Elizabeth W. Tucker

Host-directed nanotherapy for the treatment and imaging of tuberculous meningitis

Elizabeth W. Tucker, John Y. Kim, Clara Erice, Anjali Sharma et autres

Rationale: Tuberculous meningitis (TB meningitis) is a devastating infection where the host immune response drives brain injury.Standard adjunctive corticosteroids often fail to prevent neurological sequelae or improve survival in many populations.Host-directed therapies that can cross the blood-brain barrier (BBB) and reduce neuroinflammation …

us (code pays fourni par la source)

Tuberculous meningitis alters the proteomic landscape of brain-derived extracellular vesicles

Blanca V. Rodriguez, Nerketa N. L. Damiba, Nicole Beaubien, D Pucă et autres

Tuberculous meningitis (TB meningitis), the deadliest form of Mycobacterium tuberculosis infection, leads to mortality and severe neurological disability despite standard therapy. Brain injury and microglial activation are major determinants of outcome, yet the mechanisms linking infection, inflammation and neuronal injury remain poorly …

us (code pays fourni par la source)

A clinical practice guideline for tuberculous meningitis

Joseph Donovan, Fiona V Cresswell, Elizabeth W. Tucker, Angharad Davis et autres

vn, Ouganda, us, gb, Afrique du Sud, kh, nl, fr, au, id, in (code pays fourni par la source)

18F-Fluorodeoxysorbitol PET for noninvasive detection of invasive mold infections: preclinical and first-in-human studies

Carlos E Ruiz-Gonzalez, Oscar J Nino-Meza, Medha Singh, Yuderleys Masias-Leon et autres

Invasive mold infections are a major cause of mortality in immunosuppressed and cancer patients. Diagnosis is challenging, requiring invasive procedures or reliance on fungal biomarkers with limited sensitivity and an inability to detect non-Aspergillus molds. Here, we perform whole-body 18F-fluorodeoxysorbitol (18F-FDS) positron …

us (code pays fourni par la source)

Dynamic 11C– Para –Aminobenzoic Acid Positron Emission Tomography/Computed Tomography for Visualizing Pulmonary Mycobacteroides abscessus Infections

Yuderleys Masias-Leon, Carlos E Ruiz-Gonzalez, Oscar J Nino-Meza, Medha Singh et autres

Abstract Rationale Mycobacteroides abscessus infections affect immunocompromised patients and those with underlying pulmonary disease. Conventional imaging cannot distinguish M. abscessus infections from underlying pulmonary disease or sterile inflammation, requiring invasive procedures for definitive diagnosis. Objectives We evaluated 11C-para-aminobenzoic acid (11C-PABA), a chemically …

us (code pays fourni par la source)

P-2128. First-in-human 18F-Fluorodeoxysorbitol PET for Noninvasive Diagnosis of Invasive Fungal Infections

Carlos E Ruiz-Gonzalez, Oscar J Nino-Meza, Medha Singh, Yuderleys Masias-Leon et autres

Abstract Background Invasive mold infections are increasingly prevalent in immunosuppressed patients and associated with high mortality. Definitive diagnosis is challenging and may require invasive procedures (bronchoalveolar lavage, biopsy) or rely on biomarkers, e.g., galactomannan, which has limited sensitivity for Aspergillus and does …

us (code pays fourni par la source)

643. Dynamic 11C-PABA PET/CT Imaging for Visualizing Pulmonary Mycobacteroides abscessus Infection: Animal and Human studies

Yuderleys Masias-Leon, Oscar J Nino-Meza, Amy Kronenberg, Kelly Flavahan et autres

Abstract Background Non-tuberculous mycobacteria (NTM) primarily affect patients with structural lung damage with Mycobacteroides abscessus being the second most prevalent NTM in the U.S. Conventional imaging tools cannot distinguish infection from underlying inflammation, and definitive diagnosis often requires invasive procedures. Therefore, development …

us (code pays fourni par la source)

Spatially heterogeneous lipid dysregulation in tuberculous meningitis

John Kim, Ian Spears, Clara Erice, Hye‐Young Kim et autres

Tuberculous (TB) meningitis is the deadliest form of extrapulmonary TB which disproportionately affects children and immunocompromised individuals. Studies in pulmonary TB have shown that Mycobacterium tuberculosis can alter host lipid metabolism to evade the immune system. Cholesterol lowering drugs (i.e., statins) reduce …

us (code pays fourni par la source)

18F-Fluorodeoxysorbitol PET for Noninvasive Detection of Invasive Mold Infections in Patients

Sanjay Kumar Jain, Carlos E Ruiz-Gonzalez, Oscar Nino Meza, Yuderleys Masias-Leon et autres

us (code pays fourni par la source)

Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs

Xueyi Chen, Bhavatharini Arun, Oscar J Nino-Meza, Mona O. Sarhan et autres

Tuberculosis (TB) remains a leading cause of death, but antibiotic treatments for tuberculous meningitis, the deadliest form of TB, are based on those developed for pulmonary TB and not optimized for brain penetration. Here, we perform first-in-human dynamic 18F-pretomanid positron emission tomography …

us, in (code pays fourni par la source)

Dynamic PET Reveals Compartmentalized Brain and Lung Tissue Antibiotic Exposures

Sanjay Kumar Jain, Xueyi Chen, Bhavatharini Arun, Oscar Nino Meza et autres

us (code pays fourni par la source)

Linezolid does not improve bactericidal activity of rifampin-containing first-line regimens in animal models of TB meningitis

Elizabeth W. Tucker, Camilo A. Ruiz-Bedoya, Filipa Mota, Clara Erice et autres

Tuberculous meningitis (TB meningitis) is the most devastating form of tuberculosis (TB) and there is a critical need to optimize treatment. Linezolid is approved for multidrug resistant TB and has shown encouraging results in retrospective TB meningitis studies, with several clinical trials …

us (code pays fourni par la source)