Yuto Kamitaka

Consistency assessment of voxel dosimetry using a Monte Carlo dose engine implemented in the updated MIM SurePlan™ MRT for 177Lu-DOTATATE therapy

Kenta Miwa, Kaito Wachi, David Mirando, Arata Komatsu et autres

ABSTRACT Background Patient-specific dosimetry for targeted radionuclide therapy (TRT) requires accurate estimation of three-dimensional absorbed dose distributions because radiopharmaceutical uptake and tissue density vary substantially within and between organs and tumors. A Monte Carlo (MC)-based dose engine has recently been implemented in …

jp (code pays fourni par la source)

Comparison of alpha-particle track characteristics in GAGG and biological tissues for microdosimetry using experimentally validated GATE simulations with high-resolution track imaging

Kohei Nakanishi, Seiichi Yamamoto, Masao Yoshino, Yuto Kamitaka et autres

Abstract Objective. Real-time imaging of alpha-particle tracks in scintillators is promising for microdosimetric studies of alpha-emitting radionuclides in targeted radionuclide therapy. However, when inorganic scintillators such as Gd 3 Al 2 Ga 3 O 12 (GAGG) are used, the observed track characteristics …

jp (code pays fourni par la source)

14. The Role of Radiological Technology Science in Targeted Radionuclide Therapy: Integrating Radiation Safety, Quantitative Imaging, and Dosimetry

Kenta Miwa, Noriaki Miyaji, Tensho Yamao, Masaki Masubuchi et autres

jp, us (code pays fourni par la source)

First-in-human PET study of [18F]FSW-100 for imaging histone deacetylase 6 in the brain: safety, biodistribution, radiation dosimetry, and brain kinetic analyses

Tetsuro Tago, Muneyuki Sakata, Yuto Kamitaka, Masashi Kameyama et autres

Histone deacetylase 6 (HDAC6) is a lysine deacetylase that modulates protein function and turnover, and is critically implicated in the pathogenesis of neurodegenerative disorders. [ 18 F]FSW-100 is a promising radioligand designed to enable visualization of HDAC6 in the brain. In this …

jp (code pays fourni par la source)

Astrocyte reactivity across the AD continuum measured by [18F]SMBT-1 and its relationship with the Aβ burden

Yingying Wu, Kotaro Hiraoka, Berihu Mesfin, Asuka Kikuchi et autres

Abstract Purpose Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer’s disease (AD) brain tissue; however, their spatiotemporal dynamics in vivo remain poorly understood. This multicenter study aimed to investigate the progression of astrocyte reactivity across the AD continuum, including healthy …

jp (code pays fourni par la source)

Impact of simulation settings, time-activity curve integration range, and imaging time points on full Monte Carlo-based 177Lu-DOTATATE dosimetry

Shu Kimura, Noriaki Miyaji, Kenta Miwa, Tensho Yamao et autres

jp (code pays fourni par la source)

Quantitative validation of data-driven motion correction for brain PET using phantom with motion generator system

Yuto Kamitaka, Muneyuki Sakata, Keiichi Oda, Akie Katsuki et autres

BACKGROUND: Head motion during brain positron emission tomography (PET) degrades image quality and quantitative accuracy. Therefore, a data-driven motion correction (MC) method utilizing ultrafast list-mode reconstruction technology has been proposed and shown to considerably improve image quality. However, reproducing accurate actual motions …

jp, es (code pays fourni par la source)

Inter-institutional variability in kidney dosimetry during 177Lu-DOTATATE therapy in Japan

Noriaki Miyaji, Kenta Miwa, Kosuke Yamashita, Yasuo Yamashita et autres

jp (code pays fourni par la source)

Potential of Hybrid PSF Correction to Suppress Gibbs Artifacts in PET Imaging

Tsubasa Hirakawa, Kei Wagatsuma, Muneyuki Sakata, Yuto Kamitaka et autres

Point-spread-function (PSF) correction is used to compensate for the degradation of spatial resolution in positron emission tomography (PET) imaging. PSF correction improves image contrast and reduces image noise. However, it also causes Gibbs artifacts, which appear as signal overshoot along object edges, …

jp, es (code pays fourni par la source)

Innovations in clinical PET image reconstruction: advances in Bayesian penalized likelihood algorithm and deep learning

Kenta Miwa, Tensho Yamao, Fumio Hashimoto, Noriaki Miyaji et autres

Abstract Recent advances in PET image reconstruction have focused on achieving high image quality and quantitative accuracy. Bayesian penalized likelihood (BPL) algorithms, such as Q.Clear and HYPER Iterative that have been integrated into commercial PET systems offer robust image noise suppression and …

jp, us (code pays fourni par la source)

Contrast of Early Phase Amyloid PET

Masashi Kameyama, Muneyuki Sakata, Kenji Ishibashi, Tetsuro Tago et autres

Abstract Background The method of obtaining pseudo‐cerebral blood flow images from the initial minutes of amyloid PET scans has been proposed. This technique proves to be highly valuable as it not only indicates the presence of amyloid accumulation but also reveals sites …

jp (code pays fourni par la source)

Contrast of Early Phase Amyloid PET

Masashi Kameyama, Muneyuki Sakata, Kenji Ishibashi, Tetsuro Tago et autres

Abstract Background The method of obtaining pseudo‐cerebral blood flow images from the initial minutes of amyloid PET scans has been proposed. This technique proves to be highly valuable as it not only indicates the presence of amyloid accumulation but also reveals sites …

jp (code pays fourni par la source)