Enzymatic Ligation-Enhanced Catalytic Hairpin Assembly for Accelerated Kinetics with Restricted Leakage
Mengqing Sun, Yuting Ma, Huamin Yuan, Cong Su et autres
Enthalpy-driven catalytic hairpin assembly (CHA) suffers from an inherent trade-off, wherein enhanced reaction kinetics is inevitably accompanied by elevated nonspecific background. Catalytic hairpin assembly-and-cyclization (CHAC) integrates CHA with enzymatic ligation, allowing single-target-triggered multiple circularization events and thus bypassing the stoichiometric limitation of …
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Analytical Chemistry