Supason Pattanaargson Wanichwecharungruang

Recent advances in coated and dissolving microneedle technologies for clinical translation

Supason Pattanaargson Wanichwecharungruang, Supanan Ampawa

INTRODUCTION: Despite decades of research, no FDA-approved coated or dissolving microneedles currently exist for therapeutics or vaccines. Clinical translation requires aligning biophysical delivery mechanisms with product-specific regulatory and biopharmaceutical standards. AREA COVERED: This review analyzes critical design bottlenecks, including the skin's elastic …

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Detachable hyaluronic acid tattoo microneedles of various colorants

Kornkamol Obthong, Supanan Ampawa, Supason Pattanaargson Wanichwecharungruang

Here, we used a detachable hyaluronic acid (HA) microneedle platform to deposit a diverse set of colorants into the skin. Microneedle patches with 1000 μm needle length were fabricated from high-molecular-weight HA (2000 kDa) and loaded with fifteen colorants, including three black …

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Bioactive‐Loaded Detachable Crosslinked Hyaluronic Acid Microneedles: Structural Validation and Clinical Anti‐Wrinkle Efficacy

Puttikorn Pukfukdee, Supanan Ampawa, Wirada Littirak, Supakij Suttiruengwong et autres

ABSTRACT Delivering a persistent biopolymer matrix to the superficial dermis remains a significant challenge for microneedle systems due to the inherent limitations of conventional dissolving platforms. Here, we present a detachable microneedle design that permits rapid needle separation during administration. To biologically …

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Thermoregulating fabrics from cellulose-silk fibroin blend fibers with discrete phase change material loading

Nichakan Miengmern, Warayuth Sajomsang, Supason Pattanaargson Wanichwecharungruang

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Engineering Detachable Hyaluronic Acid Microneedles for Controlled Intradermal Delivery of Particulate and Molecular Colorants: Influence of Matrix Cross-Linking and Particle Size

Kornkamol Obthong, Supanan Ampawa, Supason Pattanaargson Wanichwecharungruang

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Author response for "Composites of hyaluronic acid and various amino acids as structural materials for dissolvable microneedles"

Miranda Oungeun, Supason Pattanaargson Wanichwecharungruang

Detachable Microneedles With Crosslinked Hyaluronic Acid as Superficial Skin Filler

Pattrawadee Toprangkobsin, Apasinee Teepakakorn, Supanan Ampawa, Ahmad Efendi et autres

Crosslinking gives hyaluronic acid (HA) the ability to resist digestion by hyaluronidase; thus, crosslinked hyaluronic acid (cHA) is currently the most popular soft tissue filler. Clinically trained physicians usually administer cHA to the desired site via injections. Injection into the upper dermis …

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Botulinum Toxin-loaded Detachable Dissolvable Microneedles for Primary Axillary Hyperhidrosis: A Pilot Study on Efficacy and Safety.

Jidapa Triwatcharikorn, Kridipop Charoenchaipiyakul, Titiporn Sansureerungsikul, Nunthanach Chuenboonngarm et autres

Objective: Botulinum toxin injection is a well-established treatment for primary hyperhidrosis. The botulinum toxin-loaded detachable dissolvable microneedles (BoNT-MNs) were developed in a result of disadvantages of the intradermal procedure. This pilot study aims to evaluate the efficacy and safety of BoNT-MNs. Methods: …

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Cellulose Fibers Containing Discrete Phase Change Material for Thermoregulation

Nichakan Miengmern, Warayuth Sajomsang, Supason Pattanaargson Wanichwecharungruang

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Composites of hyaluronic acid and various amino acids as structural materials for dissolvable microneedles

Miranda Oungeun, Supason Pattanaargson Wanichwecharungruang

porcine skin well. Among these five AAs, only the hydrophilic ones-Arg, Thr, and Hyp-when combined with HA, significantly increase the rate of water solubility. The microneedles made from the composites of HA and each of these three AAs showed faster diffusion in …

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Detachable dissolvable microneedles maintain the viability of phage cocktail and effectively disrupt Pseudomonas aeruginosa biofilm

Ahmad Efendi, Ampapan Naknaen, Supanan Ampawa, Nichakan Miengmern et autres

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Seeing through the skin: Optical methods for visualizing transdermal drug delivery with microneedles

Benchaphorn Limcharoen, Supason Pattanaargson Wanichwecharungruang, Wijit Banlunara, Maxim E. Darvin

Optical methods play a pivotal role in advancing transdermal drug delivery research, particularly with the emergence of microneedle technology. This review presents a comprehensive analysis of optical methods used in studying transdermal drug delivery facilitated by microneedle technology. Beginning with an introduction …

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