Renáta Váraljai

The role of KDM5B in creating synthetic vulnerabilities in combination with radiotherapy in melanoma cells

Safa Larafa, Merle Schaffrin, Peer Braß, Renáta Váraljai et autres

BACKGROUND: Cutaneous melanoma is the most aggressive type of skin cancer, with survival rates declining due to tumor heterogeneity and therapy resistance. Distinct subpopulations, including slow-cycling, therapy-resistant cells with high expression of the histone demethylase KDM5B, contribute to tumor progression and poor …

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Additional file 6 of The role of KDM5B in creating synthetic vulnerabilities in combination with radiotherapy in melanoma cells

Safa Larafa, Merle Schaffrin, Peer Braß, Renáta Váraljai et autres

Supplementary Material 6.

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Additional file 6 of The role of KDM5B in creating synthetic vulnerabilities in combination with radiotherapy in melanoma cells

Safa Larafa, Merle Schaffrin, Peer Braß, Renáta Váraljai et autres

Supplementary Material 6.

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Supplementary Figure 4 from BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment

Wei Liu, Paweł Stachura, Haifeng C. Xu, Renáta Váraljai et autres

Figure S4 shows the gating strategy of monocytes sorted from BAFF-expressing and control tumors

Supplementary Figure7 from BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment

Wei Liu, Paweł Stachura, Haifeng C. Xu, Renáta Váraljai et autres

Figure S7 shows the individual tumor growths comprising the main figures

Supplementary Table 3 from BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment

Wei Liu, Paweł Stachura, Haifeng C. Xu, Renáta Váraljai et autres

Supplementary Table 3 shows different PD-L1 cut-offs to stratify responders and non-responders to immunotherapy

Raising the iron curtain: Lactate's secret role in oxidative stress defense

Astrid Hensel, Renáta Váraljai, Shirley K. Knauer

The hypothesis presented here is that certain cell types under oxidative stress, such as cancer cells, reprogram their metabolism to accumulate lactate, along with cytosolic Fe 2+ within the labile iron pool, thereby establishing a metabolite-based H 2 O 2 detoxification system. …

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Redirecting resistance evolution in BRAF V600 melanoma by inhibition of the peroxiredoxin-thioredoxin system

Stefanie Egetemaier, Heike Chauvistré, Renáta Váraljai, Yichao Hua et autres

Summary Drug-tolerant persister cells (DTPs) exhibit remarkable cell state heterogeneity and phenotypic evolvability. However, the central question of how DTPs epigenetically coordinate their metabolic flexibility to adapt early to therapeutic stress remains unanswered. We have recently shown that the histone demethylase KDM5B, …

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RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma

Sara Egea‐Rodriguez, Renáta Váraljai, Thierry M. Nordmann, Manuel Philip et autres

BACKGROUND: Cancer immunotherapy has transformed metastatic cancer treatment, yet challenges persist regarding therapeutic efficacy. RECQL4, a RecQ-like helicase, plays a central role in DNA replication and repair as part of the DNA damage response, a pathway implicated in enhancing efficacy of immune …

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Spatial proteomics reveals sirtuin 1 to be a determinant of T-cell infiltration in human melanoma

Jan-Malte Placke, Jenny Bottek, Renáta Váraljai, Batool Shannan et autres

BACKGROUND: The tumour microenvironment significantly influences the clinical response of patients to therapeutic immune checkpoint inhibition (ICI), but a comprehensive understanding of the underlying immune-regulatory proteome is still lacking. OBJECTIVES: To decipher targetable biologic processes that determine tumour-infiltrating lymphocytes (TiLs) as a …

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Abstract 5019: Comprehensive pan-cancer analysis of cfDNA methylation marks in tumors reveals complex epigenetic regulatory circuits and diagnostic biomarkers

Smiths Lueong, Martin Metzenmacher, Gregor Zaun, Gina Lauren Mayer et autres

Abstract Early detection of tumor activity in clinically asymptomatic patients has the potential to improve quality of life and prevent unnecessary exposure to toxic therapies. DNA methylation is one of the most studied, stable, and fundamental epigenetic marks and represents a prominent …

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Anti-PD-(L)1 plus BRAF/MEK inhibitors (triplet therapy) after failure of immune checkpoint inhibition and targeted therapy in patients with advanced melanoma

Lea Jessica Albrecht, Florentia Dimitriou, Piyush Grover, Jessica C. Hassel et autres

BACKGROUND: Effective treatment options are limited for patients with advanced melanoma who have progressed on immune checkpoint inhibitors (ICI) and targeted therapies (TT). Preclinical models support the combination of ICI with TT; however, clinical trials evaluating the efficacy of triplet combinations in …

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