Prognostic Value of Platelet Aggregation Function in Patients with laryngeal Carcinoma
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Le résumé fourni par la source
Background: Laryngeal cancer was one of the most common malignancies of the head in those years. It has become one of the most common causes of death due to its high recurrence rate and high metastasis rate. It was well known that platelets, especially activated platelets, promote the proliferation, division, and invasion of tumor cells. Activated platelets promote cancer progression and metastasis. However, the prognostic value of platelet aggregation function in laryngeal cancer remains poorly understood. The purpose of this study was to investigate the predictive significance of platelet aggregation function in laryngeal cancer. Materials and Methods: Between January 2015 and December 2016, we conducted a retrospective analysis of 203 patients who were diagnosed with laryngeal cancer consecutively. The patients were stratified by platelet aggregation function into two groups: low "adenosine diphosphate induced light transmittance aggregometry (ADP-induced LTA) ≤15.1" and high (ADP-induced LTA >15.1). Pathological tissues from different parts of the operation were collected and the pathologist determined the pathological type. We assessed the prognostic significance of platelet aggregation function using Kaplan-Meier curves and Cox regression. Results: The low cohort had a significantly higher lymphocyte count than the high cohort. Compared with the high cohort, the low cohort had significantly lower levels of platelet-to-lymphocyte ratio (PLR), ADP-induced LTA, and Interleukins (IL)-6. The ADP-induced LTA (hazard ratio, 1.212; P <0.001) was independently related with 5-year overall survival rate. Conclusion: Patients with ADP-induced LTA >15.1 experience poor outcomes. Platelet aggregation function, when elevated, could be a new prognostic indicator for laryngeal cancer.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prognostic Value of Platelet Aggregation Function in Patients with laryngeal Carcinoma
- Date Crossref
- 01/11/2023
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Harbin Medical University Department of Otolaryngology-Head and Neck Surgery pays non établi dans la noticeUniversité ou école supérieure
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Second Affiliated Hospital of Harbin Medical University pays non établi dans la noticeÉtablissement de santé
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Second Affiliated Hospital of Nanjing Medical University pays non établi dans la noticeÉtablissement de santé
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Nanjing Medical University Department of Otolaryngology-Head and Neck Surgery pays non établi dans la noticeUniversité ou école supérieure
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Xuzhou Central Hospital pays non établi dans la noticeÉtablissement de santé
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Department of Otolaryngology-Head and Neck Surgery pays non établi dans la noticeOrganisation à but non lucratif
Department of Otolaryngology-Head and Neck Surgery — Harbin Medical University, Second Affiliated Hospital of Harbin Medical University et Second Affiliated Hospital of Nanjing Medical University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.