Xiaoju Men

A disulfidptosis- and glycolysis-related gene signature for prognostic stratification and characterization of the tumor microenvironment in lung adenocarcinoma

Xiaoju Men, Zhuting Jiang, Lingjuan Ye, Xinli Liu et autres

Lung adenocarcinoma (LUAD) exhibits profound metabolic plasticity and immune heterogeneity, contributing to poor outcomes. Disulfidptosis, a newly characterized disulfide stress-induced cell death, is closely linked to redox balance, while glycolysis constitutes a central metabolic program driving tumor progression. However, the prognostic relevance …

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Parameter Design and Development of Ultra-Narrowband Optical Frequency Discriminator for Application to Quantum Technology

Yuanqing Wang, Feng Chen, Jinghao Zhang, Tong Li et autres

The rapid development of quantum technology and single-photon LiDAR places ever-increasing demands on detection systems in terms of bandwidth suppression, wavelength stability, and transmission accuracy. Conventional narrowband filters, however, are falling short in sub-nanometer bandwidth control and high-temperature stability, thereby failing to …

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Enzymatic Ligation-Enhanced Catalytic Hairpin Assembly for Accelerated Kinetics with Restricted Leakage

Mengqing Sun, Yuting Ma, Huamin Yuan, Cong Su et autres

Enthalpy-driven catalytic hairpin assembly (CHA) suffers from an inherent trade-off, wherein enhanced reaction kinetics is inevitably accompanied by elevated nonspecific background. Catalytic hairpin assembly-and-cyclization (CHAC) integrates CHA with enzymatic ligation, allowing single-target-triggered multiple circularization events and thus bypassing the stoichiometric limitation of …

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Chrono-responsive polymer dots enable ultrafast forensic fingerprinting with time-resolved visualization and automated recognition

Yujuan Dai, Zhengkun Zhan, Yingrui Yue, Zhenhui Guo et autres

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Noninvasive Salivary Ketone Monitoring: A Ratiometric Pdot Biosensor toward Personalized Ketogenic Management

Mingyue Gong, Zhuli Wu, Shiyu Wang, Ziqing Yi et autres

β-Hydroxybutyrate (BHB), a key ketone body and metabolic biomarker, enables personalized ketogenic-diet management and metabolic-disease monitoring through rapid, noninvasive salivary detection. We present an NADH-responsive semiconducting polymer dot (Pdot) biosensor utilizing enzymatic catalysis of BHB to convert NAD + into NADH. This …

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Noninvasive point-of-care testing: From sensing technologies and wearable platforms to intelligent diagnostics

Mingyue Gong, Zhuli Wu, Yufang He, Jiaying Xiao et autres

Point-of-care testing (POCT) represents a significant innovation in healthcare diagnostics, driving the evolution of clinical practice and health management toward greater convenience and personalization. However, conventional invasive POCT techniques are constrained by patient discomfort, infection risk, and discontinuous monitoring inherent to blood …

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Machine Learning–Enhanced Fluorescence Cryptography with NADH ‐Responsive Polymer Dots

Zhengkun Zhan, Mingyue Gong, Zirui Zeng, Hangyu Liu et autres

The development of high security anticounterfeiting technologies is crucial to address the escalating demand for information security. Stimuli‐responsive fluorescent materials have garnered significant interest for advanced information encryption due to their dynamic signal outputs and compatibility with intelligent analysis tools. In this …

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Camouflaged Pdots leverage homologous targeting for NIR-II guided cancer theranostics

Xinli Liu, Ailin Duan, Fanghong Liu, Zeng Mengjun et autres

The development of efficient tumor-targeted phototheranostics presents a significant challenge for clinical translation. This work introduces biomimetic cancer cell membrane-coated polymer dots (CCM-Pdots) for second near-infrared window (NIR-II) photoacoustic imaging (PAI)-guided phototherapy. The CCM-Pdots exhibit exceptional photothermal conversion efficiency at 1064 nm. …

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Smart and Secure: Fluorescent Polymers Revolutionizing Anti‐Counterfeiting Strategies

Zhengkun Zhan, Site Li, Zhiyan Cheng, Xiaoju Men et autres

Abstract Traditional anti‐counterfeiting methods have become increasingly inadequate in combating sophisticated counterfeiting activities. Fluorescent polymer materials have attracted considerable attention owing to their exceptional optical properties, structurally tunable frameworks, and versatile processability. These materials have been widely utilized in the development of …

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Smartphone‐Powered Pdot Biosensors for Quantitative Phenylketonuria Screening at the Point of Care

Sile Deng, Zi-Hao Liu, Xiaoyan Shi, Zhengkun Zhan et autres

Current clinical management of hyperphenylalaninemia and phenylketonuria (PKU) lacks accessible, real-time diagnostic tools. To address this gap, a portable biosensing system integrating semiconducting polymer dot (Pdot) technology with miniaturized optics for rapid phenylalanine quantification is developed. The biosensor leverages phenylalanine dehydrogenase to …

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Effect of pretreatment of chemical mechanical polishing slurry on surface quality of Al2O3/TiO2 nanolaminates

Xiaoju Men, Jinhui Yang, Kaiyu Li, D.G. Wei et autres

Al2O3/TiO2 nanolaminates holds great promise for photodetection and integrated circuits, in which high-quality Al2O3/TiO2 nanolaminates with planarization are cornerstones. Chemical mechanical polishing (CMP) is the critical technology in the planarization of Al2O3/TiO2 nanolaminates. This study aims to optimize the polishing process used …

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Activatable fluorescent probes for imaging and diagnosis of hepatocellular carcinoma

Xiaoxiao Men, Fanghong Liu, Xuchao Wang, Ling Wang et autres

Liver cancer, specifically hepatocellular carcinoma (HCC), is a malignant neoplasm of the digestive system, characterized by exceptionally high morbidity and mortality rates on a global scale. Early detection and diagnosis are critical measures for enhancing the prognosis of patients diagnosed with HCC. …

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