2025
conference-abstract
OpenAlex
Felipe Saceanu Leser, Juliette Delongee, Jessica Furtado, Bartlomiej Bartkowiak et autres
Abstract The blood-brain barrier (BBB) plays a critical role in protecting the central nervous system (CNS) from toxins and pathogens while maintaining CNS homeostasis and function. However, this tightly regulated impermeability also poses a major challenge for delivery of therapeutic agents during …
us, fr, ca, br
(code pays fourni par la source)
2025
article
OpenAlex
Lanya Tseng, Bartlomiej Bartkowiak, Nada Z. Pejcic, Sergio Munoz-Correa et autres
us, cn
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Jessica Furtado, Luiz Henrique Geraldo, Felipe Saceanu Leser, Bartlomiej Bartkowiak et autres
The integrity of the blood–retina barrier (BRB) is crucial for phototransduction and vision, by tightly restricting transport of molecules between the blood and surrounding neuronal cells. Breakdown of the BRB leads to the development of retinal diseases. Here, we show that Netrin-1/Unc5b …
us, br, fr
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Bartlomiej Bartkowiak, Jinlei Li
In a recent meta-analysis, Cui et al found that the Erector Spinae Plane (ESP) block reduced opioid consumption after various surgeries, including spine procedures. Thus, pioneer anesthesiologists have begun to leverage the ESP block for patients undergoing spine procedures. However, as is …
us
(code pays fourni par la source)
2023
book-chapter
OpenAlex
Jodi-Ann Oliver, Lori-Ann Oliver, Bartlomiej Bartkowiak
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Brian Magnuson, Karan Bedi, Ishwarya Venkata Narayanan, Bartlomiej Bartkowiak et autres
The cyclin-dependent kinase CDK12 has garnered interest as a cancer therapeutic target as DNA damage response genes are particularly suppressed by loss of CDK12 activity. In this study, we assessed the acute effects of CDK12 inhibition on transcription and RNA processing using …
us
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Bartlomiej Bartkowiak, Christopher M. Yan, Erik J. Soderblom, Arno L. Greenleaf
HeLa cell line to investigate CDK12 activity-dependent phosphorylation events in human cells. Characterizing the phospho-proteome before and after selective inhibition of CDK12 activity by the analog 1-NM-PP1, we identified 5,644 distinct phospho-peptides, among which were 50 whose average relative amount decreased more …
us
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Bartlomiej Bartkowiak, Ashley M. Snyder, Andrew J. Benjamin, Andrew Schneider et autres
OBJECTIVE: Assess the accuracy of 3 early warning scores for predicting severe adverse events in postoperative inpatients. SUMMARY OF BACKGROUND DATA: Postoperative clinical deterioration on inpatient hospital services is associated with increased morbidity, mortality, and cost. Early warning scores have been developed …
us
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Ryan Patrick McKillip, Olwen Mary Hahn, Bartlomiej Bartkowiak, Carol A. Rosenberg et autres
us
(code pays fourni par la source)
Accès ouvert
2016
article
OpenAlex
Tinghu Zhang, Nicholas P. Kwiatkowski, Sarah E. Dixon-Clarke, Brian J. Abraham et autres
us, gb, de
(code pays fourni par la source)
Accès ouvert
2016
article
OpenAlex
Tinghu Zhang, Nicholas P. Kwiatkowski, Sarah E. Dixon-Clarke, Brian J. Abraham et autres
Author: Zhang, T. et al.; Genre: Journal Article; Issued: 2016-10; Keywords: Cancer therapy, Kinases, Small molecules, Transcription ; Title: Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
Accès ouvert
2016
dataset
OpenAlex
Sarah E. Dixon-Clarke, Jonathan M. Elkins, Siwei Cheng, Tinghu Zhang et autres
Cyclin-dependent kinase 12 (CDK12) phosphorylates RNA Pol II C-terminal domain (CTD) to promote transcriptional elongation of large DNA damage response genes. CDK12 is frequently mutated or amplified in cancer and its loss sensitises cells to DNA damage. Here we present 3 crystal …