Gregory J. Bancroft

Immune responses in beta-thalassaemia: heme oxygenase 1 reduces cytokine production and bactericidal activity of human leucocytes

Arnone Nithichanon, Inthira Tussakhon, Waraporn Samer, Chidchamai Kewcharoenwong et autres

Patients with beta-thalassaemia increase the risk of bacterial infections, particularly Burkholderia pseudomallei (Bp), the causative agent of melioidosis in Thailand. Impaired immune cell functions may be the cause of this susceptibility, but detailed mechanisms have not been defined. In this study, we …

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Glibenclamide alters interleukin-8 and interleukin-1β of primary human monocytes from diabetes patients against Mycobacterium tuberculosis infection

Chidchamai Kewcharoenwong, Wipawee Saenwongsa, Sam Willcocks, Gregory J. Bancroft et autres

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Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis

Florence Levillain, Hongmin Kim, Kee Woong Kwon, Simon O Clark et autres

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Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

Akul Singhania, Christine M. Graham, Leona Gabryšová, Lúcia Moreira-Teixeira et autres

Abstract Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we show a breadth of immune responses in …

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Oxidized Carbon Nanosphere-Based Subunit Vaccine Delivery System Elicited Robust Th1 and Cytotoxic T Cell Responses

Pritsana Sawutdeechaikul, Felipe Cia, Gregory J. Bancroft, Supason Pattanaargson Wanichwecharungruang et autres

(Mtb) proteins, Ag85B and HspX, into bone marrow derived macrophages (BMDMs) and dendritic cells (BMDCs) was investigated. For immunization, OCNs were mixed with the two TB antigens as well as the adjuvant monophosphoryl lipid A (MPL). The protective efficacy was analyzed in …

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Genome Resequencing of Laboratory Stocks of Burkholderia pseudomallei K96243

Sariqa Wagley, Andrew Scott, Philip M. Ireland, Joann L. Prior et autres

We have resequenced the genomes of four Burkholderia pseudomallei K96243 laboratory cultures and compared them to the reported genome sequence that was published in 2004. Compared with the reference genome, these laboratory cultures harbored up to 42 single-nucleotide variants and up to …

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Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization

Chidchamai Kewcharoenwong, Satria Adji Hady Prabowo, Gregory J. Bancroft, Helen A. Fletcher et autres

Tuberculosis (TB) is a global public health problem, which is caused by Mycobacterium tuberculosis (Mtb). Type 2 diabetes mellitus (T2DM) is one of the leading predisposing factors for development of TB after HIV/AIDS. Glibenclamide is a widely used anti-diabetic drug in low …

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Inactivation of bpsl1039-1040 ATP-binding cassette transporter reduces intracellular survival in macrophages, biofilm formation and virulence in the murine model of Burkholderia pseudomallei infection

Peechanika Pinweha, Pornpan Pumirat, Jon Cuccui, Niramol Jitprasutwit et autres

Burkholderia pseudomallei, a gram-negative intracellular bacillus, is the causative agent of a tropical infectious disease called melioidosis. Bacterial ATP-binding cassette (ABC) transporters import and export a variety of molecules across bacterial cell membranes. At present, their significance in B. pseudomallei pathogenesis is …

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Targeting intracellular Burkholderia by antibody and antibiotic combination therapies

Adam W. Taylor, Dominic C. Jenner, Gregory J. Bancroft, Caroline Ann Rowland et autres

The Sri Lankan Journal of Infectious Diseases (SLJID) is an open access, peer-reviewed, biannual journal published by the Sri Lankan Society for Microbiology (SSM). The Journal considers articles from all professional disciplines involved in the field of infectious diseases. The Journal has …

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Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?

Richard W. Titball, Mary N. Burtnick, Gregory J. Bancroft, Paul J. Brett

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A proteasome inhibitor produced by Burkholderia pseudomallei modulates intracellular growth

Sariqa Wagley, Muthita Vanaporn, Darawan Rinchai, Laura Conejero et autres

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Interleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei

Bianca Kessler, Darawan Rinchai, Chidchamai Kewcharoenwong, Arnone Nithichanon et autres

Abstract Melioidosis, caused by Burkholderia pseudomallei , is endemic in northeastern Thailand and Northern Australia. Severe septicemic melioidosis is associated with high levels of pro-inflammatory cytokines and is correlated with poor clinical outcomes. IL-10 is an immunoregulatory cytokine, which in other infections …

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