Yogesh S. Singh

Progress in 17β-HSD5 Inhibitor Discovery: Mechanistic Basis, SAR Trends, and Therapeutic Potential

Suyash Torawane, Pooja Ratre, Yogesh S. Singh, Shilpa Mandpe et autres

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Structure‐Based De Novo Design of Novel Dual DPP IV and PTP 1B Inhibitors (DDPI's)

Yogesh S. Singh, Suresh Thareja

Inhibition of DPP IV and PTP 1B constitutes a legitimate approach in modulating glucose homeostasis, thereby representing a viable therapeutic strategy for managing T2DM. This study employed a novel structure-based de novo design approach for developing dual DPP IV and PTP 1B …

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Nanotechnology and Applications

Yogesh S. Singh, Sunny Kumar Sharma, Purnima Hazra

The fields of nanoscience and nanotechnology are rapidly becoming the most exciting sciences due to the numerous applications that they have in a wide variety of various fields. The study of structures and molecules on nanometer ranging from 1 to 100 nm …

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Nanotechnology in agriculture

Yogesh S. Singh

Ensuring there is sufficient food for the world’s constantly increasing population is the most challenging global problem. By the year 2050, there will be approximately nine billion individuals on the Earth. Projections show that the world’s food consumption is likely to have …

Pyrimidine‐2,4‐dione‐Based DPP‐4 Inhibitors: A Structure‐Guided Multifaced 3D‐QSAR and Molecular Dynamics Studies

Rupali Kohal, Preety Kumari, Priya Bisht, Yogesh S. Singh et autres

Abstract DPP‐4 inhibitors have demonstrated efficacy in preventing incretin degradation, offering therapeutic potential for managing type 2 diabetes mellitus. Pyrimidine‐2,4‐dione‐based compounds have been identified as promising DPP‐4 inhibitors, exemplified by the approved drug alogliptin. This study conducted structure‐guided alignment‐dependent Gaussian field‐ and …

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In Silico Molecular Dynamics and 3D‐QSAR Study on Thiazolidinedione Derivatives as Dual Inhibitors of DPP IV and PTP1B (DDPI's) for the Management of T2DM

Yogesh S. Singh, Suresh Thareja

Abstract Simultaneous inhibition of dipeptidyl peptidase IV and protein tyrosine phosphatase 1B as DDPI's emerged as a therapeutic intervention for the management of T2DM. In the present study, we have employed molecular dynamics simulation in conjugation with the field‐based 3D QSAR studies …

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Identification of Novel Thiazolidinedione Based Pancreatic Lipase Inhibitors for the Management of Obesity Using In Silico Approach

Rakesh Khator, Yogesh S. Singh, Vivek Asati, Vikramdeep Monga

Abstract Accumulation of excessive fat in the body is an indication of obesity, which is becoming an alarming health concern around the world. Pancreatic lipase has been found to have a promising role in the digestion of dietary fats thereby inhibition of …

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Long-term outcome after unprotected left main percutaneous coronary intervention in patients with acute myocardial infarction complicated by cardiogenic shock: a landmark analysis

Shoichiro Yatsu, Mihoko Ogita, Yogesh S. Singh, Tomoya Onozato et autres

Abstract Funding Acknowledgements None. Background Early revascularization of culprit arteries has demonstrated to improve outcomes in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS), however, little is known about long-term outcome after unprotected left main (LM) percutaneous coronary intervention …

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Exploring the Potential of Essential Oil from Plectranthus amboinicus Leaves against Breast Cancer: In vitro and In silico Analysis

K.C. Gupta, Pranay Gautre, Avadh Biharee, Yogesh S. Singh et autres

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Structure-Based De Novo Designing of Novel Dual Dipeptidyl Peptidase IV and Protein Tyrosine Phosphate 1b Inhibitors (Ddpi’S): An in Silico Study

Yogesh S. Singh, Suresh Thareja

An amalgamated molecular dynamic and Gaussian based 3D-QSAR study for the design of 2,4-thiazolidinediones as potential PTP1B inhibitors

Avadh Biharee, Yogesh S. Singh, Swanand Kulkarni, Kailash Jangid et autres

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Polycystic ovary syndrome: Current scenario and future insights

Swanand Kulkarni, Khushi Anil Gupta, Pooja Ratre, Pradyumna Kumar Mishra et autres

Polycystic ovary syndrome (PCOS) prevails in approximately 33% of females of reproductive age globally. Although the root cause of the disease is unknown, attempts are made to clinically manage the disturbed hormone levels and symptoms arising due to hyperandrogenism, a hallmark of …

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