Shuang Qi

H2AC19 promotes lung adenocarcinoma progression via p300/EGR1/MMP-1-mediated angiogenesis

Fuwen Zuo, Jinlong Yu, Tong Liu, X W Liu et autres

Angiogenesis is a hallmark of lung adenocarcinoma (LUAD) and a leading cause of mortality. Identifying potential therapeutic targets that modulate this process is of critical clinical importance. Here, we established a 12-gene risk-scoring model through bioinformatics screening and systematically delineated the molecular …

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A novel EGFR-targeted photosensitizer for the theranostics of skin cancer

Huijuan Li, Huijun Li, Shuang Qi, Xiaohui Tang et autres

The epidermal growth factor receptor (EGFR) is a critical therapeutic target implicated in the pathogenesis and progression of skin cancer, holding significant promise for enhancing precision diagnosis and treatment efficacy. In this study, we developed ICG-Z EGFR , a novel EGFR-targeting agent …

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Discovery of IHMT-15130 as a Highly Potent Irreversible BMX Inhibitor for the Treatment of Myocardial Hypertrophy and Remodeling

Shuang Qi, Jiangyan Cao, Ting Hua Wu, Chenliang Shi et autres

Cardiac hypertrophy is usually accompanied by many forms of heart disease, including hypertension, vascular disease, ischemic disease, and heart failure, and thus effectively predicts the increased cardiovascular morbidity and mortality. Bone marrow kinase in chromosome X (BMX) has been reported to be …

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Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation

Yan Li, Shuang Qi, Chao Wu, Rui Jin et autres

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A supramolecular ratiometric fluorescent probe for the detection of human serum albumin

Xue Liu, Shuang Qi, Jingyao Mao, Yuteng Zhang et autres

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Metabolite interactions between host and microbiota during health and disease: Which feeds the other?

Yan Zhang, Rui Chen, DuoDuo Zhang, Shuang Qi et autres

Metabolites produced by the host and microbiota play a crucial role in how human bodies develop and remain healthy. Most of these metabolites are produced by microbiota and hosts in the digestive tract. Metabolites in the gut have important roles in energy …

hk, cn (code pays fourni par la source)

Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatment

Aoli Wang, Juan Liu, Xixiang Li, Fengming Zou et autres

Abstract Although RAS mutations occur in about 30% of solid tumors, targeting RAS mutations other than KRAS-G12C is still challenging. As an alternative approach, developing inhibitors targeting RAF, the downstream effector of RAS signaling, is currently one of the main strategies for …

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Metabolites as extracellular vesicle cargo in health, cancer, pleural effusion, and cardiovascular diseases: An emerging field of study to diagnostic and therapeutic purposes

Yan Zhang, Feng Liang, DuoDuo Zhang, Shuang Qi et autres

Extracellular vesicles (EVs) are highly diverse nanoscale membrane-bound structures released from different cell types into the extracellular environment. They play essential functions in cell signaling by transporting their cargo, such as proteins, RNA, DNA, lipids, metabolites, and small molecules, to recipient cells. …

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Discovery of (E)-N-(4-methyl-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide (IHMT-TRK-284) as a novel orally available type II TRK kinase inhibitor capable of overcoming multiple resistant mutants

Beilei Wang, Wentao Zhang, Xuesong Liu, Fengming Zou et autres

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Identifying the Biomarkers of Spinal Cord Injury and the effects of Neurotrophin-3 Based on MicroRNA and mRNA Signature

Shuang Qi, Zinan Li, Shanshan Yu

Abstract Background To gain a better understanding of the molecular mechanisms of spinal cord injury and the effects of Neurotrophin-3, differentially expressed microRNAs (DEmiRNAs) and genes (DEGs) were analyzed. Methods The miRNA transcription profile of GSE82195 and the mRNA transcription profile of …

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Spatial Heterogeneous of Ecological Vulnerability in Arid and Semi-Arid Area: A Case of the Ningxia Hui Autonomous Region, China

Rong Ping Li, Rui Han, Qianru Yu, Shuang Qi et autres

Ecological vulnerability, as an important evaluation method reflecting regional ecological status and the degree of stability, is the key content in global change and sustainable development. Most studies mainly focus on changes of ecological vulnerability concerning the temporal trend, but rarely take …

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Application of textbooks to cultivate students' intuitive imagination literacy

Shuang Qi, Hui Gao, Zezhong Yang