Wenjuan Ru

Differential selectivity of microglia and astrocytes in HIV-1 gp120-induced synaptic pruning

Silvana Valdebenito-Silva, Michael S. Spurgat, Wenjuan Ru, Junying Zheng et autres

Synapse loss is a common neuropathology in the CNS of HIV patients, likely contributing to neurological complications such as neurocognitive disorders and pain. However, the underlying mechanism remains poorly understood. Here, we show microglia- and astrocyte-mediated synaptic pruning of excitatory and inhibitory …

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SP1 regulates BMSC osteogenic differentiation through the miR-133a-3p/MAPK3 axis

Liying Zhong, Yehai Sun, Cong Wang, Runzhi Liu et autres

BACKGROUND: The progression of osteoporosis (OP) can dramatically increase the risk of fractures, which seriously disturb the life of elderly individuals. Specific protein 1 (SP1) is involved in OP progression. However, the mechanism by which SP1 regulates OP progression remains unclear. OBJECTIVE: …

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Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway

Zuliang Jie, Chun‐Jung Ko, Hui Wang, Xiaoping Xie et autres

Microglia have been implicated in neuroinflammatory diseases, including multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). We demonstrate that microglia mediate EAE disease progression via a mechanism relying on the noncanonical nuclear factor kB (NF-κB) pathway. Microglia-specific deletion of the …

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Single-cell RNA-seq analysis reveals compartment-specific heterogeneity and plasticity of microglia

Junying Zheng, Wenjuan Ru, Jay R T. Adolacion, Michael S. Spurgat et autres

Microglia are ubiquitous central nervous system (CNS)-resident macrophages that maintain homeostasis of neural tissues and protect them from pathogen attacks. Yet, their differentiation in different compartments remains elusive. We performed single-cell RNA-seq to compare microglial subtypes in the cortex and the spinal …

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IL-22 hinders antiviral T cell responses and exacerbates ZIKV encephalitis in immunocompetent neonatal mice

Yuejin Liang, Panpan Yi, Wenjuan Ru, Zuliang Jie et autres

Abstract Background The Zika virus (ZIKV) outbreak that occurred in multiple countries was linked to increased risk of nervous system injuries and congenital defects. However, host immunity- and immune-mediated pathogenesis in ZIKV infection are not well understood. Interleukin-22 (IL-22) is a crucial …

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IL-22 hinders antiviral T cell responses and exacerbates neurological disorders in ZIKV-infected immunocompetent neonatal mice

Yuejin Liang, Panpan Yi, Wenjuan Ru, Zuliang Jie et autres

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A multistep deep learning framework for the automated detection and segmentation of astrocytes in fluorescent images of brain tissue

Cihan Bilge Kayasandık, Wenjuan Ru, Demetrio Labate

While astrocytes have been traditionally described as passive supportive cells, studies during the last decade have shown they are active players in many aspects of CNS physiology and function both in normal and disease states. However, the precise mechanisms regulating astrocytes function …

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Single cell RNA-seq analysis reveals compartment-specific heterogeneity and plasticity of microglia

Junying Zheng, Wenjuan Ru, Jay R T. Adolacion, Michael S. Spurgat et autres

Abstract Microglia are heterogeneous and ubiquitous CNS-resident macrophages that maintain homeostasis of neural tissues and protect them from pathogen attacks. Yet, their differentiation in different compartments remains elusive. We performed single cell RNA-seq (scRNA-seq) analysis to compare the transcriptomes of microglia in …

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Single Cell RNA-Seq Analysis Reveals Compartment-Specific Heterogeneity and Plasticity of Microglia

Junying Zheng, Wenjuan Ru, Jay R T. Adolacion, Michael S. Spurgat et autres

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Microglia Mediate HIV-1 gp120-Induced Synaptic Degeneration in Spinal Pain Neural Circuits

Wenjuan Ru, Xin Liu, Chilman Bae, Yuqiang Shi et autres

HIV-1 infection of the nervous system causes various neurological diseases, and synaptic degeneration is likely a critical step in the neuropathogenesis. Our prior studies revealed a significant decrease of synaptic protein, specifically in the spinal dorsal horn of patients with HIV-1 in …

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Glia-mediated mechanisms of HIV-1-gp120-induced Synaptic Degeneration

Wenjuan Ru

Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection

Huanle Luo, E. Winkelmann, Shuang Zhu, Wenjuan Ru et autres

The E3 ubiquitin ligase Pellino 1 (Peli1) is a microglia-specific mediator of autoimmune encephalomyelitis. Its role in neurotropic flavivirus infection is largely unknown. Here, we report that mice deficient in Peli1 (Peli1-/-) were more resistant to lethal West Nile virus (WNV) infection …

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