Marie‐Charlotte Bourrienne

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot et autres

OBJECTIVES: Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to …

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Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels

Marie-Renée El Kamouh, Myriam Spajer, Ruchith Singhabahu, Anne-Laure Joly Marolany et autres

Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure and dural venous sinus stenoses, which can be relieved by venous stenting. Here we investigated whether venous blood flow may play a role in controlling brain pressure. Using magnetic resonance imaging in …

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Murine Model of Cerebral Venous Outflow Occlusion Through Bilateral Ligation of Jugular Veins

Marie-Renée El Kamouh, Myriam Spajer, Marie‐Charlotte Bourrienne, Anne-Laure Joly Marolany et autres

Lymphatic vessels play a key role in maintaining fluid homeostasis and immune surveillance within tissues. At the brain's border, the dural meninges contain lymphatic vessels closely neighboring venous sinuses. In humans, idiopathic intracranial hypertension (IIH) is associated with stenosis of dural venous …

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Neutrophil extracellular traps block endogenous and intravenous thrombolysis-induced fibrinolysis in large vessel occlusion acute ischemic stroke

Jean‐Philippe Désilles, Mialitiana Solo Nomenjanahary, Lucas Di Meglio, Fatima Zemali et autres

Abstract Background Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) due to large vessel occlusion (LVO) is frequent but its causes remain elusive. Several non-exclusive mechanisms have been proposed to explain IVT failure, including failed delivery of tPA and inhibition of …

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Cerebral Venous Blood Flow Regulates Brain Fluid Clearance via Meningeal Lymphatics

Marie-Renée El Kamouh, Myriam Spajer, Ruchith Singhabahu, Kurt A. Sailor et autres

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Comparative Effects of Glenzocimab and Eptifibatide on Bleeding Severity in 2 Mouse Models of Intracranial Hemorrhage

Sébastien Dupont, Héloïse Lebas, Sabrina Mavouna, E Pascal et autres

BACKGROUND: Antiplatelet drugs represent potential candidates for protecting the penumbral microcirculation during cerebral ischemia and improving the benefits of arterial recanalization in ischemic stroke. Yet while the efficacy of such adjuvant strategies has been shown to be highly time dependent, antiplatelet therapy …

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Cerebral Venous Blood Flow Regulates Brain Fluid Clearance via Dural Lymphatics

Marie-Renée El Kamouh, Myriam Spajer, Ruchith Singhabahu, Kurt A. Sailor et autres

Abstract The vascular system regulates brain clearance through arterial blood flow and lymphatic drainage of cerebrospinal fluid (CSF). Idiopathic intracranial hypertension (IIH), characterized by elevated intracranial pressure and dural venous sinus stenoses, can be treated by restoring venous blood flow via venous …

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Impaired fibrinolysis in JAK2V617F-related myeloproliferative neoplasms

Marie‐Charlotte Bourrienne, Stéphane Loyau, Dorothée Faille, Juliette Gay et autres

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Sensitivity and specificity of strategies to identify patients with hemostasis abnormalities leading to an increased risk of bleeding before scheduled intervention: the Hemorisk study

Nadine Ajzenberg, Dan Longrois, Dorothée Faille, Christian de Tymowski et autres

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Exacerbation of thromboinflammation by JAK2 V617F mutation worsens the prognosis of cerebral venous sinus thrombosis

Marie‐Charlotte Bourrienne, Véronique Le Cam Duchez, Dorothée Faille, Carine Farkh et autres

ABSTRACT: Cerebral venous sinus thrombosis (CVST) is an uncommon venous thromboembolic event accounting for <1% of strokes resulting in brain parenchymal injuries. JAK2V617F mutation, the most frequent driving mutation of myeloproliferative neoplasms, has been reported to be associated with worse clinical outcomes …

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Challenges in the Monitoring of Therapeutic Plasma Exchange during Acute Heparin-Induced Thrombocytopenia in Adults under ECMO

Candice Cavalie, Nicolas Gendron, Elie Kantor, Sophie Provenchère et autres

Therapeutic plasma exchange (TPE) has been proposed to remove heparin-induced thrombocytopenia (HIT) antibodies before planned thoracic surgery in patients with acute HIT and to allow brief re-exposure to heparin during surgery. In patients on extracorporeal membrane oxygenation (ECMO), simultaneous administration of TPE …

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Pancytopenia related to acquired sea‐blue histiocytosis during chronic parenteral nutrition

Marie‐Charlotte Bourrienne, Imen Ben Salah, Emmanuelle de Raucourt, Jérôme Debus et autres

Bone marrow smear showing histiocytes (black arrow) containing sea blue granules stained with May-Grünwald Giemsa.

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