Iris Helfrich

Deciphering melanoma brain metastases: Role of cellular plasticity and metastatic origin

Shanice J. Heidenreich, Jessica Faber, Markus Lorke, Dayana Herrera-Rios et autres

The treatment of brain metastases in malignant melanoma remains one of the major clinical challenges despite immuno-oncological and targeted therapies. Here, we revealed that successful colonization of the brain by melanoma cells is primarily determined by two complementary factors: (i) intrinsic phenotypic …

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Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander Thomas Bauer, Gergely Morten Solecki, Chanté D. Mayer et autres

Supplementary Movie 3

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander Thomas Bauer, Gergely Morten Solecki, Chanté D. Mayer et autres

Supplementary Movie 6

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander Thomas Bauer, Gergely Morten Solecki, Chanté D. Mayer et autres

Supplementary Movie 5

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander Thomas Bauer, Gergely Morten Solecki, Chanté D. Mayer et autres

Supplementary Movie 4

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander Thomas Bauer, Gergely Morten Solecki, Chanté D. Mayer et autres

Supplementary Movie 1

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander Thomas Bauer, Gergely Morten Solecki, Chanté D. Mayer et autres

Supplementary Figures and Figure legends, Supplementary Video legends and supplementary materials and methods

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander Thomas Bauer, Gergely Morten Solecki, Chanté D. Mayer et autres

Supplementary Movie 2

Identification and characterization of tertiary lymphoid structures in brain metastases

Sadaf Shabbir Mughal, Yvonne Reiss, Jörg Felsberg, Lasse Meyer et autres

Brain metastases (BrM) are the most common cancers in the brain and linked to poor prognosis. Given the high incidence and often limited treatment options, understanding the complexity of the BrM tumor microenvironment is crucial for the development of novel therapeutic strategies. …

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Serpins A1/A3 within tumor-derived extracellular vesicles support pro-tumoral bias of neutrophils in cancer

Maksim Domnich, Ekaterina Pylaeva, Elena Siakaeva, Nastassia Kabankova et autres

Abstract Neutrophils are known to play an important regulatory role during tumor progression in several types of cancer. However, the mechanisms responsible for their tumorigenic bias and extended lifespan in cancer are not clear to date. This study uncovers a previously unknown …

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RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma

Sara Egea‐Rodriguez, Renáta Váraljai, Thierry M. Nordmann, Manuel Philip et autres

BACKGROUND: Cancer immunotherapy has transformed metastatic cancer treatment, yet challenges persist regarding therapeutic efficacy. RECQL4, a RecQ-like helicase, plays a central role in DNA replication and repair as part of the DNA damage response, a pathway implicated in enhancing efficacy of immune …

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Spatial proteomics reveals sirtuin 1 to be a determinant of T-cell infiltration in human melanoma

Jan-Malte Placke, Jenny Bottek, Renáta Váraljai, Batool Shannan et autres

BACKGROUND: The tumour microenvironment significantly influences the clinical response of patients to therapeutic immune checkpoint inhibition (ICI), but a comprehensive understanding of the underlying immune-regulatory proteome is still lacking. OBJECTIVES: To decipher targetable biologic processes that determine tumour-infiltrating lymphocytes (TiLs) as a …

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