Jean‐Léon Thomas

Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels

Marie-Renée El Kamouh, Myriam Spajer, Ruchith Singhabahu, Anne-Laure Joly Marolany et autres

Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure and dural venous sinus stenoses, which can be relieved by venous stenting. Here we investigated whether venous blood flow may play a role in controlling brain pressure. Using magnetic resonance imaging in …

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Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition

Nickoleta Delivanoglou, Kennedi T. Todd, Francisco Almeida, Shanon Rego et autres

Sex and apolipoprotein E ε4 (APOE4) interact to alter the risk for Alzheimer's disease and other neurodegenerative disorders. Herein, we show sex-specific differences in immune activation and lymphatic function in the meningeal dura of humanized female and male mice expressing two alleles …

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RIG-I RNA agonist activates immunostimulatory macrophages to enhance checkpoint immunotherapy for glioblastoma

Xu Han, Sungwoon Lee, Felipe Leser, Olga Fedorova et autres

Abstract Glioblastoma (GBM), the most frequent and aggressive primary brain tumor, remains refractory to all current therapies including surgical resection, chemotherapy, radiotherapy and immunotherapy. Immunosuppressive mechanisms in the GBM tumor microenvironment contribute to the lack of anti-tumor adaptive immunity. We found that …

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Resolving the mysteries of brain clearance and immune surveillance

Jonathan Kipnis, Helene Benveniste, Anne Eichmann, Jean‐Léon Thomas et autres

Recent advances are transforming our understanding of brain fluid dynamics, highlighting cerebrospinal fluid (CSF) flow as a key process in brain waste clearance. While debates persist regarding its anatomical pathways and regulatory mechanisms, certain core principles have become widely accepted. CSF influx …

us, fr, nl, se, de, no, gb, il, nz (code pays fourni par la source)

CNSC-38. TARGETING UNC5B INDUCES BLOOD-BRAIN BARRIER PERMEABILITY AND IMPROVES CHEMOTHERAPY DELIVERY AND EFFICACY IN GLIOBLASTOMA

Felipe Saceanu Leser, Juliette Delongee, Jessica Furtado, Bartlomiej Bartkowiak et autres

Abstract The blood-brain barrier (BBB) plays a critical role in protecting the central nervous system (CNS) from toxins and pathogens while maintaining CNS homeostasis and function. However, this tightly regulated impermeability also poses a major challenge for delivery of therapeutic agents during …

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Murine Model of Cerebral Venous Outflow Occlusion Through Bilateral Ligation of Jugular Veins

Marie-Renée El Kamouh, Myriam Spajer, Marie‐Charlotte Bourrienne, Anne-Laure Joly Marolany et autres

Lymphatic vessels play a key role in maintaining fluid homeostasis and immune surveillance within tissues. At the brain's border, the dural meninges contain lymphatic vessels closely neighboring venous sinuses. In humans, idiopathic intracranial hypertension (IIH) is associated with stenosis of dural venous …

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Fluid and Waste Clearance in Central Nervous System Health and Diseases

Marie-Renée El Kamouh, Stéphanie Lenck, Stéphane Lehéricy, Helene Benveniste et autres

Background: In respect to the circulatory system, the central nervous system (CNS) differs from other organs in the body by three main features. First, the CNS is surrounded by a compartment filled with cerebrospinal fluid (CSF). Second, the CNS is devoid of …

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Meningeal lymphatics-microglia axis regulates synaptic physiology

Kyungdeok Kim, Daviti Abramishvili, Siling Du, Zachary Papadopoulos et autres

Meningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. Previous studies have demonstrated that dysfunctional meningeal lymphatics evoke behavioral changes, but the neural mechanisms underlying these changes have remained elusive. Here, we show …

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Cerebral Venous Blood Flow Regulates Brain Fluid Clearance via Meningeal Lymphatics

Marie-Renée El Kamouh, Myriam Spajer, Ruchith Singhabahu, Kurt A. Sailor et autres

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Cerebral Venous Blood Flow Regulates Brain Fluid Clearance via Dural Lymphatics

Marie-Renée El Kamouh, Myriam Spajer, Ruchith Singhabahu, Kurt A. Sailor et autres

Abstract The vascular system regulates brain clearance through arterial blood flow and lymphatic drainage of cerebrospinal fluid (CSF). Idiopathic intracranial hypertension (IIH), characterized by elevated intracranial pressure and dural venous sinus stenoses, can be treated by restoring venous blood flow via venous …

fr, us (code pays fourni par la source)

Rewiring of the glymphatic landscape in metabolic disorders

Bandy Chen, David Meseguer, Stéphanie Lenck, Jean‐Léon Thomas et autres

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Impact of jugular vein ligation on cerebrospinal fluid clearance from G-lymphatic system in mice

Anthony Ruze, Laura Mouton, Ruchith Singhabahu, Myriam Spajer et autres

Motivation: Cerebral venous outflow abnormalities have been linked to various neurological disorders, necessitating a detailed understanding of their impact on brain and lymphatic perfusion. This study aimed to investigate the G-lymphatic system change following bilateral jugular vein ligation (JVL) in mice. Goal(s): …