Qing Xia Fan

L-serine dose-dependently ameliorates high-selenium-induced insulin resistance in mice

Shuo Zhan, Qin Wang, Yiqun Liu, Han Feng et autres

cn (code pays fourni par la source)

Efficacy and safety ranking of endoscopic resection techniques for colorectal polyps: a systematic review and network meta-analysis

Shirui Li, Yue Lei, Yunfan Deng, Sheng Long Dai et autres

Background: The rapid evolution of endoscopic resection techniques for colorectal polyps has created a diverse but fragmented evidence base, making it challenging to determine the technique that optimally balances efficacy and safety. Objectives: To comprehensively compare the efficacy and safety of all …

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Crosstalk between ferroptosis and extracellular vesicles in cancer: from interaction to clinical application

Jingyi Liu, Kewei Wang, Zhixiong Hao, Qing Xia Fan et autres

Cancer continues to pose a significant issue to public health. Despite the considerable advancements in popular therapies such as surgery, radiation, chemotherapy, targeted therapy, and immunotherapy, a substantial number of patients continue to suffer from cancer due to severe treatment resistance. As …

cn (code pays fourni par la source)

Phase Ib/II study of fruquintinib combined with SOX and toripalimab in advanced metastatic gastric/gastroesophageal junction adenocarcinoma (GC/GEJC).

X. Meng, Zhengzheng Shan, Lulu Guan, Xin Dao et autres

369 Background: There is an unmet need to improve the efficacy of first-line treatment in advanced GC/GEJC pts with negative or low PD-L1 expression. This Ib/II, open-label study (NCT05024812) aimed to identify the efficacy and safety of fruquintinib (VEGFR-1, -2, -3 inhibitor) …

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A Dual-Parallel Nanoplatform Integrating Substrate Sensitization and Oxidative Amplification for Ferroptosis Therapy in Colorectal Cancer

Furong Liu, Yifan Wu, Xin Jiang, Hongyu Ding et autres

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A GSH-responsive drug delivery system based on self-assembly of polyoxometalates modified camptothecin for chemotherapy

Lingmei Li, Shuwan Li, Lin Gao, Sitong Chen et autres

Amphiphilic self-assembly bridges nanoscale engineering with biological functionality, forming compartmentalized nanocarriers that enable stimuli-responsive drug delivery. We engineered a glutathione (GSH)-responsive amphiphilic conjugate (POMs-SS-CPT) by covalently linking hydrophilic polyoxometalates (POMs) with hydrophobic drug camptothecin (CPT) through disulfide bonds, alongside a non-responsive carbon-bonded …

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Engineered PD-L1-targeted multifunctional proteins with self-prolonged circulation for enhanced tumor photothermal-immunotherapy

Shiqi Zhao, Dianlong Jia, Xiaoyun Qi, Xin Xiao Bian et autres

ABSTRACT In this study, a novel Immunoglobulin G (IgG) binding, Programmed Cell Death-Ligand 1 (PD-L1) targeting affibody, IgBD-Z PD-L1 , was constructed by genetically fusing the PD-L1-specific affibody ZM1 with the IgG-binding domain (IgBD). IgBD-Z PD-L1 could simultaneously bind to IgG, PD-L1 …

cn (code pays fourni par la source)

Ultrasensitive Detection of m 6 A-Modified RNA Using CRISPR/Cas12a-Integrated Iontronic Biosensor with Hydrophobized Nanochannels: Toward Early Cancer Diagnosis by Machine Learning

Zhong Feng Gao, Xiaochen Yang, Xiang Zhong Ren, Hongmin Ma et autres

N 6 -methyladenosine (m 6 A), the most prevalent internal modification in eukaryotic RNAs, has emerged as a focal point of intensive research in recent years owing to its pivotal regulatory roles in carcinogenesis, progression, and metastasis. However, conventional methods for site-specific …

cn, gb, jp, us (code pays fourni par la source)

A novel EGFR-targeted photosensitizer for the theranostics of skin cancer

Huijuan Li, Huijun Li, Shuang Qi, Xiaohui Tang et autres

The epidermal growth factor receptor (EGFR) is a critical therapeutic target implicated in the pathogenesis and progression of skin cancer, holding significant promise for enhancing precision diagnosis and treatment efficacy. In this study, we developed ICG-Z EGFR , a novel EGFR-targeting agent …

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Engineered Magnetic Resonance Nanoprobes for Visualizing Tumor Programmed Cell Death Ligand 1 Level and Enhancing Synergistic Radio Immunotherapy

Xiao Jun Sun, Yufang Gong, Haiyan Ge, Guiqi Ma et autres

Visualizing tumor programmed cell death ligand 1 (PD-L1) expression and synchronously using this target for effective tumor therapy present great prospects for clinical application. In this study, a gadolinium-hybridized platinum nanoplatform with dimeric PD-L1-antagonistic affibody (Z PD-L1 ) (GPPZ) was constructed. Leveraging …

gb, cn, cz, de (code pays fourni par la source)

219. PATHOLOGICAL NETWORKING OF GRAY MATTER DENDRITIC DENSITY WITH CLASSIC BRAIN MORPHOMETRIES IN OCD

Xiaochen Zhang, Jiajia Zhou, Yongjun Chen, Lei Guo et autres

Abstract Background The pathogenesis of obsessive-compulsive disorder (OCD) may involve altered dendritic morphology, but in vivo imaging of neurite morphology in OCD remains limited. Such changes must be interpreted functionally within the context of the multimodal neuroimaging approach to OCD. Aims & …

cn, gb, pt (code pays fourni par la source)

402. THE EFFICACY OF DEEP BRAIN STIMULATION OF COMBINED ANTERIOR LIMB OF INTERNAL CAPSULE AND NUCLEUS ACCUMBENS FOR TREATMENT-REFRACTORY OBSESSIVE-COMPULSIVE DISORDER: A RANDOMISED, DOUBLE-BLINDED, AND SHAM-CONTROLLED STUDY

Jian Cheng, Hu Han, Qing Xia Fan, Kaiming Zhuo et autres

Abstract Background OCD is a treatment-resistant mental disorder, with a significant portion of patients not responding to first-line treatments. Deep brain stimulation (DBS) has emerged as a promising therapeutic approach for treatment-refractory OCD. Aims & Objectives We assessed the efficacy and safety …

cn (code pays fourni par la source)