Tomoya Onozato

Combined effect of lipoprotein(a) and C-reactive protein on future cardiovascular outcomes after acute myocardial infarction

Shigeki Inaba, H Wada, Mihoko Ogita, Aki Yamada et autres

Abstract Background Both lipoprotein(a) (Lp[a]) and C-reactive protein (CRP) have been reported as risk factors of cardiovascular events in patients with coronary artery disease. Purpose The aim of the present study is to evaluate the impact of combined Lp(a) and CRP levels …

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Gender differences in long-term outcome of patients with cardiogenic shock complicating acute coronary syndrome

Takaaki Ajima, Manabu Ogita, Yuka Nobushima, Akira Yamada et autres

Abstract Introduction Cardiogenic shock (CS) remains the leading cause of death in patients with acute coronary syndrome (ACS). Women are at higher risk of mortality from ACS, and less likely to receive medical and invasive therapy including mechanical circulating support device. Previous …

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Impact of baseline and serial C-reactive protein on the future cardiovascular death in patients with acute myocardial infarction after percutaneous coronary intervention

Yuka Nobushima, Mihoko Ogita, Takaaki Ajima, Aki Yamada et autres

Abstract Introduction C-reactive protein (CRP) is an established inflammatory biomarker and associated with short-term adverse outcomes after acute myocardial infarction (AMI). It remains unclear whether baseline and serial CRP levels were associated with long term clinical outcomes in patients with AMI. Purpose …

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Spontaneous bilateral thyroid follicular cell carcinoma (subtype: compact cellular carcinoma) with C-cell complexes in a male beagle

Shingo Miyazaki, Takashi Ogawa, Tomoya Onozato, Yuji Okuhara et autres

We report the features of spontaneous bilateral thyroid follicular cell carcinoma in a 10-year-old male beagle. Necropsy revealed bilateral masses on the trachea, corresponding to the left and right sides of the thyroid gland. The masses were elastic, encapsulated, and distinct, with …

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Clinical impact of helicopter transport with a physician in cardiogenic shock complicating acute coronary syndrome

Yudhavir Singh, Manabu Ogita, Satoru Suwa, Tomoya Onozato et autres

Abstract Introduction Cardiogenic shock (CS) remains the leading cause of death in patients with acute coronary syndrome (ACS). Helicopter transport with a physician may improve the prognosis through reduction of the ischemic time and an early critical care. However, the impact of …

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Long-term outcome after unprotected left main percutaneous coronary intervention in patients with acute myocardial infarction complicated by cardiogenic shock: a landmark analysis

Shoichiro Yatsu, Mihoko Ogita, Yogesh S. Singh, Tomoya Onozato et autres

Abstract Funding Acknowledgements None. Background Early revascularization of culprit arteries has demonstrated to improve outcomes in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS), however, little is known about long-term outcome after unprotected left main (LM) percutaneous coronary intervention …

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Spontaneous adenocarcinoma with giant cell formation in the accessory sex glands in a male Sprague-Dawley rat

Shingo Miyazaki, Takashi Ogawa, Tomoya Onozato, Yuji Okuhara et autres

In this study, we report the features of an adenocarcinoma with giant cell formation spontaneously occurring in the accessory sex glands of a male 10-month-old Sprague-Dawley rat. A milky white mass was found in the region corresponding to the left seminal vesicle …

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Longitudinal analysis of motor symptoms and histopathology in woozy mice, a model of cerebellar ataxia

Takemitsu Hayashi, Tomoya Onozato, Isao Wanajo, Morimichi Hayashi et autres

Woozy (wz) mice develop ataxia and carry a mutation in the Sil1 gene. Homozygous wz mice have been characterized histopathologically, but no details of their motor function have been reported. In the present study, to comprehensively understand the relationship between symptomatic progression …

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Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation

Toshihiro Inoue, Masaaki Takemura, Nobuhiko Fushimi, Yoshikazu Fujimori et autres

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Axonal TDP‐43 aggregates in sporadic amyotrophic lateral sclerosis

Tomoya Onozato, Asa Nakahara, Emi Suzuki‐Kouyama, Akiyo Hineno et autres

AIMS: Axonal aggregates of phosphorylated (p-) transactive response DNA-binding protein 43 kDa (TDP-43) in sporadic amyotrophic lateral sclerosis (sALS) were examined in relation to propagation of the protein in the nervous system. METHODS: Brains and spinal cords of Japanese patients with sALS …

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Spontaneous cutaneous soft tissue sarcoma with differentiation into fibroblasts in a Sprague-Dawley rat

Takashi Ogawa, Tomoya Onozato, Yuji Okuhara, Tatsuya Nagasawa et autres

A small mass with an ulcer was found in the skin of the dorsal cervix of a 7-month-old male Sprague-Dawley rat. Histologically, the central region of the tumor showed a high cellular density with oval-shaped tumor cells arranged in an alveolar pattern …

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Effects of male sexual maturity of reproductive endpoints relevant to DART studies in Wistar Hannover rats

Ikuro Takakura, Dianne M. Creasy, Ryohei Yokoi, Yukari Terashima et autres

Wistar Hannover rats have been utilized as one of major strains in regulatory toxicology studies. This study was performed to verify the appropriate age of male sexual maturity in the development and reproductive toxicity (DART) study in Wistar Hannover rats (RccHan:WIST) by …

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