Lingmei Li

Extracapsular Nodal Extension as a Key Prognostic Factor in FIGO IIIC Endometrial Carcinoma: A Clinic–Pathologic and Molecular Analysis

Lingmei Li, Changyu Geng, Ningrui Feng, Shi Zhang et autres

Background: Assessment of lymph node involvement was incorporated into the 2023 International Federation of Gynecology and Obstetrics (FIGO) staging system as a critical determinant of patient management and prognostication. This study aims to validate the prognostic significance of metastatic lymph node characteristics …

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Mass Spectrometric Analysis of N-Glycome of Patatin Proteins from Three Potato Cultivars

Lingmei Li, Sidi Luo, You Wu, Yajuan Zhou et autres

As a vital post-translational modification of potato tuber proteins, N-glycosylation directly regulates protein structural stability, biological activity and processing properties. N-glycome profiles of tuber storage proteins exhibit cultivar-specific characteristics, but the differential glycosylation across potato germplasms has not been fully elucidated. In …

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CAMK2D isoform 15 facilitates gefitinib resistance via AKT phosphorylation in lung adenocarcinoma

Lingmei Li, Danyang Ren, Yutian Wang, Jiaojiao Zhang et autres

Objective: Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is a major challenge in the treatment of lung adenocarcinoma (LUAD). Our previous study demonstrated that EGFR signaling activates calcium/calmodulin-dependent protein kinase 2 (CAMK2). However, the relationship between this mechanism …

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Lactylation in cardiac repair: Nexus and therapeutic opportunity

Fan Guo, Lingmei Li, Shujuan Xu, Li Li et autres

Lactylation is a lactate-driven post-translational modification that directly modifies lysine residues on both histone and non-histone proteins, thereby linking energy metabolism to epigenetic regulation. Its levels are dynamically orchestrated by intracellular lactate availability, as well as by specific lactyltransferases and delactylases, including …

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A GSH-responsive drug delivery system based on self-assembly of polyoxometalates modified camptothecin for chemotherapy

Lingmei Li, Shuwan Li, Lin Gao, Sitong Chen et autres

Amphiphilic self-assembly bridges nanoscale engineering with biological functionality, forming compartmentalized nanocarriers that enable stimuli-responsive drug delivery. We engineered a glutathione (GSH)-responsive amphiphilic conjugate (POMs-SS-CPT) by covalently linking hydrophilic polyoxometalates (POMs) with hydrophobic drug camptothecin (CPT) through disulfide bonds, alongside a non-responsive carbon-bonded …

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Monitoring of Flutamide as Anti-Cancer Drug in the management and treatment of prostate cancer: A photocatalytic study

Lingmei Li, Li Xiong

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Magneto-dielectrophoretic separation of circulating tumor cells

Lingmei Li, Zongshan Pu

Mass Spectrometric Analysis of Antigenic Determinant Glycans of Soybean Glycoprotein Gly m Bd 30K

Lingmei Li, You Wu, Yuxin Ding, Yajuan Zhou

Glycosylation of many proteins has been revealed to be closely related to food allergy, and screening and structural analysis of related glycoproteins are essential for studies in this important area. Gly m Bd 30K is one of the major allergens that exist …

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Recent progress in antimicrobial activity, mechanism, and application of polyoxometalate and its hybrid composites

Wen-Bin Zhao, Xiaoying Lü, Lingmei Li, Jiacheng Wu et autres

Abstract Bacterial infections, as a global public health problem, are a serious threat to human life and health safety with the significant increase of antibiotic‐resistant bacteria. Polyoxometalates (POMs), with their unique structure, and high biocompatibility and designability, have received widespread attention in …

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Corrigendum to “Shuangshen ningxin formula attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial function” [J. Ethnopharmacol. 323 (2024) 117690]

ZiXin Liu, Xiao Han, Yue You, Gaojie Xin et autres

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Clinicopathological characteristics and prognostic significance of HER2 status evaluation in patients with urothelial carcinoma: a retrospective single-center experience in China

Manlin Yang, Ye Yao, Kun Wang, Lisha Qi et autres

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Development of a deep learning system for predicting biochemical recurrence in prostate cancer

Lu Cao, Ruimin He, Ao Zhang, Lingmei Li et autres

BACKGROUND: Biochemical recurrence (BCR) occurs in 20%-40% of men with prostate cancer (PCa) who undergo radical prostatectomy. Predicting which patients will experience BCR in advance helps in formulating more targeted prostatectomy procedures. However, current preoperative recurrence prediction mainly relies on the use …

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