Kee Woong Kwon

Type I IFN-induced viperin promotes Mycobacterium tuberculosis survival by suppressing the protective COX-2/PGE2/IL-1β axis in macrophages

Ju Mi Lee, Lee‐Han Kim, Jiyun Park, S.H. Choi et autres

Type I interferon (IFN) signaling is associated with detrimental outcomes during Mycobacterium tuberculosis (Mtb) infection, in part through antagonism of IL-1β-mediated protective immunity. Viperin, an IFN-stimulated gene induced downstream of type I IFN, has previously been implicated in suppressing innate immune responses …

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An ESAT-6-convergent prime-boost vaccination combining recombinant BCG expressing Mycobacterium marinum ESX-1 and ESAT-6/GLA-SE improves TB protection

Kee Woong Kwon, Hongmin Kim, Hagyu Kim, Roland Brosch et autres

Although Bacille Calmette-Guérin (BCG) protects children against disseminated tuberculosis (TB), its limited efficacy against adult pulmonary TB underscores the need for improved vaccination strategies. We previously developed a recombinant BCG strain expressing the ESX-1 type VII secretion system of Mycobacterium marinum (BCG::ESX-1Mmar), …

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Exploring Host-driven Immunopathological Factors Developing Severe Tuberculosis: Insights from Comparative Mouse Models

Hongmin Kim, Kee Woong Kwon, Hagyu Kim, WeonSeok Jung et autres

(Mtb). To elucidate host determinants of TB immunopathology, we conducted a comparative analysis of inbred mouse strains infected with the highly virulent Mtb K strain. Among the strains tested, C3H/HeJ and A/J mice exhibited markedly increased susceptibility, characterized by elevated pulmonary bacterial …

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Identification of Potential Gene Determinants Associated with Mouse Infectivity-Related Immune Modulation in Helicobacter pylori

Jong-Hun Ha, Jin-Sik Park, Jeong-Gyu Choi, Jeong-Ih Shin et autres

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Mycobacterium tuberculosis-specific T cells restrain anti-cancer drug-induced neutrophilic lung inflammation in tuberculosis

Kee Woong Kwon, Tae Gun Kang, Jii Bum Lee, Eunsol Sol Choi et autres

Cancers are a risk factor for active tuberculosis (TB), and anti-cancer drugs can independently cause TB progression. To understand the underlying mechanisms, mice infected with Mycobacterium tuberculosis (Mtb) were treated with gemcitabine (Gem), cisplatin, or paclitaxel. These treatments delay Mtb-specific T cell …

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Enhanced tuberculosis control via leveraging dendritic cell-mediated Th1 responses in preventive and immunotherapeutic vaccine strategies

Hongmin Kim, Jong-Seok Kim, Kee Woong Kwon, Woo Sik Kim et autres

Introduction Insufficient vaccine efficacy of the Bacillus Calmette-Guérin (BCG) and long, expensive tuberculosis (TB) treatments highlight the need for better TB control measures. Methods This study evaluated whether the adoptive transfer of dendritic cell (DC)-based vaccines pulsed with culture filtrate antigens (CFA) …

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Adjunctive beneficial effect of c-di-GMP, a STING agonist, in enhancing protective efficacy of TLR4-adjuvanted tuberculosis subunit vaccine formulations

Kee Woong Kwon, Eunsol Sol Choi, Hagyu Kim, Hyeong-Woo Kim et autres

Abstract Background Effective subunit vaccine development requires selecting appropriate adjuvant formulations to trigger desired adaptive immune responses. This study explores the immunogenicity and tuberculosis (TB) vaccine potential of antigens (Ags) combined with Toll-like receptor 4 (TLR4) adjuvants and a stimulator of interferon …

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Prevalence and virulence profiles of ESBL-producing Escherichia coli in urinary and blood infections in South Korea

Jong-Hun Ha, Jeong-Ih Shin, Kyu-Min Kim, Jeong-Gyu Choi et autres

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Clinical impact of major pathogenic genotypes of Pseudomonas aeruginosa associated with refractory chronic suppurative otitis media

Chang Hyeon Lee, Kyu-Min Kim, Jeong-Ih Shin, Da Min Jeong et autres

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Permissive lung neutrophils facilitate tuberculosis immunopathogenesis in male phagocyte NADPH oxidase-deficient mice

Eunsol Sol Choi, Hong‐Hee Choi, Kee Woong Kwon, Hagyu Kim et autres

NADPH oxidase 2 (NOX2) is an enzyme responsible for generating reactive oxygen species, primarily found in phagocytes. Chronic Granulomatous Disease (CGD), along with bacterial infections such as Mycobacterium tuberculosis (Mtb), is a representative NOX2-deficient X-linked disease characterized by uncontrolled inflammation. However, the …

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Adjunctive administration of parabiotic Lactobacillus sakei CVL-001 ameliorates drug-induced toxicity and pulmonary inflammation during antibiotic treatment for tuberculosis

Hagyu Kim, Eun-Jung Song, Eunsol Sol Choi, Kee Woong Kwon et autres

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BCG-booster vaccination with HSP90-ESAT-6-HspX-RipA multivalent subunit vaccine confers durable protection against hypervirulent Mtb in mice

Kee Woong Kwon, Han‐Gyu Choi, Kwang Sung Kim, Shin Ae Park et autres

Abstract The quest for effective and enhanced multiantigenic tuberculosis (TB) subunit vaccine necessitates the induction of a protective pathogen-specific immune response while circumventing detrimental inflammation within the lung milieu. In line with this goal, we engineered a modified iteration of the quadrivalent …

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