Benjamin Hänisch

Vaccination and Safe Living Strategies for Solid Organ Transplant Candidates and Recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice

Deepali Kumar, Robin Avery, Lara Danziger-Isakov, Victoria Hall et autres

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Pharmacodynamic profiles inform systematization, efficacy and whole-brain drug distribution profiles in 18 antidepressants

Benjamin Hänisch, Sofie L. Valk

Although empirical evidence shows that antidepressants are effective and superior to placebo in treating depressive disorders, their mechanisms of action are still unclear. In this study, we examine the multidimensional molecular affinities of 18 commonly used antidepressants. Clustering analyses consistently generate three …

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Whole-brain drug distribution profiles of psychedelic drugs provide insights into rapid antidepressant action

Benjamin Hänisch, Tobias Kaufmann, Sofie L. Valk

Recent studies pioneered the use of classic hallucinogens as Rapid-Acting Antidepressants (RAAD). To further understand the link between their neuromodulatory and antidepressant effects, we combine pharmacodynamic profiles of four classic hallucinogens and the anaesthetic Ketamine with receptor density distributions from both Positron …

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A Computational Perspective on Cognitive Behavioural Therapy

Benjamin Hänisch, Peter Dayan

Cognitive Behavioural Therapy (CBT) contains multiple conceptions about the origin, nature, and besttreatment of psychopathology. In this Review, we synthesise insights from the rich field of neuralreinforcement learning to develop a principled theoretical framework that encompasses the interventionsthat were developed within CBT’s …

Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers

Jeffrey Wang, Jung Min Suh, Brian Woo, Albertas Navickas et autres

From extrachromosomal DNA to neo-peptides, reprogramming of cancer genomes leads to the emergence of cancer state-specific molecules. Here, we systematically identify and characterize a large repertoire of orphan non-coding RNAs (oncRNAs), a class of cancer-emergent small RNAs, across 32 tumor types. We …

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690. The New Kid On The Block: Use of Maribavir in Pediatric Immunocompromised Hosts

Antigone Kraft, Madeline Johnson, Gabriela A. Marón, Diego R. Hijano et autres

Abstract Background Immunocompromised patients with Cytomegalovirus (CMV) infections may experience a variety of clinical syndromes ranging from graft dysfunction to death. Standard treatment options are often limited by end-organ toxicities and resistant/refractory CMV disease. Maribavir (MBV) is currently FDA-approved for the treatment …

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P-2113. Performance of a Commercial Metagenomic Microbial Cell-free DNA Sequencing Assay in Identifying Explanatory Pathogens of Pulmonary Nodules in a Multi-Center Pediatric Immunocompromised Population

Craig L K Boge, Brian T Fisher, Anna R. Huppler, MS Sarah Johnson et autres

Abstract Background Pulmonary nodules on radiography in setting of recent neutropenia or immune suppression for graft versus host disease (GVHD) are concerning for bacterial or invasive fungal disease (IFD). Determining etiology often requires invasive tests that may be inconclusive and pose risk. …

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691. Epidemiology of Viral Respiratory Infections in Pediatric Transplant: Initial results from the Viral Infections in Pediatric Transplant Recipients (VIPER) Study

Gabriela A. Marón, Sarah Longserre, Jose Ferrolino, Ronald H Dallas et autres

Abstract Background Respiratory viral infections (RVIs) cause substantial morbidity in pediatric transplant recipients. Previous efforts to establish the epidemiology of RVIs are mainly retrospective, with limited evaluation of association between pre-transplant screening of respiratory viruses and future RVIs. The VIPER study is …

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Cell-specific mechanisms drive connectivity across the time course of Huntington’s disease

Carlos Estevez‐Fraga, Isaac Sebenius, Justine Y. Hansen, Benjamin Hänisch et autres

Hyperconnectivity in functional brain networks occurs decades before disease onset in Huntington's disease. However, the biological mechanisms remain unknown. We investigate connectivity in Huntington's disease using Morphometric INverse Divergence (MIND) in three Huntington's disease cohorts (N = 512) spanning from two decades …

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Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers

Jeffrey Wang, Jung Min Suh, Brian J Woo, Albertas Navickas et autres

Abstract From extrachromosomal DNA to neo-peptides, the broad reprogramming of the cancer genome leads to the emergence of molecules that are specific to the cancer state. We recently described orphan non-coding RNAs (oncRNAs) as a class of cancer-specific small RNAs with the …

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Cerebral chemoarchitecture shares organizational traits with brain structure and function

Benjamin Hänisch, Justine Y. Hansen, Boris C. Bernhardt, Simon B. Eickhoff et autres

Chemoarchitecture, the heterogeneous distribution of neurotransmitter transporter and receptor molecules, is a relevant component of structure-function relationships in the human brain. Here, we studied the organization of the receptome, a measure of interareal chemoarchitectural similarity, derived from positron-emission tomography imaging studies of …

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Author response: Cerebral chemoarchitecture shares organizational traits with brain structure and function

Benjamin Hänisch, Justine Y. Hansen, Boris C. Bernhardt, Simon B. Eickhoff et autres

Chemoarchitecture, the heterogeneous distribution of neurotransmitter transporter and receptor molecules, is a relevant component of structure-function relationships in the human brain.Here, we studied the organization of the receptome, a measure of interareal chemoarchitectural similarity, derived from positron-emission tomography imaging studies of 19 …

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