Author response: Cerebral chemoarchitecture shares organizational traits with brain structure and function

Le résumé fourni par la source

Chemoarchitecture, the heterogeneous distribution of neurotransmitter transporter and receptor molecules, is a relevant component of structure-function relationships in the human brain.Here, we studied the organization of the receptome, a measure of interareal chemoarchitectural similarity, derived from positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors.Nonlinear dimensionality reduction revealed three main spatial gradients of cortical chemoarchitectural similarity -a centro-temporal gradient, an occipito-frontal gradient, and a temporo-occipital gradient.In subcortical nuclei, chemoarchitectural similarity distinguished functional communities and delineated a striato-thalamic axis.Overall, the cortical receptome shared key organizational traits with functional and structural brain anatomy, with node-level correspondence to functional, microstructural, and diffusion MRI-based measures decreasing along a primary-to-transmodal axis.Relative to primary and paralimbic regions, unimodal and heteromodal regions showed higher receptomic diversification, possibly supporting functional flexibility. Editor's evaluationThis work provides a valuable structural and functional characterization of the neurotransmitter's spatial distribution heterogeneity in cortical and subcortical regions.The authors report a systematic description and annotation of a new 'layer' of brain organization that has been relatively poorly integrated with the wider neuroimaging literature to date.In sum, this article has the potential to be of great interest to a wide audience in neurosciences.

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