Lufei Yang

Telomere length in leukocyte as biomarker for diagnosis of primary Sjögren’s syndrome: a cross-sectional study

Han Fang, Ronglin Gao, Haohui Fan, Jincheng Pu et autres

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Clathrin mediated endocytosis targeting chimera for targeted membrane proteins degradation and enhance CAR-T cell anti-tumor therapy

Yishuang Li, Zhihong Zhou, Yonghui Lv, H. M. Hu et autres

Rationale: T cell exhaustion, mediated by the expression of inhibitory receptor proteins, significantly reduces their anti-tumor efficacy.Therefore, strategies aimed at degrading membrane proteins have emerged as promising approaches for enhancing the therapeutic effectiveness of Chimeric Antigen Receptor (CAR) T cells and improving …

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ZrB2/MgAl2O4 ceramic with embedded BN interface for improved electromagnetic wave absorption at elevated temperature

Lufei Yang, Yuheng Liu, Ting Chen, Zhengyi Fu et autres

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Synergistic multiple microwave attenuation of ZrB2@BN composites as thin and efficient microwave absorbing materials

Lufei Yang, Ting Chen, Yuheng Liu, Jie Wang et autres

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Identification of TAP2 as a novel immune target in human cancers: insights from integrated bioinformatics and experimental approaches

Lufei Yang, Jiawei Gui, Yilei Sheng, Junzhe Liu et autres

BACKGROUND: Transporter 2, ATP binding cassette (ABC) subfamily B member (TAP2), encodes a protein within the ABC transporter superfamily. TAP2 plays a role in the progression of cancers, such as cervical, breast, and lung cancers. However, the relationship between TAP2 and cancer …

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Lipid Metabolism: An Emerging Player in Sjögren’s Syndrome

Keni Chang, Peiming Luo, Zizhen Guo, Lufei Yang et autres

Sjögren's syndrome (SS) is a chronic autoimmune disorder that primarily affects the exocrine glands. Due to the intricate nature of the disease progression, the exact mechanisms underlying SS are not completely understood. Recent research has highlighted the complex interplay between immune dysregulation …

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FBXL16 Downregulation in Glioblastoma Enhances CNN3-Mediated Protection of Phospho-ERK1/2

Zhansheng Fang, Jingying Li, Junzhe Liu, Kunjian Lei et autres

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Connecting the Dots: Telomere Shortening and Rheumatic Diseases

Fang Han, Farooq Riaz, Jincheng Pu, Ronglin Gao et autres

Telomeres, repetitive sequences located at the extremities of chromosomes, play a pivotal role in sustaining chromosomal stability. Telomerase is a complex enzyme that can elongate telomeres by appending telomeric repeats to chromosome ends and acts as a critical factor in telomere dynamics. …

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Dysregulated serum lipid profile is associated with inflammation and disease activity in primary Sjögren's syndrome: a retrospective study in China

Lufei Yang, Yuanyuan Liang, Jincheng Pu, Li Cai et autres

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Functional significance of DNA methylation: epigenetic insights into Sjögren’s syndrome

Yanqing Wang, Farooq Riaz, Jincheng Pu, Yuanyuan Liang et autres

Sjögren's syndrome (SjS) is a systemic, highly diverse, and chronic autoimmune disease with a significant global prevalence. It is a complex condition that requires careful management and monitoring. Recent research indicates that epigenetic mechanisms contribute to the pathophysiology of SjS by modulating …

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The link between neutrophils, NETs, and NLRP3 inflammasomes: The dual effect of CD177 and its therapeutic potential in acute respiratory distress syndrome/acute lung injury

Jingying Li, Zhansheng Fang, Shumin Xu, Haiwei Rao et autres

Neutrophils are important inflammatory effector cells that protect against foreign invasion but also cause self-harm. Numerous neutrophils infiltrate the lungs in acute respiratory distress syndrome/acute lung injury (ARDS/ALI) patients. However, the exact impact of neutrophil infiltration on ARDS's onset and progression remains …

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Identifying the prognosis implication, immunotherapy response prediction value, and potential targeted compound inhibitors of integrin subunit α3 (ITGA3) in human cancers

Jiawei Gui, Lufei Yang, Junzhe Liu, Yishuang Li et autres

The integrin subunit α3 (ITGA3) is a member of the integrin alpha chain protein family, which could promote progression, metastasis, and invasion in some cancers. Still, its function in the tumor microenvironment (TME), cancer prognosis, and immunotherapy remains unclear. A multifaceted analysis …

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