Elena Siakaeva

CITE-seq of murine bone marrow plasmacytoid dendritic cells and haematopoietic progenitor cells in sepsis

Johannes Andreas Korfhage, Elena Siakaeva, Mahamudul Hasan Bhuyan, Bettina Budeus et autres

Abstract This dataset contains single-cell transcriptomic and surface protein profiles of bone marrow cells enriched for plasmacytoid dendritic cells (pDCs) and haematopoietic progenitor populations from septic and sham-operated mice. Sepsis was induced in BALB/c wild-type mice using cecal ligation and puncture (CLP) …

de (code pays fourni par la source)

Disturbed metabolic adaptation drives natural killer cell dysfunction in association with nosocomial infection during human sepsis

André van der Wurff, Monika Gambusz, Bettina Budeus, Maren Claus et autres

BACKGROUND: Patients with sepsis are highly susceptible to detrimental nosocomial infections. During bacterial infection, natural killer (NK) cells release Interferon (IFN) γ that drives the elimination of invading pathogens. Interleukin (IL) 12 in synergy with other cytokines increases sensing and uptake of …

de, mt (code pays fourni par la source)

Serpins A1/A3 within tumor-derived extracellular vesicles support pro-tumoral bias of neutrophils in cancer

Maksim Domnich, Ekaterina Pylaeva, Elena Siakaeva, Nastassia Kabankova et autres

Abstract Neutrophils are known to play an important regulatory role during tumor progression in several types of cancer. However, the mechanisms responsible for their tumorigenic bias and extended lifespan in cancer are not clear to date. This study uncovers a previously unknown …

de, pl (code pays fourni par la source)

Turning Neutrophils into guardians: Targeting neutrophil STAT3 signaling impairs tumor growth via the modulation of their anti-tumor bias

Irem Özel, Ekaterina Pylaeva, Elena Siakaeva, Nastassia Kabankova et autres

Stat3 signaling pathway play a crucial role in pro-tumoral polarization of neutrophils. In this study, we aim to investigate the role of neutrophil-specific STAT3 deficiency (NStat3-/-) on the tumor development in head and neck cancer (HNC).We found that, NStat3-/- mice show significantly …

de (code pays fourni par la source)

Nonfunctional TGF-β/ALK1/ENG signaling pathway supports neutrophil proangiogenic activity in hereditary hemorrhagic telangiectasia

Inga Duerig, Ekaterina Pylaeva, Irem Ozel, Sami Wainwright et autres

The transforming growth factor β (TGF-β)/ALK1/ENG signaling pathway maintains quiescent state of endothelial cells, but at the same time, it regulates neutrophil functions. Importantly, mutations of this pathway lead to a rare autosomal disorder called hereditary hemorrhagic telangiectasia (HHT), characterized with abnormal …

de (code pays fourni par la source)

Human neutrophils support endothelial sprouting in hereditary hemorrhagic teleangiectasia

Inga Dürig, Ekaterina Pylaeva, Irem Oezel, Ilona Thiel et autres

Introduction Besides their antibacterial properties, neutrophils are known to be potent regulators of angiogenesis by facilitating the migration of endothelial cells via various mechanisms, including stimulation of endothelium and matrix degradation. Here, we aimed to investigate, if pro-angiogenic functions of neutrophils are …

de (code pays fourni par la source)

Humane Neutrophile unterstützen die Angiogenese bei hereditärer hämorrhagischer Teleangiektasie

Inga Dürig, Ekaterina Pylaeva, Irem Oezel, Ilona Thiel et autres

Einleitung Neutrophile Granulozyten sind sowohl ein wichtiger Bestandteil der Immunantwort als auch potente Regulatoren der Angiogenese. Patienten mit hereditärer hämorrhagischer Teleangiektasie (HHT) leiden an systemisch auftretenden Gefäßmalformationen. Ziel unserer Studie war es, den Einfluss Neutrophiler auf die Erkrankung zu analysieren. Methoden Im …

de (code pays fourni par la source)

During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes

Ekaterina Pylaeva, Georg Korschunow, Ilona Spyra, Sharareh Bordbari et autres

Tumor-draining lymph nodes (LNs) play a crucial role during cancer spread and in initiation of anti-cancer adaptive immunity. Neutrophils form a substantial population of cells in LNs with poorly understood functions. Here, we demonstrate that, during head and neck cancer (HNC) progression, …

de (code pays fourni par la source)

IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph Nodes

Timon Hussain, Maksim Domnich, Sharareh Bordbari, Ekaterina Pylaeva et autres

Tumor-draining lymph nodes (TDLNs) are the first organs where the metastatic spread of different types of cancer, including head and neck cancer (HNC), occurs and have therefore high prognostic relevance. Moreover, first anti-cancer immune responses have been shown to be initiated in …

de (code pays fourni par la source)

SIRT1 ‐mediated deacetylation of FOXO3a transcription factor supports pro‐angiogenic activity of interferon‐deficient tumor‐associated neutrophils

Sharareh Bordbari, Britta Mörchen, Ekaterina Pylaeva, Elena Siakaeva et autres

Abstract Angiogenesis plays an important role during tumor growth and metastasis. We could previously show that Type I interferon (IFN)‐deficient tumor‐associated neutrophils (TANs) show strong pro‐angiogenic activity, and stimulate tumor angiogenesis and growth. However, the exact mechanism responsible for their pro‐angiogenic shift …

de, us (code pays fourni par la source)

B-Helper Neutrophils in Regional Lymph Nodes Correlate with Improved Prognosis in Patients with Head and Neck Cancer

Ekaterina Pylaeva, Irem Ozel, Anthony Squire, Ilona Spyra et autres

The role of neutrophils during cancer formation and elimination is diverse. Here, for the first time, we investigate neutrophil helper cells (NBH), their influence on B cell activity in the regional lymph nodes (RLN) of head-and-neck cancer patients and the effect of …

de (code pays fourni par la source)

Pre-metastatic Niche Formation by Neutrophils in Different Organs

Elena Siakaeva, Jadwiga Jabłońska

de (code pays fourni par la source)