Jiawei Gui

Aldehyde dehydrogenase 9A1 promotes cisplatin resistance in laryngeal squamous cell carcinoma by enhancing PTEN-induced kinase 1–Parkin-mediated mitophagy

Jiawei Gui, Bo Wu, Yuhua Fan, Xiaotong Liu et autres

Cisplatin resistance remains a major challenge in laryngeal squamous cell carcinoma (LSCC) treatment. Aldehyde dehydrogenase 9A1 (ALDH9A1), a mitochondrial matrix protein, is dysregulated in various cancers, but its role in LSCC is unclear. This study demonstrates that ALDH9A1 is significantly downregulated in …

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ABCC2 as a drug target for post-stroke recovery: Evidence from Mendelian randomization and colocalization analyses

Jiawei Gui, Zhiwen Qi, Keqi Wan, Xiangli Dong et autres

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Specific signaling pathways mediated programmed cell death in tumor microenvironment and target therapies

Cheng‐Peng Sun, Jiawei Gui, Yilei Sheng, Le Huang et autres

Increasing evidence has shown that programmed cell death (PCD) plays a crucial role in tumorigenesis and cancer progression. The components of PCD are complex and include various mechanisms such as apoptosis, necroptosis, alkaliptosis, oxeiptosis, and anoikis, all of which are interrelated in …

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Comparative analysis of tissue damage and inflammatory response for transoral laser microsurgery versus open surgery in the management of early-stage laryngeal cancer

Jingchun Ge, Jiawei Gui, Hui Faye Xiao

OBJECTIVE: This study aimed to analyze the perioperative dynamic changes of tissue damage and inflammatory response markers, and to determine whether these differ between transoral laser microsurgery (TLM) and open surgery (OS) in early-stage laryngeal cancer. METHODS: In a randomized controlled study …

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Identification of TAP2 as a novel immune target in human cancers: insights from integrated bioinformatics and experimental approaches

Lufei Yang, Jiawei Gui, Yilei Sheng, Junzhe Liu et autres

BACKGROUND: Transporter 2, ATP binding cassette (ABC) subfamily B member (TAP2), encodes a protein within the ABC transporter superfamily. TAP2 plays a role in the progression of cancers, such as cervical, breast, and lung cancers. However, the relationship between TAP2 and cancer …

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[Evaluation of arthroscopic anterior talofibular ligament and calcaneofibular ligament repair separately for chronic lateral ankle instability in conjunction with subtalar instability].

Weiwei Mao, Jingyan Tang, Yong Zhang, Wei Li et autres

Arthroscopically repairing the ATFL and CFL separately can effectively restore the stability of the ankle and subtalar joint with small trauma. Patients can recover quickly after surgery. It provides a new idea for the clinical treatment of CLAI combined with STI.

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Visual trends and hot research on the relationship between intestinal microbiota and major lipids: a bibliometric analysis

Weiming Sun, Keqi Wan, Jiawei Gui, Guoqiang Jin et autres

Objective: The association between intestinal microbiota and lipids has garnered significant scholarly interest. This study analyzes pertinent literature on intestinal microbiota and lipids to offer scientific guidance for future advancements and research directions. Methods: Articles focusing on intestinal microbiota and lipids were …

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Causal effects of immune cell surface antigens and functional outcome after ischemic stroke: a Mendelian randomization study

Weiming Sun, Jiawei Gui, Keqi Wan, Yize Cai et autres

Objective: While observational studies link immune cells with post-stroke functional outcome, the underlying immune mechanisms are not well understood. Immune cell surface antigens are actively involved in the biological behavior of immune cells, investigating immune cell surface antigens could deepen our comprehension …

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[Resveratrol protects dopaminergic neurons in a mouse model of Parkinson's disease by regulating the gut-brain axis via inhibiting the TLR4 signaling pathway].

Jiawei Gui, Xiaoguang Sun, Shenglin Wen, Xinyao Liu et autres

OBJECTIVE: To investigate the protective effect of resveratrol on intestinal barrier in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mouse models and its mechanism for regulating TLR4/MyD88/NF-κB signaling to protect dopaminergic neurons. METHODS: -syn, ZO-1, Claudin-1, TLR4, MyD88, and NF-κB in …

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Identifying the prognosis implication, immunotherapy response prediction value, and potential targeted compound inhibitors of integrin subunit α3 (ITGA3) in human cancers

Jiawei Gui, Lufei Yang, Junzhe Liu, Yishuang Li et autres

The integrin subunit α3 (ITGA3) is a member of the integrin alpha chain protein family, which could promote progression, metastasis, and invasion in some cancers. Still, its function in the tumor microenvironment (TME), cancer prognosis, and immunotherapy remains unclear. A multifaceted analysis …

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Aldha91 Promoting Mitophagy and Leads to Cisplatin Resistance in Laryngeal Cancer Through Inhibits Parl-Induced Pink1 Degradation

Jiawei Gui, Bo Wu, Xiaotong Liu, Yuzhe Liu et autres

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Prognostic Value of Platelet Aggregation Function in Patients with laryngeal Carcinoma

Ming‐Hua Li, Jiawei Gui, Hao Wang, Jun An et autres

Background: Laryngeal cancer was one of the most common malignancies of the head in those years. It has become one of the most common causes of death due to its high recurrence rate and high metastasis rate. It was well known that …

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