF13)/Nav1.7 protein-protein interaction (PPI) complex bidirectionally modulates nociception, and that the FGF13/Nav1.7 ratio is upregulated in type 2 diabetic neuropathy …

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Development of noninvasive imaging to measure spontaneous pain in mice

Subo Yuan, Jia Yi Liew, Ajay Pal, Jigong Wang et autres

Objectively measuring pain in laboratory animals is essential for pain research and analgesic development. Despite the development of various behavioral tests to measure evoked pain in animal models, measuring spontaneous pain remains challenging. To address this unmet need, we developed a novel …

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Circulating extracellular vesicles from HIV-1 gp120-treated mice act as endogenous algogens, mediating and maintaining HIV-associated chronic pain

Subo Yuan, Jia Yi Liew, Jiani Bei, Ajay Kumar Pal et autres

Abstract HIV-associated chronic pain (HIV-PAIN) remains prevalent in the post combined antiretroviral therapy era, affecting 30-60% of HIV patients worldwide. The underlying mechanism responsible for the development and maintenance of chronic pain remains unclear. gp120 is a causal factor of the HIV-PAIN …

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Chromatin remodeler BRG1 recruits huntingtin to repair DNA double-strand breaks in neurons

Subrata Pradhan, Keegan M. Bush, Nan Zhang, RAJ KUMAR PANDITA et autres

SUMMARY Persistent DNA double-strand breaks (DSBs) are enigmatically implicated in neurodegenerative diseases including Huntington’s disease (HD), the inherited late-onset disorder caused by CAG repeat elongations in Huntingtin (HTT). Here we combine biochemistry, computation and molecular cell biology to unveil a mechanism whereby …

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Circulating Exosomes from Alzheimer’s Disease Suppress Vascular Endothelial-Cadherin Expression and Induce Barrier Dysfunction in Recipient Brain Microvascular Endothelial Cell

Jiani Bei, Ernesto G. Miranda-Morales, Qini Gan, Yuan Qiu et autres

BACKGROUND: Blood-brain barrier (BBB) breakdown is a crucial aspect of Alzheimer's disease (AD) progression. Dysfunction in BBB is primarily caused by impaired tight junction and adherens junction proteins in brain microvascular endothelial cells (BMECs). The role of adherens junctions in AD-related BBB …

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Identification of a novel subtype of astrocytes in HIV-associated pain pathogenesis

Shao‐Jun Tang, Junying Zheng, Michael S. Spurgat, Subo Yuan et autres

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