Dynamic 11C– Para –Aminobenzoic Acid Positron Emission Tomography/Computed Tomography for Visualizing Pulmonary Mycobacteroides abscessus Infections
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Le résumé fourni par la source
Abstract Rationale Mycobacteroides abscessus infections affect immunocompromised patients and those with underlying pulmonary disease. Conventional imaging cannot distinguish M. abscessus infections from underlying pulmonary disease or sterile inflammation, requiring invasive procedures for definitive diagnosis. Objectives We evaluated 11C-para-aminobenzoic acid (11C-PABA), a chemically identical radioanalog of PABA, to detect and localize infections due to M. abscessus. Methods In vitro uptake assays were performed to test the metabolism and accumulation of PABA into M. abscessus reference and clinical isolates. Dynamic 11C-PABA positron emission tomography (PET) was performed in a mouse model of M. abscessus pulmonary infection and in a patient with microbiologically confirmed M. abscessus pulmonary infection (NCT 05611905). Measurements and Main Results 11C-PABA was intracellularly metabolized by M. abscessus to 11C-7,8-dihydropteroate. In addition, the reference strain and all 13 randomly chosen clinical isolates, including 3 resistant to trimethoprim–sulfamethoxazole, rapidly accumulated PABA. No PABA accumulation was noted by heat-inactivated bacteria or mammalian cells. Dynamic 11C-PABA PET in a mouse model of M. abscessus pulmonary infection rapidly distinguished infection from sterile inflammation and also accurately monitored response to antibiotic treatment. Finally, dynamic 11C-PABA PET in a 33-year-old woman with cystic fibrosis and microbiologically confirmed M. abscessus pulmonary infection was safe and demonstrated significantly higher and sustained PET uptake in the affected lesions. Conclusions 11C-PABA PET is an innovative, clinically translatable, noninvasive, bacteria-specific diagnostic to differentiate M. abscessus infections from underlying pulmonary disease in patients. This tool could also help in monitoring treatment responses and enable precision medicine approaches for patients with complicated infections.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Dynamic 11C– <i>Para</i> –Aminobenzoic Acid Positron Emission Tomography/Computed Tomography for Visualizing Pulmonary <i>Mycobacteroides abscessus</i> Infections
- Date Crossref
- 01/07/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Johns Hopkins University pays non établi dans la noticeUniversité ou école supérieure
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The State University of New Jersey Rutgers pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Medicine pays non établi dans la noticeÉtablissement de santé
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Johns Hopkins Hospital pays non établi dans la noticeÉtablissement de santé
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Center for Infection and Inflammation Imaging Research pays non établi dans la noticeInstitution
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Department of Pediatrics pays non établi dans la noticeInstitution
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Johns Hopkins School of Medicine Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Department of Anesthesiology and Critical Care Medicine pays non établi dans la noticeInstitution
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Rutgers University – New Jersey Medical School Department of Pharmacology pays non établi dans la noticeUniversité ou école supérieure
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Russell H. Morgan Department of Radiology and Radiological Science pays non établi dans la noticeInstitution
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Department of Pathology pays non établi dans la noticeInstitution
Johns Hopkins University, Rutgers — The State University of New Jersey et Johns Hopkins Medicine, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.