Linda Sutherland

Redundancy of p75NTR neurotrophin receptor function in development, growth and fertility in the rat

Stephen E. Meek, Karamjit Singh Dolt, Linda Sutherland, Matthew G.F. Sharp et autres

Abstract The p75NTR neurotrophin receptor has positive and negative roles regulating cell survival in the nervous system. Unambiguous interpretation of p75NTR function in vivo has been complicated, however, by residual expression of alternate forms of p75NTR protein in initial p75NTR knock-out mouse …

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p75NTR neurotrophin receptor function is redundant for development, growth and fertility in the rat

Stephen E. Meek, Karamjit Singh Dolt, Linda Sutherland, Matthew G.F. Sharp et autres

Abstract The p75NTR neurotrophin receptor has positive and negative roles regulating cell survival in the nervous system. Unambiguous interpretation of p75NTR function in vivo has been complicated, however, by residual expression of alternate forms of p75NTR protein in initial p75NTR knock-out mouse …

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Patient Perceptions and Clinical Assessments of Cardiometabolic Disease After Subacute Spinal Cord Injury

Ryan J. Solinsky, Kevin Park, Luisa F. Betancourt, Mary Schmidt-Read et autres

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Stem cell-derived porcine macrophages as a new platform for studying host-pathogen interactions

Stephen E. Meek, Tom Watson, Lél Eöry, Gus R. McFarlane et autres

BACKGROUND: Infectious diseases of farmed and wild animals pose a recurrent threat to food security and human health. The macrophage, a key component of the innate immune system, is the first line of defence against many infectious agents and plays a major …

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Stem cell-derived macrophages as a new platform for studying host-pathogen interactions in livestock

Stephen E. Meek, Tom Watson, Lél Eöry, Gus R. McFarlane et autres

Abstract Infectious diseases of farmed and wild animals pose a recurrent threat to food security and human health. The macrophage, a key component of the innate immune system, is the first line of defence against many infectious agents and plays a major …

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Acute Spinal Cord Injury Is Associated With Prevalent Cardiometabolic Risk Factors

Ryan J. Solinsky, Luisa F. Betancourt, Mary Schmidt-Read, Mendel Kupfer et autres

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Hypoxanthine phosphoribosyltransferase (HPRT)‐deficiency is associated with impaired fertility in the female rat

Stephen E. Meek, Linda Sutherland, Jun Wei, Roger G. Sturmey et autres

The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites, and here we show that HPRT deficiency in the rat disrupts early …

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A Stem Cell Reporter for Investigating Pluripotency and Self-Renewal in the Rat

Stephen E. Meek, Jun Wei, Taeho Oh, Tom Watson et autres

Rat embryonic stem cells (rESCs) are capable of contributing to all differentiated tissues, including the germ line in chimeric animals, and represent a unique, authentic alternative to mouse embryonic stem cells for studying stem cell pluripotency and self-renewal. Here, we describe an …

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Correction: Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus

Clare Pridans, Anna Raper, Gemma M. Davis, Joana Alves et autres

In the analysis of gene expression in the brain, the sample labels for the pituitary gland and olfactory bulb were reversed. As a consequence, the clusters in Fig. 10B were mislabeled. A corrected version of Fig. 10 is shown below, along with …

Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus

Clare Pridans, Anna Raper, Gemma M. Davis, Joana Alves et autres

Abstract We have produced Csf1r-deficient rats by homologous recombination in embryonic stem cells. Consistent with the role of Csf1r in macrophage differentiation, there was a loss of peripheral blood monocytes, microglia in the brain, epidermal Langerhans cells, splenic marginal zone macrophages, bone-associated …

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LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein

Linda Sutherland, Madeleine Ruhe, Daniela Gattegno-Ho, Karanjit Mann et autres

The cytokine leukaemia inhibitory factor (LIF) promotes self-renewal of mouse embryonic stem cells (ESCs) through activation of the transcription factor Stat3. However, the contribution of other ancillary pathways stimulated by LIF in ESCs, such as the MAPK and PI3K pathways, is less …

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Atherosclerosis in contemporary preindustrial populations: does it exist and is it clinically relevant?

Michael Gurven, Benjamin C. Trumble, Jonathan Stieglitz, Bret Beheim et autres

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