Cheng‐Peng Sun

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Juan Zhang, Xin-Rong Xu, Huilin Zhang, Qi-Meng Zhu et autres

ABSTRACT Inflammatory bowel disease (IBD) is characterized by chronic relapsing intestinal inflammation and closely associated with persistent inflammatory responses and impairment of the mucosal barrier integrity. In this work, we demonstrated that Th17/Treg immune imbalance drove inflammation and pyroptosis in IBD, as …

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Targeting eEF1A1 With Baicalein to Block eEF1A1/Prdx4 Interaction for Treating Sepsis‐Mediated Lung Injury

Jing Chang, Huilin Zhang, Qi-Meng Zhu, Si-Wen Hui et autres

ABSTRACT Sepsis is a systemic inflammatory response syndrome triggered by an uncontrolled host response to infection, which causes acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Baicalein (Bai) is one of the major active components of Scutellariae Radix for treating …

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Reduning injection alleviated LPS-induced ARDS via multi-target regulation by modulating inflammation and immune responses based on target fishing technique and scRNA-seq analysis

Si-Wen Hui, Qi-Meng Zhu, Zi-zhou Liu, Xin-Rong Xu et autres

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Chemiluminescent optical fiber sensor with in-situ terminal deoxynucleotidyl transferase-catalyzed polymerization for trace glycoprotein analysis in point-of-care setting

Yaxue Jia, Cheng‐Peng Sun, Jing Huang, Jinlan Yang et autres

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Bioactive constituents from Inula japonica as soluble epoxide hydrolase inhibitors: Mechanistic insights and anti-neuroinflammatory potentials

Na Wang, Ya-Xue Jia, Xinrong Xu, Jing Chang et autres

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Dimeric sesquiterpenoids with anti-inflammatory activities from Inula britannica

Juan Zhang, Jian‐Kun Yan, Hongjun Dong, Rui Zhang et autres

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Site-specific cleavage-based fluorescence sensing strategy for imaging thioredoxin reductase in living cells and tissues

Ya-Xue Jia, Na Wang, Juan Zhang, Cheng‐Peng Sun

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Targeting PBK with small-molecule 1- O -acetyl-4 R ,6 S -britannilactone for the treatment of neuroinflammation

Juan Zhang, Huilin Zhang, Xin-Rong Xu, Yanli Feng et autres

Neuroinflammation is a complex immunological phenomenon characterized by a dysregulated inflammatory response in the central nervous system (CNS) that can be triggered by various pathological injuries, such as toxins, which are involved in Parkinson’s and Alzheimer’s diseases (PD and AD), therefore, suppressing …

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Ferroptosis: a double-edged sword that enhances radiation sensitivity and facilitates radiation-induced injury in tumors

Yang Liu, Jianhao Zhan, Jisheng Wang, Xiaoping Zeng et autres

Cell death is a crucial mechanism by which radiotherapy eliminates tumor cells. Ferroptosis, characterized by intracellular iron overload and lipid peroxidation, represents a distinct form of programmed cell death. Recent research has demonstrated that numerous malignant tumors exhibit high sensitivity to ferroptosis. …

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Andrographolide and its sulfated metabolite alleviated DSS-induced inflammatory bowel disease through regulating inflammation and immune via MAPK/NLRP3 pathways and the balance of Th17/Treg cells

Huilin Zhang, Jing Chang, Cheng‐Peng Sun, Zhipeng Huo et autres

Inflammatory Bowel Disease (IBD), is a chronic illness characterized by severe abdominal pain, diarrhea, and weight loss, seriously diminishing patients' quality of life. Andrographolide (AND), a natural diterpenoid from Andrographis paniculata, and its sulfated metabolite, andrographolide sodium bisulfite (ASB), have showed potential …

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Specific signaling pathways mediated programmed cell death in tumor microenvironment and target therapies

Cheng‐Peng Sun, Jiawei Gui, Yilei Sheng, Le Huang et autres

Increasing evidence has shown that programmed cell death (PCD) plays a crucial role in tumorigenesis and cancer progression. The components of PCD are complex and include various mechanisms such as apoptosis, necroptosis, alkaliptosis, oxeiptosis, and anoikis, all of which are interrelated in …

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Corrigendum: A new weapon: the application of tumor vaccines based on extracellular exosomal heat shock proteins in immunotherapy

Kexin Yi, Cheng‐Peng Sun, Zhen Luo, Hongliang Luo

Frontiers Corrigendum Template for AuthorsA corrigendum refers to a change to their article that the author wishes to publish after publication. The publication of this article is subject to Frontiers Editorial approval.There was a mistake in the Author affiliation and the order …

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